The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria.

Hdl Handle:
http://hdl.handle.net/10144/52033
Title:
The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria.
Authors:
Lee, S J; Stepniewska, K; Anstey, N; Ashley, E; Barnes, K; Binh, T Q; D'Alessandro, U; Day, N; de Vries, P J; Dorsey, G; Guthmann, J P; Mayxay, M; Newton, P; Nosten, F; Olliaro, P; Osario, L; Pinoges, L; Price, R; Rowland, M; Smithuis, F; Taylor, R; White, N J
Journal:
Malaria Journal
Abstract:
BACKGROUND: Malaria is a very important cause of anaemia in tropical countries. Anaemia is assessed either by measurement of the haematocrit or the haemoglobin concentration. For comparisons across studies, it is often necessary to derive one measure from the other. METHODS: Data on patients with slide-confirmed uncomplicated falciparum malaria were pooled from 85 antimalarial drug trials conducted in 25 different countries, to assess the haemoglobin/haematocrit relationship at different time points in malaria. Using a linear random effects model, a conversion equation for haematocrit was derived based on 3,254 measurements from various time points (ranging from day 0 to day 63) from 1,810 patients with simultaneous measurements of both parameters. Haemoglobin was also estimated from haematocrit with the commonly used threefold conversion. RESULTS: A good fit was obtained using Haematocrit = 5.62 + 2.60 * Haemoglobin. On average, haematocrit/3 levels were slightly higher than haemoglobin measurements with a mean difference (+/- SD) of -0.69 (+/- 1.3) for children under the age of 5 (n = 1,440 measurements from 449 patients). CONCLUSION: Based on this large data set, an accurate and robust conversion factor both in acute malaria and in convalescence was obtained. The commonly used threefold conversion is also valid.
Affiliation:
Mahidol-Oxford Tropical Medicine Research Unit (MORU), Mahidol University, Faculty of Tropical Medicine, 3rd Floor, 60th Anniversary Chalermprakiat Building, 420/6 Ratchawithi Rd, Ratchathewi District, Bangkok 10400, Thailand. sue@tropmedres.ac
Publisher:
BioMed Central
Issue Date:
Aug-2008
URI:
http://hdl.handle.net/10144/52033
DOI:
10.1186/1475-2875-7-149
PubMed ID:
18673575
Additional Links:
http://www.malariajournal.com
Submitted date:
2008-03-04
Type:
Article
Language:
en
ISSN:
1475-2875
Sponsors:
Epicentre
Appears in Collections:
Malaria

Full metadata record

DC FieldValue Language
dc.contributor.authorLee, S J-
dc.contributor.authorStepniewska, K-
dc.contributor.authorAnstey, N-
dc.contributor.authorAshley, E-
dc.contributor.authorBarnes, K-
dc.contributor.authorBinh, T Q-
dc.contributor.authorD'Alessandro, U-
dc.contributor.authorDay, N-
dc.contributor.authorde Vries, P J-
dc.contributor.authorDorsey, G-
dc.contributor.authorGuthmann, J P-
dc.contributor.authorMayxay, M-
dc.contributor.authorNewton, P-
dc.contributor.authorNosten, F-
dc.contributor.authorOlliaro, P-
dc.contributor.authorOsario, L-
dc.contributor.authorPinoges, L-
dc.contributor.authorPrice, R-
dc.contributor.authorRowland, M-
dc.contributor.authorSmithuis, F-
dc.contributor.authorTaylor, R-
dc.contributor.authorWhite, N J-
dc.date.accessioned2009-03-04T15:19:57Z-
dc.date.available2009-03-04T15:19:57Z-
dc.date.issued2008-08-
dc.date.submitted2008-03-04-
dc.identifier.citationThe relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria. 2008, 7:149 Malar. J.en
dc.identifier.issn1475-2875-
dc.identifier.pmid18673575-
dc.identifier.doi10.1186/1475-2875-7-149-
dc.identifier.urihttp://hdl.handle.net/10144/52033-
dc.description.abstractBACKGROUND: Malaria is a very important cause of anaemia in tropical countries. Anaemia is assessed either by measurement of the haematocrit or the haemoglobin concentration. For comparisons across studies, it is often necessary to derive one measure from the other. METHODS: Data on patients with slide-confirmed uncomplicated falciparum malaria were pooled from 85 antimalarial drug trials conducted in 25 different countries, to assess the haemoglobin/haematocrit relationship at different time points in malaria. Using a linear random effects model, a conversion equation for haematocrit was derived based on 3,254 measurements from various time points (ranging from day 0 to day 63) from 1,810 patients with simultaneous measurements of both parameters. Haemoglobin was also estimated from haematocrit with the commonly used threefold conversion. RESULTS: A good fit was obtained using Haematocrit = 5.62 + 2.60 * Haemoglobin. On average, haematocrit/3 levels were slightly higher than haemoglobin measurements with a mean difference (+/- SD) of -0.69 (+/- 1.3) for children under the age of 5 (n = 1,440 measurements from 449 patients). CONCLUSION: Based on this large data set, an accurate and robust conversion factor both in acute malaria and in convalescence was obtained. The commonly used threefold conversion is also valid.en
dc.description.sponsorshipEpicentreen
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttp://www.malariajournal.comen
dc.rightsPublished by BioMed Central, [url]http://www.malariajournal.com/[/url] Archived on this site by Open Access permissionen
dc.subject.meshAlgorithmsen
dc.subject.meshChild, Preschoolen
dc.subject.meshHematocriten
dc.subject.meshHemoglobinsen
dc.subject.meshHumansen
dc.subject.meshMalaria, Falciparumen
dc.subject.meshPredictive Value of Testsen
dc.titleThe relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria.en
dc.typeArticleen
dc.contributor.departmentMahidol-Oxford Tropical Medicine Research Unit (MORU), Mahidol University, Faculty of Tropical Medicine, 3rd Floor, 60th Anniversary Chalermprakiat Building, 420/6 Ratchawithi Rd, Ratchathewi District, Bangkok 10400, Thailand. sue@tropmedres.acen
dc.identifier.journalMalaria Journalen

Related articles on PubMed

All Items in MSF are protected by copyright, with all rights reserved, unless otherwise indicated.