A Worldwide Map of Plasmodium Falciparum K13-Propeller Polymorphisms

Hdl Handle:
http://hdl.handle.net/10144/618776
Title:
A Worldwide Map of Plasmodium Falciparum K13-Propeller Polymorphisms
Authors:
Ménard, D; Khim, N; Beghain, J; Adegnika, AA; Shafiul-Alam, M; Amodu, O; Rahim-Awab, G; Barnadas, C; Berry, A; Boum, Y; Bustos, MD; Cao, J; Chen, JH; Collet, L; Cui, L; Thakur, GD; Dieye, A; Djallé, D; Dorkenoo, MA; Eboumbou-Moukoko, CE; Espino, FEJ; Fandeur, T; Ferreira-da-Cruz, MF; Fola, AA; Fuehrer, HP; Hassan, AM; Herrera, S; Hongvanthong, B; Houzé, S; Ibrahim, ML; Jahirul-Karim, M; Jiang, L; Kano, S; Ali-Khan, W; Khanthavong, M; Kremsner, PG; Lacerda, M; Leang, R; Leelawong, M; Li, M; Lin, K; Mazarati, JB; Ménard, S; Morlais, I; Muhindo-Mavoko, H; Musset, L; Na-Bangchang, K; Nambozi, M; Niaré, K; Noedl, H; Ouédraogo, JB; Pillai, DR; Pradines, B; Quang-Phuc, B; Ramharter, M; Randrianarivelojosia, M; Sattabongkot, J; Sheikh-Omar, A; Silué, KD; Sirima, SB; Sutherland, C; Syafruddin, D; Tahar, R; Tang, LH; Touré, OA; Tshibangu-wa-Tshibangu, P; Vigan-Womas, I; Warsame, M; Wini, L; Zakeri, S; Kim, S; Eam, R; Berne, L; Khean, C; Chy, S; Ken, M; Loch, K; Canier, L; Duru, V; Legrand, E; Barale, JC; Stokes, B; Straimer, J; Witkowski, B; Fidock, DA; Rogier, C; Ringwald, P; Ariey, F; Mercereau-Puijalon, O
Journal:
The New England Journal of Medicine
Abstract:
Recent gains in reducing the global burden of malaria are threatened by the emergence of Plasmodium falciparum resistance to artemisinins. The discovery that mutations in portions of a P. falciparum gene encoding kelch (K13)-propeller domains are the major determinant of resistance has provided opportunities for monitoring such resistance on a global scale.
Publisher:
Massachusetts Medical Society
Issue Date:
23-Jun-2016
URI:
http://hdl.handle.net/10144/618776
DOI:
10.1056/NEJMoa1513137
PubMed ID:
27332904
Submitted date:
2017-01-19
Language:
en
ISSN:
1533-4406
Appears in Collections:
Malaria

Full metadata record

DC FieldValue Language
dc.contributor.authorMénard, Den
dc.contributor.authorKhim, Nen
dc.contributor.authorBeghain, Jen
dc.contributor.authorAdegnika, AAen
dc.contributor.authorShafiul-Alam, Men
dc.contributor.authorAmodu, Oen
dc.contributor.authorRahim-Awab, Gen
dc.contributor.authorBarnadas, Cen
dc.contributor.authorBerry, Aen
dc.contributor.authorBoum, Yen
dc.contributor.authorBustos, MDen
dc.contributor.authorCao, Jen
dc.contributor.authorChen, JHen
dc.contributor.authorCollet, Len
dc.contributor.authorCui, Len
dc.contributor.authorThakur, GDen
dc.contributor.authorDieye, Aen
dc.contributor.authorDjallé, Den
dc.contributor.authorDorkenoo, MAen
dc.contributor.authorEboumbou-Moukoko, CEen
dc.contributor.authorEspino, FEJen
dc.contributor.authorFandeur, Ten
dc.contributor.authorFerreira-da-Cruz, MFen
dc.contributor.authorFola, AAen
dc.contributor.authorFuehrer, HPen
dc.contributor.authorHassan, AMen
dc.contributor.authorHerrera, Sen
dc.contributor.authorHongvanthong, Ben
dc.contributor.authorHouzé, Sen
dc.contributor.authorIbrahim, MLen
dc.contributor.authorJahirul-Karim, Men
dc.contributor.authorJiang, Len
dc.contributor.authorKano, Sen
dc.contributor.authorAli-Khan, Wen
dc.contributor.authorKhanthavong, Men
dc.contributor.authorKremsner, PGen
dc.contributor.authorLacerda, Men
dc.contributor.authorLeang, Ren
dc.contributor.authorLeelawong, Men
dc.contributor.authorLi, Men
dc.contributor.authorLin, Ken
dc.contributor.authorMazarati, JBen
dc.contributor.authorMénard, Sen
dc.contributor.authorMorlais, Ien
dc.contributor.authorMuhindo-Mavoko, Hen
dc.contributor.authorMusset, Len
dc.contributor.authorNa-Bangchang, Ken
dc.contributor.authorNambozi, Men
dc.contributor.authorNiaré, Ken
dc.contributor.authorNoedl, Hen
dc.contributor.authorOuédraogo, JBen
dc.contributor.authorPillai, DRen
dc.contributor.authorPradines, Ben
dc.contributor.authorQuang-Phuc, Ben
dc.contributor.authorRamharter, Men
dc.contributor.authorRandrianarivelojosia, Men
dc.contributor.authorSattabongkot, Jen
dc.contributor.authorSheikh-Omar, Aen
dc.contributor.authorSilué, KDen
dc.contributor.authorSirima, SBen
dc.contributor.authorSutherland, Cen
dc.contributor.authorSyafruddin, Den
dc.contributor.authorTahar, Ren
dc.contributor.authorTang, LHen
dc.contributor.authorTouré, OAen
dc.contributor.authorTshibangu-wa-Tshibangu, Pen
dc.contributor.authorVigan-Womas, Ien
dc.contributor.authorWarsame, Men
dc.contributor.authorWini, Len
dc.contributor.authorZakeri, Sen
dc.contributor.authorKim, Sen
dc.contributor.authorEam, Ren
dc.contributor.authorBerne, Len
dc.contributor.authorKhean, Cen
dc.contributor.authorChy, Sen
dc.contributor.authorKen, Men
dc.contributor.authorLoch, Ken
dc.contributor.authorCanier, Len
dc.contributor.authorDuru, Ven
dc.contributor.authorLegrand, Een
dc.contributor.authorBarale, JCen
dc.contributor.authorStokes, Ben
dc.contributor.authorStraimer, Jen
dc.contributor.authorWitkowski, Ben
dc.contributor.authorFidock, DAen
dc.contributor.authorRogier, Cen
dc.contributor.authorRingwald, Pen
dc.contributor.authorAriey, Fen
dc.contributor.authorMercereau-Puijalon, Oen
dc.date.accessioned2017-01-25T16:24:51Z-
dc.date.available2017-01-25T16:24:51Z-
dc.date.issued2016-06-23-
dc.date.submitted2017-01-19-
dc.identifier.citationA Worldwide Map of Plasmodium Falciparum K13-Propeller Polymorphisms. 2016, 374 (25):2453-64 N. Engl. J. Med.en
dc.identifier.issn1533-4406-
dc.identifier.pmid27332904-
dc.identifier.doi10.1056/NEJMoa1513137-
dc.identifier.urihttp://hdl.handle.net/10144/618776-
dc.description.abstractRecent gains in reducing the global burden of malaria are threatened by the emergence of Plasmodium falciparum resistance to artemisinins. The discovery that mutations in portions of a P. falciparum gene encoding kelch (K13)-propeller domains are the major determinant of resistance has provided opportunities for monitoring such resistance on a global scale.en
dc.language.isoenen
dc.publisherMassachusetts Medical Societyen
dc.rightsArchived with thanks to The New England Journal of Medicineen
dc.subject.meshAlgorithmsen
dc.subject.meshArtemisininsen
dc.subject.meshAsia, Southeasternen
dc.subject.meshChinaen
dc.subject.meshDrug Resistanceen
dc.subject.meshEndemic Diseasesen
dc.subject.meshGenotypeen
dc.subject.meshHumansen
dc.subject.meshLactonesen
dc.subject.meshMalaria, Falciparumen
dc.subject.meshMutationen
dc.subject.meshPlasmodium falciparumen
dc.subject.meshPolymorphism, Geneticen
dc.subject.meshProtozoan Proteinsen
dc.subject.meshSequence Analysis, DNAen
dc.titleA Worldwide Map of Plasmodium Falciparum K13-Propeller Polymorphismsen
dc.identifier.journalThe New England Journal of Medicineen

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