Public-health and individual approaches to antiretroviral therapy: township South Africa and Switzerland compared.

Hdl Handle:
http://hdl.handle.net/10144/38313
Title:
Public-health and individual approaches to antiretroviral therapy: township South Africa and Switzerland compared.
Authors:
Keiser, O; Orrell, C; Egger, M; Wood, R; Brinkhof, M W G; Furrer, H; Van Cutsem, G; Ledergerber, B; Boulle, A
Journal:
PLoS Medicine
Abstract:
BACKGROUND: The provision of highly active antiretroviral therapy (HAART) in resource-limited settings follows a public health approach, which is characterised by a limited number of regimens and the standardisation of clinical and laboratory monitoring. In industrialized countries doctors prescribe from the full range of available antiretroviral drugs, supported by resistance testing and frequent laboratory monitoring. We compared virologic response, changes to first-line regimens, and mortality in HIV-infected patients starting HAART in South Africa and Switzerland. METHODS AND FINDINGS: We analysed data from the Swiss HIV Cohort Study and two HAART programmes in townships of Cape Town, South Africa. We included treatment-naïve patients aged 16 y or older who had started treatment with at least three drugs since 2001, and excluded intravenous drug users. Data from a total of 2,348 patients from South Africa and 1,016 patients from the Swiss HIV Cohort Study were analysed. Median baseline CD4+ T cell counts were 80 cells/mul in South Africa and 204 cells/mul in Switzerland. In South Africa, patients started with one of four first-line regimens, which was subsequently changed in 514 patients (22%). In Switzerland, 36 first-line regimens were used initially, and these were changed in 539 patients (53%). In most patients HIV-1 RNA was suppressed to 500 copies/ml or less within one year: 96% (95% confidence interval [CI] 95%-97%) in South Africa and 96% (94%-97%) in Switzerland, and 26% (22%-29%) and 27% (24%-31%), respectively, developed viral rebound within two years. Mortality was higher in South Africa than in Switzerland during the first months of HAART: adjusted hazard ratios were 5.90 (95% CI 1.81-19.2) during months 1-3 and 1.77 (0.90-3.50) during months 4-24. CONCLUSIONS: Compared to the highly individualised approach in Switzerland, programmatic HAART in South Africa resulted in similar virologic outcomes, with relatively few changes to initial regimens. Further innovation and resources are required in South Africa to both achieve more timely access to HAART and improve the prognosis of patients who start HAART with advanced disease.
Affiliation:
Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland.
Publisher:
PLoS
Issue Date:
8-Jul-2008
URI:
http://hdl.handle.net/10144/38313
DOI:
10.1371/journal.pmed.0050148
PubMed ID:
18613745
Language:
en
ISSN:
1549-1676
Appears in Collections:
HIV/AIDS

Full metadata record

DC FieldValue Language
dc.contributor.authorKeiser, O-
dc.contributor.authorOrrell, C-
dc.contributor.authorEgger, M-
dc.contributor.authorWood, R-
dc.contributor.authorBrinkhof, M W G-
dc.contributor.authorFurrer, H-
dc.contributor.authorVan Cutsem, G-
dc.contributor.authorLedergerber, B-
dc.contributor.authorBoulle, A-
dc.date.accessioned2008-09-30T07:34:27Z-
dc.date.available2008-09-30T07:34:27Z-
dc.date.issued2008-07-08-
dc.identifier.citationPublic-health and individual approaches to antiretroviral therapy: township South Africa and Switzerland compared. 2008, 5 (7):e148 PLoS Med.en
dc.identifier.issn1549-1676-
dc.identifier.pmid18613745-
dc.identifier.doi10.1371/journal.pmed.0050148-
dc.identifier.urihttp://hdl.handle.net/10144/38313-
dc.description.abstractBACKGROUND: The provision of highly active antiretroviral therapy (HAART) in resource-limited settings follows a public health approach, which is characterised by a limited number of regimens and the standardisation of clinical and laboratory monitoring. In industrialized countries doctors prescribe from the full range of available antiretroviral drugs, supported by resistance testing and frequent laboratory monitoring. We compared virologic response, changes to first-line regimens, and mortality in HIV-infected patients starting HAART in South Africa and Switzerland. METHODS AND FINDINGS: We analysed data from the Swiss HIV Cohort Study and two HAART programmes in townships of Cape Town, South Africa. We included treatment-naïve patients aged 16 y or older who had started treatment with at least three drugs since 2001, and excluded intravenous drug users. Data from a total of 2,348 patients from South Africa and 1,016 patients from the Swiss HIV Cohort Study were analysed. Median baseline CD4+ T cell counts were 80 cells/mul in South Africa and 204 cells/mul in Switzerland. In South Africa, patients started with one of four first-line regimens, which was subsequently changed in 514 patients (22%). In Switzerland, 36 first-line regimens were used initially, and these were changed in 539 patients (53%). In most patients HIV-1 RNA was suppressed to 500 copies/ml or less within one year: 96% (95% confidence interval [CI] 95%-97%) in South Africa and 96% (94%-97%) in Switzerland, and 26% (22%-29%) and 27% (24%-31%), respectively, developed viral rebound within two years. Mortality was higher in South Africa than in Switzerland during the first months of HAART: adjusted hazard ratios were 5.90 (95% CI 1.81-19.2) during months 1-3 and 1.77 (0.90-3.50) during months 4-24. CONCLUSIONS: Compared to the highly individualised approach in Switzerland, programmatic HAART in South Africa resulted in similar virologic outcomes, with relatively few changes to initial regimens. Further innovation and resources are required in South Africa to both achieve more timely access to HAART and improve the prognosis of patients who start HAART with advanced disease.en
dc.language.isoenen
dc.publisherPLoSen
dc.rightsPublished by Public Library of Science, [url]http://medicine.plosjournals.org/[/url] Archived on this site by Open Access permissionen
dc.titlePublic-health and individual approaches to antiretroviral therapy: township South Africa and Switzerland compared.en
dc.contributor.departmentInstitute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland.en
dc.identifier.journalPLoS Medicineen

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