Clinical Chemistry of Patients With Ebola in Monrovia, Liberia

Hdl Handle:
http://hdl.handle.net/10144/618821
Title:
Clinical Chemistry of Patients With Ebola in Monrovia, Liberia
Authors:
de Wit, E; Kramer, S; Prescott, J; Rosenke, K; Falzarano, D; Marzi, A; Fischer, RJ; Safronetz, D; Hoenen, T; Groseth, A; van Doremalen, N; Bushmaker, T; McNally, KL; Feldmann, F; Williamson, BN; Best, SM; Ebihara, H; Damiani, IA; Adamson, B; Zoon, KC; Nyenswah, TG; Bolay, FK; Massaquoi, M; Sprecher, A; Feldmann, H; Munster, VJ
Journal:
Journal of Infectious Diseases
Abstract:
The development of point-of-care clinical chemistry analyzers has enabled the implementation of these ancillary tests in field laboratories in resource-limited outbreak areas. The Eternal Love Winning Africa (ELWA) outbreak diagnostic laboratory, established in Monrovia, Liberia, to provide Ebola virus and Plasmodium spp. diagnostics during the Ebola epidemic, implemented clinical chemistry analyzers in December 2014. Clinical chemistry testing was performed for 68 patients in triage, including 12 patients infected with Ebola virus and 18 infected with Plasmodium spp. The main distinguishing feature in clinical chemistry of Ebola virus-infected patients was the elevation in alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and γ-glutamyltransferase levels and the decrease in calcium. The implementation of clinical chemistry is probably most helpful when the medical supportive care implemented at the Ebola treatment unit allows for correction of biochemistry derangements and on-site clinical chemistry analyzers can be used to monitor electrolyte balance.
Publisher:
Oxford University Press
Issue Date:
28-Jul-2016
URI:
http://hdl.handle.net/10144/618821
DOI:
10.1093/infdis/jiw187
PubMed ID:
27471319
Submitted date:
2016-08-03
Language:
en
ISSN:
1537-6613
Appears in Collections:
Other Diseases

Full metadata record

DC FieldValue Language
dc.contributor.authorde Wit, Een
dc.contributor.authorKramer, Sen
dc.contributor.authorPrescott, Jen
dc.contributor.authorRosenke, Ken
dc.contributor.authorFalzarano, Den
dc.contributor.authorMarzi, Aen
dc.contributor.authorFischer, RJen
dc.contributor.authorSafronetz, Den
dc.contributor.authorHoenen, Ten
dc.contributor.authorGroseth, Aen
dc.contributor.authorvan Doremalen, Nen
dc.contributor.authorBushmaker, Ten
dc.contributor.authorMcNally, KLen
dc.contributor.authorFeldmann, Fen
dc.contributor.authorWilliamson, BNen
dc.contributor.authorBest, SMen
dc.contributor.authorEbihara, Hen
dc.contributor.authorDamiani, IAen
dc.contributor.authorAdamson, Ben
dc.contributor.authorZoon, KCen
dc.contributor.authorNyenswah, TGen
dc.contributor.authorBolay, FKen
dc.contributor.authorMassaquoi, Men
dc.contributor.authorSprecher, Aen
dc.contributor.authorFeldmann, Hen
dc.contributor.authorMunster, VJen
dc.date.accessioned2017-02-28T22:30:36Z-
dc.date.available2017-02-28T22:30:36Z-
dc.date.issued2016-07-28-
dc.date.submitted2016-08-03-
dc.identifier.citationClinical Chemistry of Patients With Ebola in Monrovia, Liberia. 2016: J. Infect. Dis.en
dc.identifier.issn1537-6613-
dc.identifier.pmid27471319-
dc.identifier.doi10.1093/infdis/jiw187-
dc.identifier.urihttp://hdl.handle.net/10144/618821-
dc.description.abstractThe development of point-of-care clinical chemistry analyzers has enabled the implementation of these ancillary tests in field laboratories in resource-limited outbreak areas. The Eternal Love Winning Africa (ELWA) outbreak diagnostic laboratory, established in Monrovia, Liberia, to provide Ebola virus and Plasmodium spp. diagnostics during the Ebola epidemic, implemented clinical chemistry analyzers in December 2014. Clinical chemistry testing was performed for 68 patients in triage, including 12 patients infected with Ebola virus and 18 infected with Plasmodium spp. The main distinguishing feature in clinical chemistry of Ebola virus-infected patients was the elevation in alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and γ-glutamyltransferase levels and the decrease in calcium. The implementation of clinical chemistry is probably most helpful when the medical supportive care implemented at the Ebola treatment unit allows for correction of biochemistry derangements and on-site clinical chemistry analyzers can be used to monitor electrolyte balance.en
dc.languageENG-
dc.language.isoenen
dc.publisherOxford University Pressen
dc.rightsPublished by Infectious Diseases Society of America Archived on this site with permission and copyright 200X by the Infectious Diseases Society of America, [url] and Oxford University Pressen
dc.titleClinical Chemistry of Patients With Ebola in Monrovia, Liberiaen
dc.identifier.journalJournal of Infectious Diseasesen

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