Prognostic Indicators for Ebola Patient Survival

Hdl Handle:
http://hdl.handle.net/10144/600284
Title:
Prognostic Indicators for Ebola Patient Survival
Authors:
Crowe, SJ; Maenner, MJ; Kuah, S; Erickson, BR; Coffee, M; Knust, B; Klena, J; Foday, J; Hertz, D; Hermans, V; Achar, J; Caleo, GM; Van Herp, M; Albariño, CG; Amman, B; Basile, AJ; Bearden, S; Belser, JA; Bergeron, E; Blau, D; Brault, AC; Campbell, S; Flint, M; Gibbons, A; Goodman, C; McMullan, L; Paddock, C; Russell, B; Salzer, JS; Sanchez, A; Sealy, T; Wang, D; Saffa, G; Turay, A; Nichol, ST; Towner, JS
Journal:
Emerging Infectious Diseases
Abstract:
To determine whether 2 readily available indicators predicted survival among patients with Ebola virus disease in Sierra Leone, we evaluated information for 216 of the 227 patients in Bo District during a 4-month period. The indicators were time from symptom onset to healthcare facility admission and quantitative real-time reverse transcription PCR cycle threshold (Ct), a surrogate for viral load, in first Ebola virus-positive blood sample tested. Of these patients, 151 were alive when detected and had reported healthcare facility admission dates and Ct values available. Time from symptom onset to healthcare facility admission was not associated with survival, but viral load in the first Ebola virus-positive blood sample was inversely associated with survival: 52 (87%) of 60 patients with a Ct of >24 survived and 20 (22%) of 91 with a Ct of <24 survived. Ct values may be useful for clinicians making treatment decisions or managing patient or family expectations.
Publisher:
Center for Disease Control
Issue Date:
1-Feb-2016
URI:
http://hdl.handle.net/10144/600284
DOI:
10.3201/eid2202.151250
PubMed ID:
26812579
Type:
Article
Language:
en
ISSN:
1080-6059
Appears in Collections:
Other Diseases

Full metadata record

DC FieldValue Language
dc.contributor.authorCrowe, SJen
dc.contributor.authorMaenner, MJen
dc.contributor.authorKuah, Sen
dc.contributor.authorErickson, BRen
dc.contributor.authorCoffee, Men
dc.contributor.authorKnust, Ben
dc.contributor.authorKlena, Jen
dc.contributor.authorFoday, Jen
dc.contributor.authorHertz, Den
dc.contributor.authorHermans, Ven
dc.contributor.authorAchar, Jen
dc.contributor.authorCaleo, GMen
dc.contributor.authorVan Herp, Men
dc.contributor.authorAlbariño, CGen
dc.contributor.authorAmman, Ben
dc.contributor.authorBasile, AJen
dc.contributor.authorBearden, Sen
dc.contributor.authorBelser, JAen
dc.contributor.authorBergeron, Een
dc.contributor.authorBlau, Den
dc.contributor.authorBrault, ACen
dc.contributor.authorCampbell, Sen
dc.contributor.authorFlint, Men
dc.contributor.authorGibbons, Aen
dc.contributor.authorGoodman, Cen
dc.contributor.authorMcMullan, Len
dc.contributor.authorPaddock, Cen
dc.contributor.authorRussell, Ben
dc.contributor.authorSalzer, JSen
dc.contributor.authorSanchez, Aen
dc.contributor.authorSealy, Ten
dc.contributor.authorWang, Den
dc.contributor.authorSaffa, Gen
dc.contributor.authorTuray, Aen
dc.contributor.authorNichol, STen
dc.contributor.authorTowner, JSen
dc.date.accessioned2016-02-28T13:52:07Zen
dc.date.available2016-02-28T13:52:07Zen
dc.date.issued2016-02-01en
dc.identifier.citationPrognostic Indicators for Ebola Patient Survival. 2016, 22 (2):217-23 Emerging Infect. Dis.en
dc.identifier.issn1080-6059en
dc.identifier.pmid26812579en
dc.identifier.doi10.3201/eid2202.151250en
dc.identifier.urihttp://hdl.handle.net/10144/600284en
dc.description.abstractTo determine whether 2 readily available indicators predicted survival among patients with Ebola virus disease in Sierra Leone, we evaluated information for 216 of the 227 patients in Bo District during a 4-month period. The indicators were time from symptom onset to healthcare facility admission and quantitative real-time reverse transcription PCR cycle threshold (Ct), a surrogate for viral load, in first Ebola virus-positive blood sample tested. Of these patients, 151 were alive when detected and had reported healthcare facility admission dates and Ct values available. Time from symptom onset to healthcare facility admission was not associated with survival, but viral load in the first Ebola virus-positive blood sample was inversely associated with survival: 52 (87%) of 60 patients with a Ct of >24 survived and 20 (22%) of 91 with a Ct of <24 survived. Ct values may be useful for clinicians making treatment decisions or managing patient or family expectations.en
dc.language.isoenen
dc.publisherCenter for Disease Controlen
dc.rightsPublished by Centers for Disease Control (CDC) Archived on this site by permission of CDC, [url]http://www.cdc.gov/ncidod/eid[/url]en
dc.titlePrognostic Indicators for Ebola Patient Survivalen
dc.typeArticleen
dc.identifier.journalEmerging Infectious Diseasesen

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