Challenges in the management of disseminated progressive histoplasmosis in human immunodeficiency virus-infected patients in resource-limited settings

Hdl Handle:
http://hdl.handle.net/10144/560491
Title:
Challenges in the management of disseminated progressive histoplasmosis in human immunodeficiency virus-infected patients in resource-limited settings
Authors:
Murphy, Richard A; Gounder, Lilishia; Manzini, Thandekile C; Ramdial, Pratistadevi K; Castilla, Carmen; Moosa, Mahomed-Yunus S
Journal:
Open Forum Infectious Diseases
Abstract:
The diagnosis of histoplasmosis in patients with human immunodeficiency virus in southern Africa is complicated by the nonspecific presentation of the disease in this patient group and the unavailability of sensitive diagnostics including antigen assays. Treatment options are also limited due to the unavailability of liposomal amphotericin and itraconazole, and the inability to perform therapeutic drug monitoring further confounds management. We present 3 clinical cases to illustrate the limits of diagnosis and management in the southern African context, and we highlight the need for additional diagnostic tools and treatment options in resource-limited settings.
Publisher:
Oxford University Press
Issue Date:
30-Mar-2015
URI:
http://hdl.handle.net/10144/560491
DOI:
10.1093/ofid/ofv025
PubMed ID:
26034774
Language:
en
ISSN:
2328-8957
Appears in Collections:
HIV/AIDS

Full metadata record

DC FieldValue Language
dc.contributor.authorMurphy, Richard Aen_GB
dc.contributor.authorGounder, Lilishiaen_GB
dc.contributor.authorManzini, Thandekile Cen_GB
dc.contributor.authorRamdial, Pratistadevi Ken_GB
dc.contributor.authorCastilla, Carmenen_GB
dc.contributor.authorMoosa, Mahomed-Yunus Sen_GB
dc.date.accessioned2015-07-15T18:18:46Z-
dc.date.available2015-07-15T18:18:46Z-
dc.date.issued2015-03-30-
dc.identifier.citationChallenges in the management of disseminated progressive histoplasmosis in human immunodeficiency virus-infected patients in resource-limited settings. 2015, 2 (1):ofv025 Open Forum Infect Disen_GB
dc.identifier.issn2328-8957-
dc.identifier.pmid26034774-
dc.identifier.doi10.1093/ofid/ofv025-
dc.identifier.urihttp://hdl.handle.net/10144/560491-
dc.description.abstractThe diagnosis of histoplasmosis in patients with human immunodeficiency virus in southern Africa is complicated by the nonspecific presentation of the disease in this patient group and the unavailability of sensitive diagnostics including antigen assays. Treatment options are also limited due to the unavailability of liposomal amphotericin and itraconazole, and the inability to perform therapeutic drug monitoring further confounds management. We present 3 clinical cases to illustrate the limits of diagnosis and management in the southern African context, and we highlight the need for additional diagnostic tools and treatment options in resource-limited settings.en_GB
dc.language.isoenen
dc.publisherOxford University Pressen_GB
dc.rightsArchived with thanks to Open Forum Infectious Diseasesen_GB
dc.titleChallenges in the management of disseminated progressive histoplasmosis in human immunodeficiency virus-infected patients in resource-limited settingsen
dc.identifier.journalOpen Forum Infectious Diseasesen_GB

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