Analysis of a novel field dilution method for testing samples that exceed the analytic range of point-of-care blood lead analyzers.

Hdl Handle:
http://hdl.handle.net/10144/323778
Title:
Analysis of a novel field dilution method for testing samples that exceed the analytic range of point-of-care blood lead analyzers.
Authors:
Neri, Antonio James; Roy, Joannie; Jarrett, Jeffery; Pan, Yi; Dooyema, Carrie; Caldwell, Kathleen; Umar-Tsafe, Nasir Tsafe; Olubiyo, Ruth; Brown, Mary Jean
Journal:
International Journal of Environmental Health Research
Abstract:
Investigators developed and evaluated a dilution method for the LeadCare II analyzer (LCII) for blood lead levels >65 μg/dL, the analyzer's maximum reporting value. Venous blood samples from lead-poisoned children were initially analyzed in the field using the dilution method. Split samples were analyzed at the US Centers for Disease Control and Prevention (CDC) laboratory using both the dilution method and inductively coupled plasma-mass spectrometry (ICP-MS). The concordance correlation coefficient of CDC LCII vs. ICP-MS values (N = 211) was 0.976 (95 % confidence interval (CI) 0.970-0.981); of Field LCII vs. ICP-MS (N = 68) was 0.910 (95% CI 0.861-0.942), and CDC LCII vs. Field LCII (N = 53) was 0.721 (95% CI 0.565-0.827). Sixty percent of CDC and 54% of Field LCII values were within ±10% of the ICP-MS value. Results from the dilution method approximated ICP-MS values and were useful for field-based decision-making. Specific recommendations for additional evaluation are provided.
Publisher:
Taylor and Francis Group
Issue Date:
Oct-2013
URI:
http://hdl.handle.net/10144/323778
DOI:
10.1080/09603123.2013.857390
PubMed ID:
24266724
Additional Links:
http://www.tandfonline.com/doi/full/10.1080/09603123.2013.857390
Language:
en
Description:
To access this article, click on "Additional Links".
ISSN:
1369-1619
Appears in Collections:
Laboratory

Full metadata record

DC FieldValue Language
dc.contributor.authorNeri, Antonio Jamesen_GB
dc.contributor.authorRoy, Joannieen_GB
dc.contributor.authorJarrett, Jefferyen_GB
dc.contributor.authorPan, Yien_GB
dc.contributor.authorDooyema, Carrieen_GB
dc.contributor.authorCaldwell, Kathleenen_GB
dc.contributor.authorUmar-Tsafe, Nasir Tsafeen_GB
dc.contributor.authorOlubiyo, Ruthen_GB
dc.contributor.authorBrown, Mary Jeanen_GB
dc.date.accessioned2014-07-24T21:43:45Z-
dc.date.available2014-07-24T21:43:45Z-
dc.date.issued2013-10-
dc.identifier.citationAnalysis of a novel field dilution method for testing samples that exceed the analytic range of point-of-care blood lead analyzers. 2014, 24 (5):418-28 Int J Environ Health Resen_GB
dc.identifier.issn1369-1619-
dc.identifier.pmid24266724-
dc.identifier.doi10.1080/09603123.2013.857390-
dc.identifier.urihttp://hdl.handle.net/10144/323778-
dc.descriptionTo access this article, click on "Additional Links".en_GB
dc.description.abstractInvestigators developed and evaluated a dilution method for the LeadCare II analyzer (LCII) for blood lead levels >65 μg/dL, the analyzer's maximum reporting value. Venous blood samples from lead-poisoned children were initially analyzed in the field using the dilution method. Split samples were analyzed at the US Centers for Disease Control and Prevention (CDC) laboratory using both the dilution method and inductively coupled plasma-mass spectrometry (ICP-MS). The concordance correlation coefficient of CDC LCII vs. ICP-MS values (N = 211) was 0.976 (95 % confidence interval (CI) 0.970-0.981); of Field LCII vs. ICP-MS (N = 68) was 0.910 (95% CI 0.861-0.942), and CDC LCII vs. Field LCII (N = 53) was 0.721 (95% CI 0.565-0.827). Sixty percent of CDC and 54% of Field LCII values were within ±10% of the ICP-MS value. Results from the dilution method approximated ICP-MS values and were useful for field-based decision-making. Specific recommendations for additional evaluation are provided.en_GB
dc.language.isoenen
dc.publisherTaylor and Francis Groupen_GB
dc.relation.urlhttp://www.tandfonline.com/doi/full/10.1080/09603123.2013.857390en_GB
dc.rightsArchived with thanks to the Taylor and Francis Group and International journal of environmental health researchen_GB
dc.titleAnalysis of a novel field dilution method for testing samples that exceed the analytic range of point-of-care blood lead analyzers.en
dc.identifier.journalInternational Journal of Environmental Health Researchen_GB

Related articles on PubMed

All Items in MSF are protected by copyright, with all rights reserved, unless otherwise indicated.