Temporal and spatial analysis of the 2014-2015 Ebola virus outbreak in West Africa

Hdl Handle:
http://hdl.handle.net/10144/575409
Title:
Temporal and spatial analysis of the 2014-2015 Ebola virus outbreak in West Africa
Authors:
Carroll, Miles W; Matthews, David A; Hiscox, Julian A; Elmore, Michael J; Pollakis, Georgios; Rambaut, Andrew; Hewson, Roger; García-Dorival, Isabel; Bore, Joseph Akoi; Koundouno, Raymond; Abdellati, Saïd; Afrough, Babak; Aiyepada, John; Akhilomen, Patience; Asogun, Danny; Atkinson, Barry; Badusche, Marlis; Bah, Amadou; Bate, Simon; Baumann, Jan; Becker, Dirk; Becker-Ziaja, Beate; Bocquin, Anne; Borremans, Benny; Bosworth, Andrew; Boettcher, Jan Peter; Cannas, Angela; Carletti, Fabrizio; Castilletti, Concetta; Clark, Simon; Colavita, Francesca; Diederich, Sandra; Donatus, Adomeh; Duraffour, Sophie; Ehichioya, Deborah; Ellerbrok, Heinz; Fenandez-Garcia, Maria Dolores; Fizet, Alexandra; Fleischmann, Erna; Gryseels, Sophie; Hermelink, Antje; Hinzmann, Julia; Hopf-Guevara, Ute; Ighodalo, Yemisi; Jameson, Lisa; Kelterbaum, Anne; Kis, Zoltan; Kloth, Stefan; Kohl, Claudia; Korva, Miša; Kraus, Annette; Kuisma, Eeva; Kurth, Andreas; Liedigk, Britta; Logue, Christopher H; Lüdtke, Anja; Maes, Piet; McCowen, James; Mély, Stéphane; Mertens, Marc; Meschi, Silvia; Meyer, Benjamin; Michel, Janine; Molkenthin, Peter; Muñoz-Fontela, César; Muth, Doreen; Newman, Edmund N C; Ngabo, Didier; Oestereich, Lisa; Okosun, Jennifer; Olokor, Thomas; Omiunu, Racheal; Omomoh, Emmanuel; Pallasch, Elisa; Pályi, Bernadett; Portmann, Jasmine; Pottage, Thomas; Pratt, Catherine; Priesnitz, Simone; Quartu, Serena; Rappe, Julie; Repits, Johanna; Richter, Martin; Rudolf, Martin; Sachse, Andreas; Schmidt, Kristina Maria; Schudt, Gordian; Strecker, Thomas; Thom, Ruth; Thomas, Stephen; Tobin, Ekaete; Tolley, Howard; Trautner, Jochen; Vermoesen, Tine; Vitoriano, Inês; Wagner, Matthias; Wolff, Svenja; Yue, Constanze; Capobianchi, Maria Rosaria; Kretschmer, Birte; Hall, Yper; Kenny, John G; Rickett, Natasha Y; Dudas, Gytis; Coltart, Cordelia E M; Kerber, Romy; Steer, Damien; Wright, Callum; Senyah, Francis; Keita, Sakoba; Drury, Patrick; Diallo, Boubacar; de Clerck, Hilde; Van Herp, Michel; Sprecher, Armand; Traore, Alexis; Diakite, Mandiou; Konde, Mandy Kader; Koivogui, Lamine; Magassouba, N'Faly; Avšič-Županc, Tatjana; Nitsche, Andreas; Strasser, Marc; Ippolito, Giuseppe; Becker, Stephan; Stoecker, Kilian; Gabriel, Martin; Raoul, Hervé; Di Caro, Antonino; Wölfel, Roman; Formenty, Pierre; Günther, Stephan
Journal:
Nature
Abstract:
West Africa is currently witnessing the most extensive Ebola virus (EBOV) outbreak so far recorded. Until now, there have been 27,013 reported cases and 11,134 deaths. The origin of the virus is thought to have been a zoonotic transmission from a bat to a twoyear-old boy in December 2013 (ref. 2). From this index case the virus was spread by human-to-human contact throughout Guinea, Sierra Leone and Liberia. However, the origin of the particular virus in each country and time of transmission is not known and currently relies on epidemiological analysis, which may be unreliable owing to the difficulties of obtaining patient information. Here we trace the genetic evolution of EBOV in the current outbreak that has resulted in multiple lineages. Deep sequencing of 179 patient samples processed by the European Mobile Laboratory, the first diagnostics unit to be deployed to the epicentre of the outbreak in Guinea, reveals an epidemiological and evolutionary history of the epidemic from March 2014 to January 2015. Analysis of EBOV genome evolution has also benefited from a similar sequencing effort of patient samples from Sierra Leone. Our results confirm that the EBOV from Guinea moved into Sierra Leone, most likely in April or early May. The viruses of the Guinea/Sierra Leone lineage mixed around June/July 2014. Viral sequences covering August, September and October 2014 indicate that this lineage evolved independently within Guinea. These data can be used in conjunction with epidemiological information to test retrospectively the effectiveness of control measures, and provides an unprecedented window into the evolution of an ongoing viral haemorrhagic fever outbreak.
Publisher:
Macmillan
Issue Date:
17-Jun-2015
URI:
http://hdl.handle.net/10144/575409
DOI:
10.1038/nature14594
PubMed ID:
26083749
Language:
en
ISSN:
1476-4687
Appears in Collections:
Other Diseases

Full metadata record

DC FieldValue Language
dc.contributor.authorCarroll, Miles Wen_GB
dc.contributor.authorMatthews, David Aen_GB
dc.contributor.authorHiscox, Julian Aen_GB
dc.contributor.authorElmore, Michael Jen_GB
dc.contributor.authorPollakis, Georgiosen_GB
dc.contributor.authorRambaut, Andrewen_GB
dc.contributor.authorHewson, Rogeren_GB
dc.contributor.authorGarcía-Dorival, Isabelen_GB
dc.contributor.authorBore, Joseph Akoien_GB
dc.contributor.authorKoundouno, Raymonden_GB
dc.contributor.authorAbdellati, Saïden_GB
dc.contributor.authorAfrough, Babaken_GB
dc.contributor.authorAiyepada, Johnen_GB
dc.contributor.authorAkhilomen, Patienceen_GB
dc.contributor.authorAsogun, Dannyen_GB
dc.contributor.authorAtkinson, Barryen_GB
dc.contributor.authorBadusche, Marlisen_GB
dc.contributor.authorBah, Amadouen_GB
dc.contributor.authorBate, Simonen_GB
dc.contributor.authorBaumann, Janen_GB
dc.contributor.authorBecker, Dirken_GB
dc.contributor.authorBecker-Ziaja, Beateen_GB
dc.contributor.authorBocquin, Anneen_GB
dc.contributor.authorBorremans, Bennyen_GB
dc.contributor.authorBosworth, Andrewen_GB
dc.contributor.authorBoettcher, Jan Peteren_GB
dc.contributor.authorCannas, Angelaen_GB
dc.contributor.authorCarletti, Fabrizioen_GB
dc.contributor.authorCastilletti, Concettaen_GB
dc.contributor.authorClark, Simonen_GB
dc.contributor.authorColavita, Francescaen_GB
dc.contributor.authorDiederich, Sandraen_GB
dc.contributor.authorDonatus, Adomehen_GB
dc.contributor.authorDuraffour, Sophieen_GB
dc.contributor.authorEhichioya, Deborahen_GB
dc.contributor.authorEllerbrok, Heinzen_GB
dc.contributor.authorFenandez-Garcia, Maria Doloresen_GB
dc.contributor.authorFizet, Alexandraen_GB
dc.contributor.authorFleischmann, Ernaen_GB
dc.contributor.authorGryseels, Sophieen_GB
dc.contributor.authorHermelink, Antjeen_GB
dc.contributor.authorHinzmann, Juliaen_GB
dc.contributor.authorHopf-Guevara, Uteen_GB
dc.contributor.authorIghodalo, Yemisien_GB
dc.contributor.authorJameson, Lisaen_GB
dc.contributor.authorKelterbaum, Anneen_GB
dc.contributor.authorKis, Zoltanen_GB
dc.contributor.authorKloth, Stefanen_GB
dc.contributor.authorKohl, Claudiaen_GB
dc.contributor.authorKorva, Mišaen_GB
dc.contributor.authorKraus, Annetteen_GB
dc.contributor.authorKuisma, Eevaen_GB
dc.contributor.authorKurth, Andreasen_GB
dc.contributor.authorLiedigk, Brittaen_GB
dc.contributor.authorLogue, Christopher Hen_GB
dc.contributor.authorLüdtke, Anjaen_GB
dc.contributor.authorMaes, Pieten_GB
dc.contributor.authorMcCowen, Jamesen_GB
dc.contributor.authorMély, Stéphaneen_GB
dc.contributor.authorMertens, Marcen_GB
dc.contributor.authorMeschi, Silviaen_GB
dc.contributor.authorMeyer, Benjaminen_GB
dc.contributor.authorMichel, Janineen_GB
dc.contributor.authorMolkenthin, Peteren_GB
dc.contributor.authorMuñoz-Fontela, Césaren_GB
dc.contributor.authorMuth, Doreenen_GB
dc.contributor.authorNewman, Edmund N Cen_GB
dc.contributor.authorNgabo, Didieren_GB
dc.contributor.authorOestereich, Lisaen_GB
dc.contributor.authorOkosun, Jenniferen_GB
dc.contributor.authorOlokor, Thomasen_GB
dc.contributor.authorOmiunu, Rachealen_GB
dc.contributor.authorOmomoh, Emmanuelen_GB
dc.contributor.authorPallasch, Elisaen_GB
dc.contributor.authorPályi, Bernadetten_GB
dc.contributor.authorPortmann, Jasmineen_GB
dc.contributor.authorPottage, Thomasen_GB
dc.contributor.authorPratt, Catherineen_GB
dc.contributor.authorPriesnitz, Simoneen_GB
dc.contributor.authorQuartu, Serenaen_GB
dc.contributor.authorRappe, Julieen_GB
dc.contributor.authorRepits, Johannaen_GB
dc.contributor.authorRichter, Martinen_GB
dc.contributor.authorRudolf, Martinen_GB
dc.contributor.authorSachse, Andreasen_GB
dc.contributor.authorSchmidt, Kristina Mariaen_GB
dc.contributor.authorSchudt, Gordianen_GB
dc.contributor.authorStrecker, Thomasen_GB
dc.contributor.authorThom, Ruthen_GB
dc.contributor.authorThomas, Stephenen_GB
dc.contributor.authorTobin, Ekaeteen_GB
dc.contributor.authorTolley, Howarden_GB
dc.contributor.authorTrautner, Jochenen_GB
dc.contributor.authorVermoesen, Tineen_GB
dc.contributor.authorVitoriano, Inêsen_GB
dc.contributor.authorWagner, Matthiasen_GB
dc.contributor.authorWolff, Svenjaen_GB
dc.contributor.authorYue, Constanzeen_GB
dc.contributor.authorCapobianchi, Maria Rosariaen_GB
dc.contributor.authorKretschmer, Birteen_GB
dc.contributor.authorHall, Yperen_GB
dc.contributor.authorKenny, John Gen_GB
dc.contributor.authorRickett, Natasha Yen_GB
dc.contributor.authorDudas, Gytisen_GB
dc.contributor.authorColtart, Cordelia E Men_GB
dc.contributor.authorKerber, Romyen_GB
dc.contributor.authorSteer, Damienen_GB
dc.contributor.authorWright, Callumen_GB
dc.contributor.authorSenyah, Francisen_GB
dc.contributor.authorKeita, Sakobaen_GB
dc.contributor.authorDrury, Patricken_GB
dc.contributor.authorDiallo, Boubacaren_GB
dc.contributor.authorde Clerck, Hildeen_GB
dc.contributor.authorVan Herp, Michelen_GB
dc.contributor.authorSprecher, Armanden_GB
dc.contributor.authorTraore, Alexisen_GB
dc.contributor.authorDiakite, Mandiouen_GB
dc.contributor.authorKonde, Mandy Kaderen_GB
dc.contributor.authorKoivogui, Lamineen_GB
dc.contributor.authorMagassouba, N'Falyen_GB
dc.contributor.authorAvšič-Županc, Tatjanaen_GB
dc.contributor.authorNitsche, Andreasen_GB
dc.contributor.authorStrasser, Marcen_GB
dc.contributor.authorIppolito, Giuseppeen_GB
dc.contributor.authorBecker, Stephanen_GB
dc.contributor.authorStoecker, Kilianen_GB
dc.contributor.authorGabriel, Martinen_GB
dc.contributor.authorRaoul, Hervéen_GB
dc.contributor.authorDi Caro, Antoninoen_GB
dc.contributor.authorWölfel, Romanen_GB
dc.contributor.authorFormenty, Pierreen_GB
dc.contributor.authorGünther, Stephanen_GB
dc.date.accessioned2015-08-20T18:41:48Z-
dc.date.available2015-08-20T18:41:48Z-
dc.date.issued2015-06-17-
dc.identifier.citationTemporal and spatial analysis of the 2014-2015 Ebola virus outbreak in West Africa. 2015: Natureen_GB
dc.identifier.issn1476-4687-
dc.identifier.pmid26083749-
dc.identifier.doi10.1038/nature14594-
dc.identifier.urihttp://hdl.handle.net/10144/575409-
dc.description.abstractWest Africa is currently witnessing the most extensive Ebola virus (EBOV) outbreak so far recorded. Until now, there have been 27,013 reported cases and 11,134 deaths. The origin of the virus is thought to have been a zoonotic transmission from a bat to a twoyear-old boy in December 2013 (ref. 2). From this index case the virus was spread by human-to-human contact throughout Guinea, Sierra Leone and Liberia. However, the origin of the particular virus in each country and time of transmission is not known and currently relies on epidemiological analysis, which may be unreliable owing to the difficulties of obtaining patient information. Here we trace the genetic evolution of EBOV in the current outbreak that has resulted in multiple lineages. Deep sequencing of 179 patient samples processed by the European Mobile Laboratory, the first diagnostics unit to be deployed to the epicentre of the outbreak in Guinea, reveals an epidemiological and evolutionary history of the epidemic from March 2014 to January 2015. Analysis of EBOV genome evolution has also benefited from a similar sequencing effort of patient samples from Sierra Leone. Our results confirm that the EBOV from Guinea moved into Sierra Leone, most likely in April or early May. The viruses of the Guinea/Sierra Leone lineage mixed around June/July 2014. Viral sequences covering August, September and October 2014 indicate that this lineage evolved independently within Guinea. These data can be used in conjunction with epidemiological information to test retrospectively the effectiveness of control measures, and provides an unprecedented window into the evolution of an ongoing viral haemorrhagic fever outbreak.en_GB
dc.languageENG-
dc.language.isoenen
dc.publisherMacmillanen_GB
dc.rightsArchived on this site with permission from Macmillan Publishers' Ltd. open accessen_GB
dc.titleTemporal and spatial analysis of the 2014-2015 Ebola virus outbreak in West Africaen
dc.identifier.journalNatureen_GB

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