A multi-center, open-label trial to compare the efficacy and pharmacokinetics of Artemether-Lumefantrine in children with severe acute malnutrition versus children without severe acute malnutrition: study protocol for the MAL-NUT study

Hdl Handle:
http://hdl.handle.net/10144/560502
Title:
A multi-center, open-label trial to compare the efficacy and pharmacokinetics of Artemether-Lumefantrine in children with severe acute malnutrition versus children without severe acute malnutrition: study protocol for the MAL-NUT study
Authors:
Denoeud-Ndam, Lise; Dicko, Alassane; Baudin, Elisabeth; Guindo, Ousmane; Grandesso, Francesco; Sagara, Issaka; Lasry, Estrella; Palma, Pedro Pablo; Parra, Angeles M Lima; Stepniewska, Kasia; Djimde, Abdoulaye A; Barnes, Karen I; Doumbo, Ogobara K; Etard, Jean-François
Journal:
BMC Infectious Diseases
Abstract:
Malnutrition and malaria frequently coexist in sub-Saharan African countries. Studies on efficacy of antimalarial treatments usually follow the WHO standardized protocol in which severely malnourished children are systematically excluded. Few studies have assessed the efficacy of chloroquine, sulfadoxine-pyrimethamine and quinine in severe acute malnourished children. Overall, efficacy of these treatments appeared to be reduced, attributed to lower immunity and for some antimalarials altered pharmacokinetic profiles and lower drug concentrations. However, similar research on the efficacy and pharmacokinetic profiles of artemisinin-combination therapies (ACTs) and especially artemether-lumefantrine in malnourished children is currently lacking. The main objective of this study is to assess whether artemether-lumefantrine is less efficacious in children suffering from severe acute malnutrition (SAM) compared to non-SAM children, and if so, to what extent this can be attributed to a sub-optimal pharmacokinetic profile.
Publisher:
BioMed Central
Issue Date:
12-Jun-2015
URI:
http://hdl.handle.net/10144/560502
DOI:
10.1186/s12879-015-0963-3
PubMed ID:
26068100
Language:
en
ISSN:
1471-2334
Appears in Collections:
Malaria

Full metadata record

DC FieldValue Language
dc.contributor.authorDenoeud-Ndam, Liseen_GB
dc.contributor.authorDicko, Alassaneen_GB
dc.contributor.authorBaudin, Elisabethen_GB
dc.contributor.authorGuindo, Ousmaneen_GB
dc.contributor.authorGrandesso, Francescoen_GB
dc.contributor.authorSagara, Issakaen_GB
dc.contributor.authorLasry, Estrellaen_GB
dc.contributor.authorPalma, Pedro Pabloen_GB
dc.contributor.authorParra, Angeles M Limaen_GB
dc.contributor.authorStepniewska, Kasiaen_GB
dc.contributor.authorDjimde, Abdoulaye Aen_GB
dc.contributor.authorBarnes, Karen Ien_GB
dc.contributor.authorDoumbo, Ogobara Ken_GB
dc.contributor.authorEtard, Jean-Françoisen_GB
dc.date.accessioned2015-07-15T18:51:24Z-
dc.date.available2015-07-15T18:51:24Z-
dc.date.issued2015-06-12-
dc.identifier.citationA multi-center, open-label trial to compare the efficacy and pharmacokinetics of Artemether-Lumefantrine in children with severe acute malnutrition versus children without severe acute malnutrition: study protocol for the MAL-NUT study. 2015, 15 (1):228 BMC Infect. Dis.en_GB
dc.identifier.issn1471-2334-
dc.identifier.pmid26068100-
dc.identifier.doi10.1186/s12879-015-0963-3-
dc.identifier.urihttp://hdl.handle.net/10144/560502-
dc.description.abstractMalnutrition and malaria frequently coexist in sub-Saharan African countries. Studies on efficacy of antimalarial treatments usually follow the WHO standardized protocol in which severely malnourished children are systematically excluded. Few studies have assessed the efficacy of chloroquine, sulfadoxine-pyrimethamine and quinine in severe acute malnourished children. Overall, efficacy of these treatments appeared to be reduced, attributed to lower immunity and for some antimalarials altered pharmacokinetic profiles and lower drug concentrations. However, similar research on the efficacy and pharmacokinetic profiles of artemisinin-combination therapies (ACTs) and especially artemether-lumefantrine in malnourished children is currently lacking. The main objective of this study is to assess whether artemether-lumefantrine is less efficacious in children suffering from severe acute malnutrition (SAM) compared to non-SAM children, and if so, to what extent this can be attributed to a sub-optimal pharmacokinetic profile.en_GB
dc.language.isoenen
dc.publisherBioMed Centralen_GB
dc.rightsArchived with thanks to BMC Infectious Diseasesen_GB
dc.titleA multi-center, open-label trial to compare the efficacy and pharmacokinetics of Artemether-Lumefantrine in children with severe acute malnutrition versus children without severe acute malnutrition: study protocol for the MAL-NUT studyen
dc.identifier.journalBMC Infectious Diseasesen_GB

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