Male Gender is independently associated with pulmonary tuberculosis among sputum and non-sputum producers people with presumptive tuberculosis in Southwestern Uganda

Hdl Handle:
http://hdl.handle.net/10144/337711
Title:
Male Gender is independently associated with pulmonary tuberculosis among sputum and non-sputum producers people with presumptive tuberculosis in Southwestern Uganda
Authors:
Boum, Y; Atwine, D; Orikiriza, P; Assimwe, J; Page, A-L; Mwanga-Amumpaire, J; Bonnet, M
Journal:
BMC Infectious Diseases
Abstract:
BackgroundLittle is known about the association between gender and risk of TB infection. We sought to assess the impact of gender on TB prevalence among people with presumptive tuberculosis at a regional referral hospital in a high TB and HIV prevalence setting.MethodsWe analyzed data from two diagnostic TB studies conducted in rural, southwestern Uganda. People with presumptive tuberculosis were evaluated by chest X-ray, fluorescence microscopy, TB culture, and HIV testing. Our primary outcome of interest was TB infection, as defined by a positive TB culture. Our primary explanatory variable of interest was gender. We fit univariable and multivariable logistic regression models to investigate associations between TB infection and gender, before and after adjusting or possible confounding factors, including ability to produce sputum, age and residence.ResultsBetween April 2010 and September 2012, 863 people with presumptive tuberculosis (PWPTB) were enrolled in the two studies at Mbarara Regional Referral Hospital (MRRH) in Uganda. Among them 664 (76.9%) were able to produce sputum. X-ray was suggestive of TB for 258 (66.5%) of males and 175 (44.8%) of female (p¿<¿0.001). using microscopy 84 (20%) of males and 48 (10.9%) of females were diagnosed with TB (p¿<¿0.001) while 122 (30.3%) of males and 76 (18.4%) of females were diagnosed with TB (p¿<¿0.001) using TB culture.In multivariable logistic regression models, the odds of having TB was higher in males than females (AOR 2.2 (1.56-3.18 95%CI°, P¿<¿0.001), after adjustment for age, HIV status, ability to produce sputum, and residence.ConclusionIn Southwestern Uganda, TB prevalence is higher among male than female people with presumptive TB. The increased risk of TB among males is independent of other TB risk factors. These findings emphasize the need for gender-focused interventions aimed at reducing TB transmission.
Publisher:
BioMed Central
Issue Date:
10-Dec-2014
URI:
http://hdl.handle.net/10144/337711
DOI:
10.1186/s12879-014-0638-5
PubMed ID:
25492725
Language:
en
ISSN:
1471-2334
Appears in Collections:
TB

Full metadata record

DC FieldValue Language
dc.contributor.authorBoum, Yen_GB
dc.contributor.authorAtwine, Den_GB
dc.contributor.authorOrikiriza, Pen_GB
dc.contributor.authorAssimwe, Jen_GB
dc.contributor.authorPage, A-Len_GB
dc.contributor.authorMwanga-Amumpaire, Jen_GB
dc.contributor.authorBonnet, Men_GB
dc.date.accessioned2014-12-30T23:51:09Z-
dc.date.available2014-12-30T23:51:09Z-
dc.date.issued2014-12-10-
dc.identifier.citationMale Gender is independently associated with pulmonary tuberculosis among sputum and non-sputum producers people with presumptive tuberculosis in Southwestern Uganda. 2014, 14 (1):638 BMC Infect. Dis.en_GB
dc.identifier.issn1471-2334-
dc.identifier.pmid25492725-
dc.identifier.doi10.1186/s12879-014-0638-5-
dc.identifier.urihttp://hdl.handle.net/10144/337711-
dc.description.abstractBackgroundLittle is known about the association between gender and risk of TB infection. We sought to assess the impact of gender on TB prevalence among people with presumptive tuberculosis at a regional referral hospital in a high TB and HIV prevalence setting.MethodsWe analyzed data from two diagnostic TB studies conducted in rural, southwestern Uganda. People with presumptive tuberculosis were evaluated by chest X-ray, fluorescence microscopy, TB culture, and HIV testing. Our primary outcome of interest was TB infection, as defined by a positive TB culture. Our primary explanatory variable of interest was gender. We fit univariable and multivariable logistic regression models to investigate associations between TB infection and gender, before and after adjusting or possible confounding factors, including ability to produce sputum, age and residence.ResultsBetween April 2010 and September 2012, 863 people with presumptive tuberculosis (PWPTB) were enrolled in the two studies at Mbarara Regional Referral Hospital (MRRH) in Uganda. Among them 664 (76.9%) were able to produce sputum. X-ray was suggestive of TB for 258 (66.5%) of males and 175 (44.8%) of female (p¿<¿0.001). using microscopy 84 (20%) of males and 48 (10.9%) of females were diagnosed with TB (p¿<¿0.001) while 122 (30.3%) of males and 76 (18.4%) of females were diagnosed with TB (p¿<¿0.001) using TB culture.In multivariable logistic regression models, the odds of having TB was higher in males than females (AOR 2.2 (1.56-3.18 95%CI°, P¿<¿0.001), after adjustment for age, HIV status, ability to produce sputum, and residence.ConclusionIn Southwestern Uganda, TB prevalence is higher among male than female people with presumptive TB. The increased risk of TB among males is independent of other TB risk factors. These findings emphasize the need for gender-focused interventions aimed at reducing TB transmission.en_GB
dc.languageENG-
dc.language.isoenen
dc.publisherBioMed Centralen_GB
dc.rightsArchived with thanks to BMC Infectious Diseasesen_GB
dc.titleMale Gender is independently associated with pulmonary tuberculosis among sputum and non-sputum producers people with presumptive tuberculosis in Southwestern Ugandaen
dc.identifier.journalBMC Infectious Diseasesen_GB

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