Rapid culture-based methods for drug-resistance detection in Mycobacterium tuberculosis.

Hdl Handle:
http://hdl.handle.net/10144/39615
Title:
Rapid culture-based methods for drug-resistance detection in Mycobacterium tuberculosis.
Authors:
Palomino, J C; Martin, A; Von Groll, A; Portaels, F
Journal:
Journal of Microbiological Methods
Abstract:
Tuberculosis still represents a major public health problem, especially in low-resource countries where the burden of the disease is more important. Multidrug-resistant and extensively drug drug-resistant tuberculosis constitute serious problems for the efficient control of the disease stressing the need to investigate resistance to first- and second-line drugs. Conventional methods for detecting drug-resistance in Mycobacterium tuberculosis are slow and cumbersome. The most commonly used proportion method on Löwenstein-Jensen medium or Middlebrook agar requires a minimum of 3-4 weeks to produce results. Several new approaches have been proposed in the last years for the rapid and timely detection of drug-resistance in tuberculosis. This review will address phenotypic culture-based methods for rapid drug susceptibility testing in M. tuberculosis.
Affiliation:
Mycobacteriology Unit, Institute of Tropical Medicine, Nationalestraat 155, 2000 Antwerp, Belgium.
Publisher:
Elsevier
Issue Date:
Oct-2008
URI:
http://hdl.handle.net/10144/39615
DOI:
10.1016/j.mimet.2008.06.015
PubMed ID:
18627779
Additional Links:
http://www.sciencedirect.com/science/journal/01677012.
Language:
en
ISSN:
0167-7012
Appears in Collections:
TB

Full metadata record

DC FieldValue Language
dc.contributor.authorPalomino, J C-
dc.contributor.authorMartin, A-
dc.contributor.authorVon Groll, A-
dc.contributor.authorPortaels, F-
dc.date.accessioned2008-10-24T12:43:14Z-
dc.date.available2008-10-24T12:43:14Z-
dc.date.issued2008-10-
dc.identifier.citationRapid culture-based methods for drug-resistance detection in Mycobacterium tuberculosis. 2008, 75 (2):161-6 J. Microbiol. Methodsen
dc.identifier.issn0167-7012-
dc.identifier.pmid18627779-
dc.identifier.doi10.1016/j.mimet.2008.06.015-
dc.identifier.urihttp://hdl.handle.net/10144/39615-
dc.description.abstractTuberculosis still represents a major public health problem, especially in low-resource countries where the burden of the disease is more important. Multidrug-resistant and extensively drug drug-resistant tuberculosis constitute serious problems for the efficient control of the disease stressing the need to investigate resistance to first- and second-line drugs. Conventional methods for detecting drug-resistance in Mycobacterium tuberculosis are slow and cumbersome. The most commonly used proportion method on Löwenstein-Jensen medium or Middlebrook agar requires a minimum of 3-4 weeks to produce results. Several new approaches have been proposed in the last years for the rapid and timely detection of drug-resistance in tuberculosis. This review will address phenotypic culture-based methods for rapid drug susceptibility testing in M. tuberculosis.en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttp://www.sciencedirect.com/science/journal/01677012.en
dc.rightsArchived with kind thanks to Elsevier, copyright 2008.en
dc.titleRapid culture-based methods for drug-resistance detection in Mycobacterium tuberculosis.en
dc.contributor.departmentMycobacteriology Unit, Institute of Tropical Medicine, Nationalestraat 155, 2000 Antwerp, Belgium.en
dc.identifier.journalJournal of Microbiological Methodsen

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