False-positive Xpert(®) MTB/RIF assays in previously treated patients: need for caution in interpreting results.

Hdl Handle:
http://hdl.handle.net/10144/322672
Title:
False-positive Xpert(®) MTB/RIF assays in previously treated patients: need for caution in interpreting results.
Authors:
Boyles, T H; Hughes, J; Cox, V; Burton, R; Meintjes, G; Mendelson, M
Journal:
International Journal of Tuberculosis and Lung Disease
Abstract:
Xpert(®) MTB/RIF is the initial diagnostic test of choice for tuberculosis (TB). It is not known if false-positive results are more common in previously treated patients. We report four patients with successful treatment for TB up to 5 years previously who presented with respiratory tract infection and were Xpert-positive, but had negative TB cultures and clinical improvement without anti-tuberculosis treatment. We hypothesise that the Xpert results were false-positive due to the presence of dead Mycobacterium tuberculosis bacilli in lungs and sputum. Further work is required to determine the specificity of Xpert in previously treated patients.
Issue Date:
Jul-2014
URI:
http://hdl.handle.net/10144/322672
DOI:
10.5588/ijtld.13.0853
PubMed ID:
24902569
Language:
en
ISSN:
1815-7920
Appears in Collections:
TB

Full metadata record

DC FieldValue Language
dc.contributor.authorBoyles, T Hen_GB
dc.contributor.authorHughes, Jen_GB
dc.contributor.authorCox, Ven_GB
dc.contributor.authorBurton, Ren_GB
dc.contributor.authorMeintjes, Gen_GB
dc.contributor.authorMendelson, Men_GB
dc.date.accessioned2014-07-08T15:47:12Z-
dc.date.available2014-07-08T15:47:12Z-
dc.date.issued2014-07-
dc.identifier.citationFalse-positive Xpert(®) MTB/RIF assays in previously treated patients: need for caution in interpreting results. 2014, 18 (7):876-8 Int. J. Tuberc. Lung Dis.en_GB
dc.identifier.issn1815-7920-
dc.identifier.pmid24902569-
dc.identifier.doi10.5588/ijtld.13.0853-
dc.identifier.urihttp://hdl.handle.net/10144/322672-
dc.description.abstractXpert(®) MTB/RIF is the initial diagnostic test of choice for tuberculosis (TB). It is not known if false-positive results are more common in previously treated patients. We report four patients with successful treatment for TB up to 5 years previously who presented with respiratory tract infection and were Xpert-positive, but had negative TB cultures and clinical improvement without anti-tuberculosis treatment. We hypothesise that the Xpert results were false-positive due to the presence of dead Mycobacterium tuberculosis bacilli in lungs and sputum. Further work is required to determine the specificity of Xpert in previously treated patients.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to The International Journal of Tuberculosis and Lung Disease : the official journal of the International Union against Tuberculosis and Lung Diseaseen_GB
dc.titleFalse-positive Xpert(®) MTB/RIF assays in previously treated patients: need for caution in interpreting results.en
dc.identifier.journalInternational Journal of Tuberculosis and Lung Diseaseen_GB

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