Transcriptomic Signatures Differentiate Survival from Fatal Outcomes in Humans Infected with Ebola Virus

Hdl Handle:
http://hdl.handle.net/10144/618767
Title:
Transcriptomic Signatures Differentiate Survival from Fatal Outcomes in Humans Infected with Ebola Virus
Authors:
Liu, X; Speranza, E; Muñoz-Fontela, C; Haldenby, S; Rickett, NY; Garcia-Dorival, I; Fang, Y; Hall, Y; Zekeng, EG; Lüdtke, A; Xia, D; Kerber, R; Krumkamp, R; Duraffour, S; Sissoko, D; Kenny, J; Rockliffe, N; Williamson, ED; Laws, TR; N'Faly, M; Matthews, DA; Günther, S; Cossins, AR; Sprecher, A; Connor, JH; Carroll, MW; Hiscox, JA
Journal:
Genome Biology
Abstract:
In 2014, Western Africa experienced an unanticipated explosion of Ebola virus infections. What distinguishes fatal from non-fatal outcomes remains largely unknown, yet is key to optimising personalised treatment strategies. We used transcriptome data for peripheral blood taken from infected and convalescent recovering patients to identify early stage host factors that are associated with acute illness and those that differentiate patient survival from fatality.
Publisher:
BioMed Central
Issue Date:
19-Jan-2017
URI:
http://hdl.handle.net/10144/618767
DOI:
10.1186/s13059-016-1137-3
PubMed ID:
28100256
Submitted date:
2017-01-25
Language:
en
ISSN:
1474-760X
Appears in Collections:
Other Diseases

Full metadata record

DC FieldValue Language
dc.contributor.authorLiu, Xen
dc.contributor.authorSperanza, Een
dc.contributor.authorMuñoz-Fontela, Cen
dc.contributor.authorHaldenby, Sen
dc.contributor.authorRickett, NYen
dc.contributor.authorGarcia-Dorival, Ien
dc.contributor.authorFang, Yen
dc.contributor.authorHall, Yen
dc.contributor.authorZekeng, EGen
dc.contributor.authorLüdtke, Aen
dc.contributor.authorXia, Den
dc.contributor.authorKerber, Ren
dc.contributor.authorKrumkamp, Ren
dc.contributor.authorDuraffour, Sen
dc.contributor.authorSissoko, Den
dc.contributor.authorKenny, Jen
dc.contributor.authorRockliffe, Nen
dc.contributor.authorWilliamson, EDen
dc.contributor.authorLaws, TRen
dc.contributor.authorN'Faly, Men
dc.contributor.authorMatthews, DAen
dc.contributor.authorGünther, Sen
dc.contributor.authorCossins, ARen
dc.contributor.authorSprecher, Aen
dc.contributor.authorConnor, JHen
dc.contributor.authorCarroll, MWen
dc.contributor.authorHiscox, JAen
dc.date.accessioned2017-01-25T15:55:38Z-
dc.date.available2017-01-25T15:55:38Z-
dc.date.issued2017-01-19-
dc.date.submitted2017-01-25-
dc.identifier.citationTranscriptomic Signatures Differentiate Survival from Fatal Outcomes in Humans Infected with Ebola Virus. 2017, 18 (1):4 Genome Biol.en
dc.identifier.issn1474-760X-
dc.identifier.pmid28100256-
dc.identifier.doi10.1186/s13059-016-1137-3-
dc.identifier.urihttp://hdl.handle.net/10144/618767-
dc.description.abstractIn 2014, Western Africa experienced an unanticipated explosion of Ebola virus infections. What distinguishes fatal from non-fatal outcomes remains largely unknown, yet is key to optimising personalised treatment strategies. We used transcriptome data for peripheral blood taken from infected and convalescent recovering patients to identify early stage host factors that are associated with acute illness and those that differentiate patient survival from fatality.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.rightsArchived with thanks to Genome Biologyen
dc.titleTranscriptomic Signatures Differentiate Survival from Fatal Outcomes in Humans Infected with Ebola Virusen
dc.identifier.journalGenome Biologyen

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