Immune Responses to an Oral Cholera Vaccine in Internally Displaced Persons in South Sudan

Hdl Handle:
http://hdl.handle.net/10144/618687
Title:
Immune Responses to an Oral Cholera Vaccine in Internally Displaced Persons in South Sudan
Authors:
Iyer, AS; Bouhenia, M; Rumunu, J; Abubakar, A; Gruninger, RJ; Pita, J; Lino, RL; Deng, LL; Wamala, JF; Ryan, ET; Martin, S; Legros, D; Lessler, J; Sack, DA; Luquero, FJ; Leung, DT; Azman, AS
Journal:
Scientific Reports
Abstract:
Despite recent large-scale cholera outbreaks, little is known about the immunogenicity of oral cholera vaccines (OCV) in African populations, particularly among those at highest cholera risk. During a 2015 preemptive OCV campaign among internally displaced persons in South Sudan, a year after a large cholera outbreak, we enrolled 37 young children (1-5 years old), 67 older children (6-17 years old) and 101 adults (≥18 years old), who received two doses of OCV (Shanchol) spaced approximately 3 weeks apart. Cholera-specific antibody responses were determined at days 0, 21 and 35 post-immunization. High baseline vibriocidal titers (>80) were observed in 21% of the participants, suggesting recent cholera exposure or vaccination. Among those with titers ≤80, 90% young children, 73% older children and 72% adults seroconverted (≥4 fold titer rise) after the 1(st) OCV dose; with no additional seroconversion after the 2(nd) dose. Post-vaccination immunological endpoints did not differ across age groups. Our results indicate Shanchol was immunogenic in this vulnerable population and that a single dose alone may be sufficient to achieve similar short-term immunological responses to the currently licensed two-dose regimen. While we found no evidence of differential response by age, further immunologic and epidemiologic studies are needed.
Publisher:
Nature Publishing Group
Issue Date:
24-Oct-2016
URI:
http://hdl.handle.net/10144/618687
DOI:
10.1038/srep35742
PubMed ID:
27775046
Submitted date:
2016-10-31
Language:
en
ISSN:
2045-2322
Appears in Collections:
Other Diseases

Full metadata record

DC FieldValue Language
dc.contributor.authorIyer, ASen
dc.contributor.authorBouhenia, Men
dc.contributor.authorRumunu, Jen
dc.contributor.authorAbubakar, Aen
dc.contributor.authorGruninger, RJen
dc.contributor.authorPita, Jen
dc.contributor.authorLino, RLen
dc.contributor.authorDeng, LLen
dc.contributor.authorWamala, JFen
dc.contributor.authorRyan, ETen
dc.contributor.authorMartin, Sen
dc.contributor.authorLegros, Den
dc.contributor.authorLessler, Jen
dc.contributor.authorSack, DAen
dc.contributor.authorLuquero, FJen
dc.contributor.authorLeung, DTen
dc.contributor.authorAzman, ASen
dc.date.accessioned2016-11-06T13:10:34Z-
dc.date.available2016-11-06T13:10:34Z-
dc.date.issued2016-10-24-
dc.date.submitted2016-10-31-
dc.identifier.citationImmune Responses to an Oral Cholera Vaccine in Internally Displaced Persons in South Sudan. 2016, 6:35742 Sci Repen
dc.identifier.issn2045-2322-
dc.identifier.pmid27775046-
dc.identifier.doi10.1038/srep35742-
dc.identifier.urihttp://hdl.handle.net/10144/618687-
dc.description.abstractDespite recent large-scale cholera outbreaks, little is known about the immunogenicity of oral cholera vaccines (OCV) in African populations, particularly among those at highest cholera risk. During a 2015 preemptive OCV campaign among internally displaced persons in South Sudan, a year after a large cholera outbreak, we enrolled 37 young children (1-5 years old), 67 older children (6-17 years old) and 101 adults (≥18 years old), who received two doses of OCV (Shanchol) spaced approximately 3 weeks apart. Cholera-specific antibody responses were determined at days 0, 21 and 35 post-immunization. High baseline vibriocidal titers (>80) were observed in 21% of the participants, suggesting recent cholera exposure or vaccination. Among those with titers ≤80, 90% young children, 73% older children and 72% adults seroconverted (≥4 fold titer rise) after the 1(st) OCV dose; with no additional seroconversion after the 2(nd) dose. Post-vaccination immunological endpoints did not differ across age groups. Our results indicate Shanchol was immunogenic in this vulnerable population and that a single dose alone may be sufficient to achieve similar short-term immunological responses to the currently licensed two-dose regimen. While we found no evidence of differential response by age, further immunologic and epidemiologic studies are needed.en
dc.languageENG-
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.rightsArchived with thanks to Scientific reportsen
dc.titleImmune Responses to an Oral Cholera Vaccine in Internally Displaced Persons in South Sudanen
dc.identifier.journalScientific Reportsen

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