Convergence of a Diabetes Mellitus, Protein Energy Malnutrition, and TB Epidemic: the Neglected Elderly Population

Hdl Handle:
http://hdl.handle.net/10144/618342
Title:
Convergence of a Diabetes Mellitus, Protein Energy Malnutrition, and TB Epidemic: the Neglected Elderly Population
Authors:
Menon, S; Rossi, R; Nshimyumukiza, L; Wusiman, A; Zdraveska, N; Eldin, MS
Journal:
BMC Infectious Diseases
Abstract:
On a global scale, nearly two billion persons are infected with Mycobacterium tuberculosis. From this vast reservoir of latent tuberculosis (TB) infection, a substantial number will develop active TB during their lifetime, with some being able to transmit TB or Multi-drug- resistant (MDR) TB to others. There is clinical evidence pointing to a higher prevalence of infectious diseases including TB among individuals with Diabetes Mellitus (DM). Furthermore, ageing and diabetes mellitus may further aggravate protein-energy malnutrition (PEM), which in turn impairs T-lymphocyte mediated immunologic defenses, thereby increasing the risk of developing active TB and compromising TB treatment. This article aims to a) highlight synergistic mechanisms associated with immunosenescence, DM and PEM in relation to the development of active TB and b) identify nutritional, clinical and epidemiological research gaps.
Publisher:
BioMed Central
Issue Date:
26-Jul-2016
URI:
http://hdl.handle.net/10144/618342
DOI:
10.1186/s12879-016-1718-5
PubMed ID:
27456231
Submitted date:
2016-08-03
Language:
en
ISSN:
1471-2334
Appears in Collections:
TB

Full metadata record

DC FieldValue Language
dc.contributor.authorMenon, Sen
dc.contributor.authorRossi, Ren
dc.contributor.authorNshimyumukiza, Len
dc.contributor.authorWusiman, Aen
dc.contributor.authorZdraveska, Nen
dc.contributor.authorEldin, MSen
dc.date.accessioned2016-08-11T16:15:26Z-
dc.date.available2016-08-11T16:15:26Z-
dc.date.issued2016-07-26-
dc.date.submitted2016-08-03-
dc.identifier.citationConvergence of a diabetes mellitus, protein energy malnutrition, and TB epidemic: the neglected elderly population. 2016, 16 (1):361 BMC Infect. Dis.en
dc.identifier.issn1471-2334-
dc.identifier.pmid27456231-
dc.identifier.doi10.1186/s12879-016-1718-5-
dc.identifier.urihttp://hdl.handle.net/10144/618342-
dc.description.abstractOn a global scale, nearly two billion persons are infected with Mycobacterium tuberculosis. From this vast reservoir of latent tuberculosis (TB) infection, a substantial number will develop active TB during their lifetime, with some being able to transmit TB or Multi-drug- resistant (MDR) TB to others. There is clinical evidence pointing to a higher prevalence of infectious diseases including TB among individuals with Diabetes Mellitus (DM). Furthermore, ageing and diabetes mellitus may further aggravate protein-energy malnutrition (PEM), which in turn impairs T-lymphocyte mediated immunologic defenses, thereby increasing the risk of developing active TB and compromising TB treatment. This article aims to a) highlight synergistic mechanisms associated with immunosenescence, DM and PEM in relation to the development of active TB and b) identify nutritional, clinical and epidemiological research gaps.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.rightsArchived with thanks to BMC Infectious Diseasesen
dc.titleConvergence of a Diabetes Mellitus, Protein Energy Malnutrition, and TB Epidemic: the Neglected Elderly Populationen
dc.identifier.journalBMC Infectious Diseasesen

Related articles on PubMed

All Items in MSF are protected by copyright, with all rights reserved, unless otherwise indicated.