The contribution of Ebola viral load at admission and other patient characteristics to mortality in a Médecins Sans Frontières (MSF) Ebola Case Management Centre (CMC), Kailahun, Sierra Leone, June -October, 2014

Hdl Handle:
http://hdl.handle.net/10144/560498
Title:
The contribution of Ebola viral load at admission and other patient characteristics to mortality in a Médecins Sans Frontières (MSF) Ebola Case Management Centre (CMC), Kailahun, Sierra Leone, June -October, 2014
Authors:
Fitzpatrick, Gabriel; Vogt, Florian; Gbabai, Osman B Moi; Decroo, Tom; Keane, Marian; De Clerck, Hilde; Grolla, Allen; Brechard, Raphael; Stinson, Kathryn; Van Herp, Michel
Journal:
The Journal of Infectious Diseases
Abstract:
This paper describes patient characteristics, including Ebola viral load, associated with mortality in an MSF Ebola case management centre. Out of 780 admissions between June and October 2014, 525 (67%) were positive for Ebola with a known outcome. The crude mortality rate was 51% (270/525). Ebola viral load (whole blood sample) data was available on 76% (397/525) of patients. Univariate analysis indicated viral load at admission, age, symptom duration prior to admission and distance travelled to the CMC were associated with mortality (p value<0.05). The multivariable model predicted mortality in those with a viral load at admission greater than 10 million copies per millilitre (p value<0.05, Odds Ratio>10), aged 50 years or more (p value=0.08, Odds Ratio=2) and symptom duration prior to admission less than 5 days (p value=0.14). The presence of confusion, diarrhoea and conjunctivitis were significantly higher (p value<0.05) in Ebola patients who died. These findings highlight the importance viral load at admission has on mortality outcomes and could be used to cohort cases with viral loads greater than 10 million copies into dedicated wards with more intensive medical support to further reduce mortality.
Publisher:
Oxford University Press
Issue Date:
22-May-2015
URI:
http://hdl.handle.net/10144/560498
DOI:
10.1093/infdis/jiv304
PubMed ID:
26002981
Language:
en
ISSN:
1537-6613
Appears in Collections:
Other Diseases

Full metadata record

DC FieldValue Language
dc.contributor.authorFitzpatrick, Gabrielen_GB
dc.contributor.authorVogt, Florianen_GB
dc.contributor.authorGbabai, Osman B Moien_GB
dc.contributor.authorDecroo, Tomen_GB
dc.contributor.authorKeane, Marianen_GB
dc.contributor.authorDe Clerck, Hildeen_GB
dc.contributor.authorGrolla, Allenen_GB
dc.contributor.authorBrechard, Raphaelen_GB
dc.contributor.authorStinson, Kathrynen_GB
dc.contributor.authorVan Herp, Michelen_GB
dc.date.accessioned2015-07-15T18:05:20Z-
dc.date.available2015-07-15T18:05:20Z-
dc.date.issued2015-05-22-
dc.identifier.citationThe contribution of Ebola viral load at admission and other patient characteristics to mortality in a Médecins Sans Frontières (MSF) Ebola Case Management Centre (CMC), Kailahun, Sierra Leone, June -October, 2014. 2015: J. Infect. Dis.en_GB
dc.identifier.issn1537-6613-
dc.identifier.pmid26002981-
dc.identifier.doi10.1093/infdis/jiv304-
dc.identifier.urihttp://hdl.handle.net/10144/560498-
dc.description.abstractThis paper describes patient characteristics, including Ebola viral load, associated with mortality in an MSF Ebola case management centre. Out of 780 admissions between June and October 2014, 525 (67%) were positive for Ebola with a known outcome. The crude mortality rate was 51% (270/525). Ebola viral load (whole blood sample) data was available on 76% (397/525) of patients. Univariate analysis indicated viral load at admission, age, symptom duration prior to admission and distance travelled to the CMC were associated with mortality (p value<0.05). The multivariable model predicted mortality in those with a viral load at admission greater than 10 million copies per millilitre (p value<0.05, Odds Ratio>10), aged 50 years or more (p value=0.08, Odds Ratio=2) and symptom duration prior to admission less than 5 days (p value=0.14). The presence of confusion, diarrhoea and conjunctivitis were significantly higher (p value<0.05) in Ebola patients who died. These findings highlight the importance viral load at admission has on mortality outcomes and could be used to cohort cases with viral loads greater than 10 million copies into dedicated wards with more intensive medical support to further reduce mortality.en_GB
dc.languageENG-
dc.language.isoenen
dc.publisherOxford University Pressen_GB
dc.rightsPublished by Infectious Diseases Society of America Archived on this site with permission and copyright 2015 by the Infectious Diseases Society of America, [url] and Oxford University Press's Open Access optionen_GB
dc.titleThe contribution of Ebola viral load at admission and other patient characteristics to mortality in a Médecins Sans Frontières (MSF) Ebola Case Management Centre (CMC), Kailahun, Sierra Leone, June -October, 2014en
dc.identifier.journalThe Journal of Infectious Diseasesen_GB
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