An Optimised Age-Based Dosing Regimen for Single Low-Dose Primaquine For Blocking Malaria Transmission in Cambodia

Hdl Handle:
http://hdl.handle.net/10144/618686
Title:
An Optimised Age-Based Dosing Regimen for Single Low-Dose Primaquine For Blocking Malaria Transmission in Cambodia
Authors:
Leang, R; Khu, NH; Mukaka, M; Debackere, M; Tripura, R; Kheang, ST; Chy, S; Kak, N; Buchy, P; Tarantola, A; Menard, D; Roca-Felterer, A; Fairhurst, RM; Kheng, S; Muth, S; Ngak, S; Dondorp, AM; White, NJ; Taylor, WRJ
Journal:
BMC Medicine
Abstract:
In 2012, the World Health Organization recommended the addition of single low-dose primaquine (SLDPQ, 0.25 mg base/kg body weight) to artemisinin combination therapies to block the transmission of Plasmodium falciparum without testing for glucose-6-phosphate dehydrogenase deficiency. The targeted group was non-pregnant patients aged ≥ 1 year (later changed to ≥ 6 months) with acute uncomplicated falciparum malaria, primarily in countries with artemisinin-resistant P. falciparum (ARPf). No dosing regimen was suggested, leaving malaria control programmes and clinicians in limbo. Therefore, we designed a user-friendly, age-based SLDPQ regimen for Cambodia, the country most affected by ARPf.
Publisher:
BioMed Central
Issue Date:
27-Oct-2016
URI:
http://hdl.handle.net/10144/618686
DOI:
10.1186/s12916-016-0701-8
PubMed ID:
27784313
Submitted date:
2016-10-31
Language:
en
ISSN:
1741-7015
Appears in Collections:
Malaria

Full metadata record

DC FieldValue Language
dc.contributor.authorLeang, Ren
dc.contributor.authorKhu, NHen
dc.contributor.authorMukaka, Men
dc.contributor.authorDebackere, Men
dc.contributor.authorTripura, Ren
dc.contributor.authorKheang, STen
dc.contributor.authorChy, Sen
dc.contributor.authorKak, Nen
dc.contributor.authorBuchy, Pen
dc.contributor.authorTarantola, Aen
dc.contributor.authorMenard, Den
dc.contributor.authorRoca-Felterer, Aen
dc.contributor.authorFairhurst, RMen
dc.contributor.authorKheng, Sen
dc.contributor.authorMuth, Sen
dc.contributor.authorNgak, Sen
dc.contributor.authorDondorp, AMen
dc.contributor.authorWhite, NJen
dc.contributor.authorTaylor, WRJen
dc.date.accessioned2016-11-06T13:09:08Z-
dc.date.available2016-11-06T13:09:08Z-
dc.date.issued2016-10-27-
dc.date.submitted2016-10-31-
dc.identifier.citationAn Optimised Age-Based Dosing Regimen for Single Low-Dose Primaquine For Blocking Malaria Transmission in Cambodia. 2016, 14 (1):171 BMC Meden
dc.identifier.issn1741-7015-
dc.identifier.pmid27784313-
dc.identifier.doi10.1186/s12916-016-0701-8-
dc.identifier.urihttp://hdl.handle.net/10144/618686-
dc.description.abstractIn 2012, the World Health Organization recommended the addition of single low-dose primaquine (SLDPQ, 0.25 mg base/kg body weight) to artemisinin combination therapies to block the transmission of Plasmodium falciparum without testing for glucose-6-phosphate dehydrogenase deficiency. The targeted group was non-pregnant patients aged ≥ 1 year (later changed to ≥ 6 months) with acute uncomplicated falciparum malaria, primarily in countries with artemisinin-resistant P. falciparum (ARPf). No dosing regimen was suggested, leaving malaria control programmes and clinicians in limbo. Therefore, we designed a user-friendly, age-based SLDPQ regimen for Cambodia, the country most affected by ARPf.en
dc.languageENG-
dc.language.isoenen
dc.publisherBioMed Centralen
dc.rightsArchived with thanks to BMC Medicineen
dc.titleAn Optimised Age-Based Dosing Regimen for Single Low-Dose Primaquine For Blocking Malaria Transmission in Cambodiaen
dc.identifier.journalBMC Medicineen

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