Ebola Virus Disease, Democratic Republic of the Congo, 2014

Hdl Handle:
http://hdl.handle.net/10144/618726
Title:
Ebola Virus Disease, Democratic Republic of the Congo, 2014
Authors:
Nanclares, C; Kapetshi, J; Lionetto, F; de la Rosa, O; Tamfun, JJ; Alia, M; Kobinger, G; Bernasconi, A
Journal:
Emerging Infectious Diseases
Abstract:
During July-November 2014, the Democratic Republic of the Congo underwent its seventh Ebola virus disease (EVD) outbreak. The etiologic agent was Zaire Ebola virus; 66 cases were reported (overall case-fatality rate 74.2%). Through a retrospective observational study of confirmed EVD in 25 patients admitted to either of 2 Ebola treatment centers, we described clinical features and investigated correlates associated with death. Clinical features were mainly generic. At admission, 76% of patients had >1 gastrointestinal symptom and 28% >1 hemorrhagic symptom. The case-fatality rate in this group was 48% and was higher for female patients (67%). Cox regression analysis correlated death with initial low cycle threshold, indicating high viral load. Cycle threshold was a robust predictor of death, as were fever, hiccups, diarrhea, dyspnea, dehydration, disorientation, hematemesis, bloody feces during hospitalization, and anorexia in recent medical history. Differences from other outbreaks could suggest guidance for optimizing clinical management and disease control.
Publisher:
Center for Disease Control
Issue Date:
Sep-2016
URI:
http://hdl.handle.net/10144/618726
DOI:
10.3201/eid2209.160354
PubMed ID:
27533284
Language:
en
ISSN:
1080-6059
Appears in Collections:
Other Diseases

Full metadata record

DC FieldValue Language
dc.contributor.authorNanclares, Cen
dc.contributor.authorKapetshi, Jen
dc.contributor.authorLionetto, Fen
dc.contributor.authorde la Rosa, Oen
dc.contributor.authorTamfun, JJen
dc.contributor.authorAlia, Men
dc.contributor.authorKobinger, Gen
dc.contributor.authorBernasconi, Aen
dc.date.accessioned2016-12-09T21:10:49Z-
dc.date.available2016-12-09T21:10:49Z-
dc.date.issued2016-09-
dc.identifier.citationEbola Virus Disease, Democratic Republic of the Congo, 2014. 2016, 22 (9):1579-86 Emerging Infect. Dis.en
dc.identifier.issn1080-6059-
dc.identifier.pmid27533284-
dc.identifier.doi10.3201/eid2209.160354-
dc.identifier.urihttp://hdl.handle.net/10144/618726-
dc.description.abstractDuring July-November 2014, the Democratic Republic of the Congo underwent its seventh Ebola virus disease (EVD) outbreak. The etiologic agent was Zaire Ebola virus; 66 cases were reported (overall case-fatality rate 74.2%). Through a retrospective observational study of confirmed EVD in 25 patients admitted to either of 2 Ebola treatment centers, we described clinical features and investigated correlates associated with death. Clinical features were mainly generic. At admission, 76% of patients had >1 gastrointestinal symptom and 28% >1 hemorrhagic symptom. The case-fatality rate in this group was 48% and was higher for female patients (67%). Cox regression analysis correlated death with initial low cycle threshold, indicating high viral load. Cycle threshold was a robust predictor of death, as were fever, hiccups, diarrhea, dyspnea, dehydration, disorientation, hematemesis, bloody feces during hospitalization, and anorexia in recent medical history. Differences from other outbreaks could suggest guidance for optimizing clinical management and disease control.en
dc.language.isoenen
dc.publisherCenter for Disease Controlen
dc.rightsPublished by Centers for Disease Control (CDC) Archived on this site by permission of CDC, [url]http://www.cdc.gov/ncidod/eid[/url]en
dc.titleEbola Virus Disease, Democratic Republic of the Congo, 2014en
dc.identifier.journalEmerging Infectious Diseasesen

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