The kynurenine pathway of tryptophan catabolism, CD4+ T-cell recovery, and mortality among HIV-infected Ugandans initiating antiretroviral therapy.

Hdl Handle:
http://hdl.handle.net/10144/331942
Title:
The kynurenine pathway of tryptophan catabolism, CD4+ T-cell recovery, and mortality among HIV-infected Ugandans initiating antiretroviral therapy.
Authors:
Byakwaga, Helen; Boum, Yap; Huang, Yong; Muzoora, Conrad; Kembabazi, Annet; Weiser, Sheri D; Bennett, John; Cao, Huyen; Haberer, Jessica E; Deeks, Steven G; Bangsberg, David R; McCune, Joseph M; Martin, Jeffrey N; Hunt, Peter W
Journal:
The Journal of Infectious Diseases
Abstract:
Human immunodeficiency virus (HIV) infection-induced indoleamine 2,3-dioxygenase-1 (IDO) expression in activated monocytes and dendritic cells catabolizes tryptophan to kynurenine and other downstream catabolites that inhibit T-cell proliferation and interleukin 17 (IL-17) production. The prognostic significance of this pathway in treated HIV disease is unknown.
Publisher:
Oxford University Press
Issue Date:
1-Aug-2014
URI:
http://hdl.handle.net/10144/331942
DOI:
10.1093/infdis/jiu115
PubMed ID:
24585899
Type:
Article
Language:
en
ISSN:
1537-6613
Appears in Collections:
HIV/AIDS

Full metadata record

DC FieldValue Language
dc.contributor.authorByakwaga, Helenen_GB
dc.contributor.authorBoum, Yapen_GB
dc.contributor.authorHuang, Yongen_GB
dc.contributor.authorMuzoora, Conraden_GB
dc.contributor.authorKembabazi, Anneten_GB
dc.contributor.authorWeiser, Sheri Den_GB
dc.contributor.authorBennett, Johnen_GB
dc.contributor.authorCao, Huyenen_GB
dc.contributor.authorHaberer, Jessica Een_GB
dc.contributor.authorDeeks, Steven Gen_GB
dc.contributor.authorBangsberg, David Ren_GB
dc.contributor.authorMcCune, Joseph Men_GB
dc.contributor.authorMartin, Jeffrey Nen_GB
dc.contributor.authorHunt, Peter Wen_GB
dc.date.accessioned2014-09-29T14:05:49Z-
dc.date.available2014-09-29T14:05:49Z-
dc.date.issued2014-08-01-
dc.identifier.citationThe kynurenine pathway of tryptophan catabolism, CD4+ T-cell recovery, and mortality among HIV-infected Ugandans initiating antiretroviral therapy. 2014, 210 (3):383-91 J. Infect. Dis.en_GB
dc.identifier.issn1537-6613-
dc.identifier.pmid24585899-
dc.identifier.doi10.1093/infdis/jiu115-
dc.identifier.urihttp://hdl.handle.net/10144/331942-
dc.description.abstractHuman immunodeficiency virus (HIV) infection-induced indoleamine 2,3-dioxygenase-1 (IDO) expression in activated monocytes and dendritic cells catabolizes tryptophan to kynurenine and other downstream catabolites that inhibit T-cell proliferation and interleukin 17 (IL-17) production. The prognostic significance of this pathway in treated HIV disease is unknown.en_GB
dc.language.isoenen
dc.publisherOxford University Pressen_GB
dc.rightsPublished by Infectious Diseases Society of America Archived on this site with permission and copyright 2014 by the Infectious Diseases Society of America, [url] and Oxford University Pressen_GB
dc.subjectHIVen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAnti-HIV Agentsen_GB
dc.subject.meshCD4 Lymphocyte Counten_GB
dc.subject.meshCD4-Positive T-Lymphocytesen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHIV Infectionsen_GB
dc.subject.meshHumansen_GB
dc.subject.meshKynurenineen_GB
dc.subject.meshMaleen_GB
dc.subject.meshTryptophanen_GB
dc.subject.meshUgandaen_GB
dc.titleThe kynurenine pathway of tryptophan catabolism, CD4+ T-cell recovery, and mortality among HIV-infected Ugandans initiating antiretroviral therapy.en
dc.typeArticleen
dc.identifier.journalThe Journal of Infectious Diseasesen_GB

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