Visceral Leishmaniasis and HIV Coinfection in East Africa

Hdl Handle:
http://hdl.handle.net/10144/322463
Title:
Visceral Leishmaniasis and HIV Coinfection in East Africa
Authors:
Diro, Ermias; Lynen, Lutgarde; Ritmeijer, Koert; Boelaert, Marleen; Hailu, Asrat; van Griensven, Johan
Journal:
PLoS Neglected Tropical Diseases
Abstract:
Visceral Leishmaniasis (VL) is an important protozoan opportunistic disease in HIV patients in endemic areas. East Africa is second to the Indian subcontinent in the global VL caseload and first in VL-HIV coinfection rate. Because of the alteration in the disease course, the diagnostic challenges, and the poor treatment responses, VL with HIV coinfection has become a very serious challenge in East Africa today. Field experience with the use of liposomal amphotericin B in combination with miltefosine, followed by secondary prophylaxis and antiretroviral drugs, looks promising. However, this needs to be confirmed through clinical trials. Better diagnostic and follow-up methods for relapse and prediction of relapse should also be looked for. Basic research to understand the immunological interaction of the two infections may ultimately help to improve the management of the coinfection.
Issue Date:
26-Jun-2014
URI:
http://hdl.handle.net/10144/322463
DOI:
10.1371/journal.pntd.0002869
PubMed ID:
24968313
Language:
en
ISSN:
1935-2735
Appears in Collections:
Leishmaniasis/Kala Azar

Full metadata record

DC FieldValue Language
dc.contributor.authorDiro, Ermiasen_GB
dc.contributor.authorLynen, Lutgardeen_GB
dc.contributor.authorRitmeijer, Koerten_GB
dc.contributor.authorBoelaert, Marleenen_GB
dc.contributor.authorHailu, Asraten_GB
dc.contributor.authorvan Griensven, Johanen_GB
dc.date.accessioned2014-07-04T20:10:04Z-
dc.date.available2014-07-04T20:10:04Z-
dc.date.issued2014-06-26-
dc.identifier.citationVisceral Leishmaniasis and HIV Coinfection in East Africa. 2014, 8 (6):e2869 PLoS Negl Trop Disen_GB
dc.identifier.issn1935-2735-
dc.identifier.pmid24968313-
dc.identifier.doi10.1371/journal.pntd.0002869-
dc.identifier.urihttp://hdl.handle.net/10144/322463-
dc.description.abstractVisceral Leishmaniasis (VL) is an important protozoan opportunistic disease in HIV patients in endemic areas. East Africa is second to the Indian subcontinent in the global VL caseload and first in VL-HIV coinfection rate. Because of the alteration in the disease course, the diagnostic challenges, and the poor treatment responses, VL with HIV coinfection has become a very serious challenge in East Africa today. Field experience with the use of liposomal amphotericin B in combination with miltefosine, followed by secondary prophylaxis and antiretroviral drugs, looks promising. However, this needs to be confirmed through clinical trials. Better diagnostic and follow-up methods for relapse and prediction of relapse should also be looked for. Basic research to understand the immunological interaction of the two infections may ultimately help to improve the management of the coinfection.en_GB
dc.languageENG-
dc.language.isoenen
dc.rightsArchived with thanks to PLoS Neglected Tropical Diseasesen_GB
dc.subjectLeishmaniasisen_GB
dc.subjectHIV/AIDSen_GB
dc.titleVisceral Leishmaniasis and HIV Coinfection in East Africaen
dc.identifier.journalPLoS Neglected Tropical Diseasesen_GB

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