Essentials of Filoviral Load Quantification

Hdl Handle:
http://hdl.handle.net/10144/613522
Title:
Essentials of Filoviral Load Quantification
Authors:
Cnops, L; van Griensven, J; Honko, AN; Bausch, DG; Sprecher, A; Hill, CE; Colebunders, R; Johnson, JC; Griffiths, A; Palacios, GF; Kraft, CS; Kobinger, G; Hewlett, A; Norwood, DA; Sabeti, P; Jahrling, PB; Formenty, P; Kuhn, JH; Ariën, KK
Journal:
Lancet Infectious Diseases
Abstract:
Quantitative measurement of viral load is an important parameter in the management of filovirus disease outbreaks because viral load correlates with severity of disease, survival, and infectivity. During the ongoing Ebola virus disease outbreak in parts of Western Africa, most assays used in the detection of Ebola virus disease by more than 44 diagnostic laboratories yielded qualitative results. Regulatory hurdles involved in validating quantitative assays and the urgent need for a rapid Ebola virus disease diagnosis precluded development of validated quantitative assays during the outbreak. Because of sparse quantitative data obtained from these outbreaks, opportunities for study of correlations between patient outcome, changes in viral load during the course of an outbreak, disease course in asymptomatic individuals, and the potential for virus transmission between infected patients and contacts have been limited. We strongly urge the continued development of quantitative viral load assays to carefully evaluate these parameters in future outbreaks of filovirus disease.
Publisher:
Elsevier
Issue Date:
10-Jun-2016
URI:
http://hdl.handle.net/10144/613522
DOI:
10.1016/S1473-3099(16)30063-9
PubMed ID:
27296694
Submitted date:
2016-06-15
Language:
en
ISSN:
1474-4457
Appears in Collections:
Other Diseases

Full metadata record

DC FieldValue Language
dc.contributor.authorCnops, Len
dc.contributor.authorvan Griensven, Jen
dc.contributor.authorHonko, ANen
dc.contributor.authorBausch, DGen
dc.contributor.authorSprecher, Aen
dc.contributor.authorHill, CEen
dc.contributor.authorColebunders, Ren
dc.contributor.authorJohnson, JCen
dc.contributor.authorGriffiths, Aen
dc.contributor.authorPalacios, GFen
dc.contributor.authorKraft, CSen
dc.contributor.authorKobinger, Gen
dc.contributor.authorHewlett, Aen
dc.contributor.authorNorwood, DAen
dc.contributor.authorSabeti, Pen
dc.contributor.authorJahrling, PBen
dc.contributor.authorFormenty, Pen
dc.contributor.authorKuhn, JHen
dc.contributor.authorAriën, KKen
dc.date.accessioned2016-06-16T22:12:12Zen
dc.date.available2016-06-16T22:12:12Zen
dc.date.issued2016-06-10en
dc.date.submitted2016-06-15en
dc.identifier.citationEssentials of filoviral load quantification. 2016: Lancet Infect Disen
dc.identifier.issn1474-4457en
dc.identifier.pmid27296694en
dc.identifier.doi10.1016/S1473-3099(16)30063-9en
dc.identifier.urihttp://hdl.handle.net/10144/613522en
dc.description.abstractQuantitative measurement of viral load is an important parameter in the management of filovirus disease outbreaks because viral load correlates with severity of disease, survival, and infectivity. During the ongoing Ebola virus disease outbreak in parts of Western Africa, most assays used in the detection of Ebola virus disease by more than 44 diagnostic laboratories yielded qualitative results. Regulatory hurdles involved in validating quantitative assays and the urgent need for a rapid Ebola virus disease diagnosis precluded development of validated quantitative assays during the outbreak. Because of sparse quantitative data obtained from these outbreaks, opportunities for study of correlations between patient outcome, changes in viral load during the course of an outbreak, disease course in asymptomatic individuals, and the potential for virus transmission between infected patients and contacts have been limited. We strongly urge the continued development of quantitative viral load assays to carefully evaluate these parameters in future outbreaks of filovirus disease.en
dc.languageENGen
dc.language.isoenen
dc.publisherElsevieren
dc.rightsArchived with thanks to Lancet Infectious Diseasesen
dc.titleEssentials of Filoviral Load Quantificationen
dc.identifier.journalLancet Infectious Diseasesen

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