Description of 3,180 Courses of Chelation with Dimercaptosuccinic Acid in Children ≤5 y with Severe Lead Poisoning in Zamfara, Northern Nigeria: A Retrospective Analysis of Programme Data

Hdl Handle:
http://hdl.handle.net/10144/332891
Title:
Description of 3,180 Courses of Chelation with Dimercaptosuccinic Acid in Children ≤5 y with Severe Lead Poisoning in Zamfara, Northern Nigeria: A Retrospective Analysis of Programme Data
Authors:
Thurtle, Natalie; Greig, Jane; Cooney, Lauren; Amitai, Yona; Ariti, Cono; Brown, Mary Jean; Kosnett, Michael J; Moussally, Krystel; Sani-Gwarzo, Nasir; Akpan, Henry; Shanks, Leslie; Dargan, Paul I
Journal:
PLoS Medicine
Abstract:
In 2010, Médecins Sans Frontières (MSF) discovered extensive lead poisoning impacting several thousand children in rural northern Nigeria. An estimated 400 fatalities had occurred over 3 mo. The US Centers for Disease Control and Prevention (CDC) confirmed widespread contamination from lead-rich ore being processed for gold, and environmental management was begun. MSF commenced a medical management programme that included treatment with the oral chelating agent 2,3-dimercaptosuccinic acid (DMSA, succimer). Here we describe and evaluate the changes in venous blood lead level (VBLL) associated with DMSA treatment in the largest cohort of children ≤5 y of age with severe paediatric lead intoxication reported to date to our knowledge.
Publisher:
Public Library of Science
Issue Date:
7-Oct-2014
URI:
http://hdl.handle.net/10144/332891
DOI:
10.1371/journal.pmed.1001739
PubMed ID:
25291378
Language:
en
ISSN:
1549-1676
Appears in Collections:
Paediatrics

Full metadata record

DC FieldValue Language
dc.contributor.authorThurtle, Natalieen_GB
dc.contributor.authorGreig, Janeen_GB
dc.contributor.authorCooney, Laurenen_GB
dc.contributor.authorAmitai, Yonaen_GB
dc.contributor.authorAriti, Conoen_GB
dc.contributor.authorBrown, Mary Jeanen_GB
dc.contributor.authorKosnett, Michael Jen_GB
dc.contributor.authorMoussally, Krystelen_GB
dc.contributor.authorSani-Gwarzo, Nasiren_GB
dc.contributor.authorAkpan, Henryen_GB
dc.contributor.authorShanks, Leslieen_GB
dc.contributor.authorDargan, Paul Ien_GB
dc.date.accessioned2014-10-17T15:41:12Z-
dc.date.available2014-10-17T15:41:12Z-
dc.date.issued2014-10-07-
dc.identifier.citationDescription of 3,180 Courses of Chelation with Dimercaptosuccinic Acid in Children ≤5 y with Severe Lead Poisoning in Zamfara, Northern Nigeria: A Retrospective Analysis of Programme Data. 2014, 11 (10):e1001739 PLoS Med.en_GB
dc.identifier.issn1549-1676-
dc.identifier.pmid25291378-
dc.identifier.doi10.1371/journal.pmed.1001739-
dc.identifier.urihttp://hdl.handle.net/10144/332891-
dc.description.abstractIn 2010, Médecins Sans Frontières (MSF) discovered extensive lead poisoning impacting several thousand children in rural northern Nigeria. An estimated 400 fatalities had occurred over 3 mo. The US Centers for Disease Control and Prevention (CDC) confirmed widespread contamination from lead-rich ore being processed for gold, and environmental management was begun. MSF commenced a medical management programme that included treatment with the oral chelating agent 2,3-dimercaptosuccinic acid (DMSA, succimer). Here we describe and evaluate the changes in venous blood lead level (VBLL) associated with DMSA treatment in the largest cohort of children ≤5 y of age with severe paediatric lead intoxication reported to date to our knowledge.en_GB
dc.language.isoenen
dc.publisherPublic Library of Scienceen_GB
dc.rightsPublished by Public Library of Science, [url]http://medicine.plosjournals.org/[/url] Archived on this site by Open Access permissionen_GB
dc.titleDescription of 3,180 Courses of Chelation with Dimercaptosuccinic Acid in Children ≤5 y with Severe Lead Poisoning in Zamfara, Northern Nigeria: A Retrospective Analysis of Programme Dataen
dc.identifier.journalPLoS Medicineen_GB

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