The emerging crisis of drug-resistant tuberculosis in South Africa: lessons from New York City.

Hdl Handle:
http://hdl.handle.net/10144/41794
Title:
The emerging crisis of drug-resistant tuberculosis in South Africa: lessons from New York City.
Authors:
Murphy, R A
Journal:
Clinical Infectious Diseases
Abstract:
Multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis have emerged as important infections in South Africa among patients infected with human immunodeficiency virus (HIV). In the face of this new epidemic, South Africa must rededicate itself to the task of tuberculosis control and treatment with a rapid, multifaceted approach. Priorities include expansion of second-line treatment capacity, investment in clinical laboratories, a system to ensure supervised treatment for all patients, and enhancement of infection control procedures. In New York City, where drug-resistant tuberculosis emerged 2 decades ago--also in the context of a large HIV-infected population and an underfunded public health infrastructure--similar steps were successful in leading to the rapid decrease in rates of drug resistance among tuberculosis isolates. With refinements based on local resource constraints, urgent measures could potentially arrest the alarming increase in multidrug-resistant and extensively drug-resistant tuberculosis cases in South Africa. Unlike many countries in sub-Saharan Africa, South Africa has the capacity to mount a rapid and large-scale response before drug-resistant tuberculosis envelops a much larger and far poorer region.
Affiliation:
Division of Infectious Diseases, Massachusetts General Hospital and Brigham and Women's Hospital, Boston, Massachusetts, USA. richard.murphy@newyork.msf.org
Issue Date:
1-Jun-2008
URI:
http://hdl.handle.net/10144/41794
DOI:
10.1086/587903
PubMed ID:
18426372
Language:
en
ISSN:
1537-6591
Appears in Collections:
TB

Full metadata record

DC FieldValue Language
dc.contributor.authorMurphy, R A-
dc.date.accessioned2008-12-03T15:19:37Z-
dc.date.available2008-12-03T15:19:37Z-
dc.date.issued2008-06-01-
dc.identifier.citationThe emerging crisis of drug-resistant tuberculosis in South Africa: lessons from New York City. 2008, 46 (11):1729-32 Clin. Infect. Dis.en
dc.identifier.issn1537-6591-
dc.identifier.pmid18426372-
dc.identifier.doi10.1086/587903-
dc.identifier.urihttp://hdl.handle.net/10144/41794-
dc.description.abstractMultidrug-resistant tuberculosis and extensively drug-resistant tuberculosis have emerged as important infections in South Africa among patients infected with human immunodeficiency virus (HIV). In the face of this new epidemic, South Africa must rededicate itself to the task of tuberculosis control and treatment with a rapid, multifaceted approach. Priorities include expansion of second-line treatment capacity, investment in clinical laboratories, a system to ensure supervised treatment for all patients, and enhancement of infection control procedures. In New York City, where drug-resistant tuberculosis emerged 2 decades ago--also in the context of a large HIV-infected population and an underfunded public health infrastructure--similar steps were successful in leading to the rapid decrease in rates of drug resistance among tuberculosis isolates. With refinements based on local resource constraints, urgent measures could potentially arrest the alarming increase in multidrug-resistant and extensively drug-resistant tuberculosis cases in South Africa. Unlike many countries in sub-Saharan Africa, South Africa has the capacity to mount a rapid and large-scale response before drug-resistant tuberculosis envelops a much larger and far poorer region.en
dc.language.isoenen
dc.rightsArchived with thanks to Clinical Infectious Diseases : an official publication of the Infectious Diseases Society of Americaen
dc.subject.meshAIDS-Related Opportunistic Infectionsen
dc.subject.meshAntiretroviral Therapy, Highly Activeen
dc.subject.meshCommunicable Diseases, Emergingen
dc.subject.meshExtensively Drug-Resistant Tuberculosisen
dc.subject.meshHIV Infectionsen
dc.subject.meshHumansen
dc.subject.meshSouth Africaen
dc.subject.meshTuberculosis, Multidrug-Resistanten
dc.titleThe emerging crisis of drug-resistant tuberculosis in South Africa: lessons from New York City.en
dc.contributor.departmentDivision of Infectious Diseases, Massachusetts General Hospital and Brigham and Women's Hospital, Boston, Massachusetts, USA. richard.murphy@newyork.msf.orgen
dc.identifier.journalClinical Infectious Diseasesen

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