Adapting to the Global Shortage of Cholera Vaccines: Targeted Single Dose Cholera Vaccine in Response to an Outbreak in South Sudan

Hdl Handle:
http://hdl.handle.net/10144/618770
Title:
Adapting to the Global Shortage of Cholera Vaccines: Targeted Single Dose Cholera Vaccine in Response to an Outbreak in South Sudan
Authors:
Parker, LA; Rumunu, J; Jamet, C; Kenyi, Y; Lino, RL; Wamala, JF; Mpairwe, AM; Ciglenecki, I; Luquero, FJ; Azman, AS; Cabrol, JC
Journal:
The Lancet. Infectious Diseases
Abstract:
Shortages of vaccines for epidemic diseases, such as cholera, meningitis, and yellow fever, have become common over the past decade, hampering efforts to control outbreaks through mass reactive vaccination campaigns. Additionally, various epidemiological, political, and logistical challenges, which are poorly documented in the literature, often lead to delays in reactive campaigns, ultimately reducing the effect of vaccination. In June 2015, a cholera outbreak occurred in Juba, South Sudan, and because of the global shortage of oral cholera vaccine, authorities were unable to secure sufficient doses to vaccinate the entire at-risk population-approximately 1 million people. In this Personal View, we document the first public health use of a reduced, single-dose regimen of oral cholera vaccine, and show the details of the decision-making process and timeline. We also make recommendations to help improve reactive vaccination campaigns against cholera, and discuss the importance of new and flexible context-specific dose regimens and vaccination strategies.
Publisher:
Elsevier
Issue Date:
18-Jan-2017
URI:
http://hdl.handle.net/10144/618770
DOI:
10.1016/S1473-3099(16)30472-8
PubMed ID:
28109819
Submitted date:
2017-01-25
Language:
en
ISSN:
1474-4457
Appears in Collections:
Vaccination

Full metadata record

DC FieldValue Language
dc.contributor.authorParker, LAen
dc.contributor.authorRumunu, Jen
dc.contributor.authorJamet, Cen
dc.contributor.authorKenyi, Yen
dc.contributor.authorLino, RLen
dc.contributor.authorWamala, JFen
dc.contributor.authorMpairwe, AMen
dc.contributor.authorCiglenecki, Ien
dc.contributor.authorLuquero, FJen
dc.contributor.authorAzman, ASen
dc.contributor.authorCabrol, JCen
dc.date.accessioned2017-01-25T16:12:07Z-
dc.date.available2017-01-25T16:12:07Z-
dc.date.issued2017-01-18-
dc.date.submitted2017-01-25-
dc.identifier.citationAdapting to the Global Shortage of Cholera Vaccines: Targeted Single Dose Cholera Vaccine in Response to an Outbreak in South Sudan. 2017 Lancet Infect Disen
dc.identifier.issn1474-4457-
dc.identifier.pmid28109819-
dc.identifier.doi10.1016/S1473-3099(16)30472-8-
dc.identifier.urihttp://hdl.handle.net/10144/618770-
dc.description.abstractShortages of vaccines for epidemic diseases, such as cholera, meningitis, and yellow fever, have become common over the past decade, hampering efforts to control outbreaks through mass reactive vaccination campaigns. Additionally, various epidemiological, political, and logistical challenges, which are poorly documented in the literature, often lead to delays in reactive campaigns, ultimately reducing the effect of vaccination. In June 2015, a cholera outbreak occurred in Juba, South Sudan, and because of the global shortage of oral cholera vaccine, authorities were unable to secure sufficient doses to vaccinate the entire at-risk population-approximately 1 million people. In this Personal View, we document the first public health use of a reduced, single-dose regimen of oral cholera vaccine, and show the details of the decision-making process and timeline. We also make recommendations to help improve reactive vaccination campaigns against cholera, and discuss the importance of new and flexible context-specific dose regimens and vaccination strategies.en
dc.language.isoenen
dc.publisherElsevieren
dc.rightsArchived with thanks to The Lancet. Infectious Diseasesen
dc.titleAdapting to the Global Shortage of Cholera Vaccines: Targeted Single Dose Cholera Vaccine in Response to an Outbreak in South Sudanen
dc.identifier.journalThe Lancet. Infectious Diseasesen

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