Dilution Testing Using Rapid Diagnostic Tests in a HIV Diagnostic Algorithm: a Novel Alternative for Confirmation Testing in Resource Limited Settings

Hdl Handle:
http://hdl.handle.net/10144/600287
Title:
Dilution Testing Using Rapid Diagnostic Tests in a HIV Diagnostic Algorithm: a Novel Alternative for Confirmation Testing in Resource Limited Settings
Authors:
Shanks, L; Siddiqui, MR; Abebe, A; Piriou, E; Pearce, N; Ariti, C; Masiga, J; Muluneh, L; Wazome, J; Ritmeijer, K; Klarkowski, D
Journal:
Virology Journal
Abstract:
Current WHO testing guidelines for resource limited settings diagnose HIV on the basis of screening tests without a confirmation test due to cost constraints. This leads to a potential risk of false positive HIV diagnosis. In this paper, we evaluate the dilution test, a novel method for confirmation testing, which is simple, rapid, and low cost. The principle of the dilution test is to alter the sensitivity of a rapid diagnostic test (RDT) by dilution of the sample, in order to screen out the cross reacting antibodies responsible for falsely positive RDT results.
Publisher:
BioMed Central
Issue Date:
14-May-2015
URI:
http://hdl.handle.net/10144/600287
DOI:
10.1186/s12985-015-0306-4
PubMed ID:
25972188
Type:
Article
Language:
en
ISSN:
1743-422X
Appears in Collections:
HIV/AIDS

Full metadata record

DC FieldValue Language
dc.contributor.authorShanks, Len
dc.contributor.authorSiddiqui, MRen
dc.contributor.authorAbebe, Aen
dc.contributor.authorPiriou, Een
dc.contributor.authorPearce, Nen
dc.contributor.authorAriti, Cen
dc.contributor.authorMasiga, Jen
dc.contributor.authorMuluneh, Len
dc.contributor.authorWazome, Jen
dc.contributor.authorRitmeijer, Ken
dc.contributor.authorKlarkowski, Den
dc.date.accessioned2016-02-28T14:03:09Zen
dc.date.available2016-02-28T14:03:09Zen
dc.date.issued2015-05-14en
dc.identifier.citationDilution testing using rapid diagnostic tests in a HIV diagnostic algorithm: a novel alternative for confirmation testing in resource limited settings. 2015, 12:75 Virol. J.en
dc.identifier.issn1743-422Xen
dc.identifier.pmid25972188en
dc.identifier.doi10.1186/s12985-015-0306-4en
dc.identifier.urihttp://hdl.handle.net/10144/600287en
dc.description.abstractCurrent WHO testing guidelines for resource limited settings diagnose HIV on the basis of screening tests without a confirmation test due to cost constraints. This leads to a potential risk of false positive HIV diagnosis. In this paper, we evaluate the dilution test, a novel method for confirmation testing, which is simple, rapid, and low cost. The principle of the dilution test is to alter the sensitivity of a rapid diagnostic test (RDT) by dilution of the sample, in order to screen out the cross reacting antibodies responsible for falsely positive RDT results.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.rightsArchived with thanks to Virology Journalen
dc.titleDilution Testing Using Rapid Diagnostic Tests in a HIV Diagnostic Algorithm: a Novel Alternative for Confirmation Testing in Resource Limited Settingsen
dc.typeArticleen
dc.identifier.journalVirology Journalen

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