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Title: Biological diagnosis of meningococcal meningitis in the African meningitis belt: current epidemic strategy and new perspectives.
Authors: Chanteau, Suzanne
Rose, Angela M C
Djibo, Saacou
Nato, Farida
Boisier, Pascal
Affiliation: CERMES, Réseau International Institut Pasteur, PO Box 10887, Niamey, Niger. schanteau@cermes.org
Citation: Biological diagnosis of meningococcal meningitis in the African meningitis belt: current epidemic strategy and new perspectives. 2007, 25 Suppl 1:A30-6 Vaccine
Publisher: Elsevier
Journal: Vaccine
Issue Date: 3-Sep-2007
URI: http://hdl.handle.net/10144/56173
DOI: 10.1016/j.vaccine.2007.04.037
PubMed ID: 17517452
Additional Links: http://www.sciencedirect.com/science/journal/0264410X
Abstract: Laboratory diagnosis is an essential component in surveillance of meningococcal epidemics, as it can inform decision-makers of the Neisseria meningitidis serogroup(s) involved and the most appropriate vaccine to be selected for mass vaccination. However, countries most affected face real limitations in laboratory diagnostics, due to lack of resources. We describe current diagnostic tools and examine their cost-effectiveness for use in an epidemic context. The conclusion is that current WHO recommendations to use only the latex agglutination assay (Pastorex) at epidemic onset is cost-effective, but recently developed rapid diagnostic tests for the major epidemic-causing meningococcal serogroups may prove a breakthrough for the future.
Type: Article
Language: en
MeSH: Africa
Humans
Latex Fixation Tests
Leukocyte Count
Meningitis, Meningococcal
Polymerase Chain Reaction
Reproducibility of Results
Sensitivity and Specificity
ISSN: 0264-410X
Sponsors: Epicentre
Rights: Published by Elsevier Archived on this site with kind permission and copyright 2007 from Elsevier
Appears in topics: Other Diseases
Laboratory

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