Ebola Virus Disease in Pregnancy: Clinical, Histopathologic and Immunohistochemical Findings

Hdl Handle:
http://hdl.handle.net/10144/618827
Title:
Ebola Virus Disease in Pregnancy: Clinical, Histopathologic and Immunohistochemical Findings
Authors:
Muehlenbachs, A; de la Rosa Vázquez, O; Bausch, DG; Schafer, IJ; Paddock, CD; Nyakio, JP; Lame, P; Bergeron, E; McCollum, AM; Goldsmith, CS; Bollweg, BC; Prieto, MA; Lushima, RS; Ilunga, BK; Nichol, ST; Shieh, WJ; Ströher, U; Rollin, PE; Zaki, SR
Journal:
Journal of Infectious Diseases
Abstract:
Here we describe clinicopathologic features of EVD in pregnancy. One woman infected with Sudan virus in Gulu, Uganda in 2000 had a stillbirth and survived, and another woman with Bundibugyo virus had a livebirth with maternal and infant death in Isiro, the Democratic Republic of the Congo in 2012. Ebolavirus antigen was seen in the syncytiotrophoblast and placental maternal mononuclear cells by immunohistochemistry, and no antigen was seen in fetal placental stromal cells or fetal organs. In the Gulu case, ebolavirus antigen localized to malaria pigment-laden macrophages. These data suggest trophoblast infection may be a mechanism of transplacental ebolavirus transmission.
Publisher:
Oxford University Press We regret that this article is behind a paywall.
Issue Date:
25-May-2016
URI:
http://hdl.handle.net/10144/618827
DOI:
10.1093/infdis/jiw206
PubMed ID:
27226206
Submitted date:
2016-05-31
Language:
en
ISSN:
1537-6613
Appears in Collections:
Other Diseases

Full metadata record

DC FieldValue Language
dc.contributor.authorMuehlenbachs, Aen
dc.contributor.authorde la Rosa Vázquez, Oen
dc.contributor.authorBausch, DGen
dc.contributor.authorSchafer, IJen
dc.contributor.authorPaddock, CDen
dc.contributor.authorNyakio, JPen
dc.contributor.authorLame, Pen
dc.contributor.authorBergeron, Een
dc.contributor.authorMcCollum, AMen
dc.contributor.authorGoldsmith, CSen
dc.contributor.authorBollweg, BCen
dc.contributor.authorPrieto, MAen
dc.contributor.authorLushima, RSen
dc.contributor.authorIlunga, BKen
dc.contributor.authorNichol, STen
dc.contributor.authorShieh, WJen
dc.contributor.authorStröher, Uen
dc.contributor.authorRollin, PEen
dc.contributor.authorZaki, SRen
dc.date.accessioned2017-02-28T22:46:51Z-
dc.date.available2017-02-28T22:46:51Z-
dc.date.issued2016-05-25en
dc.date.submitted2016-05-31en
dc.identifier.citationEbola virus disease in pregnancy: clinical, histopathologic and immunohistochemical findings. 2016: J. Infect. Dis.en
dc.identifier.issn1537-6613en
dc.identifier.pmid27226206en
dc.identifier.doi10.1093/infdis/jiw206en
dc.identifier.urihttp://hdl.handle.net/10144/618827-
dc.description.abstractHere we describe clinicopathologic features of EVD in pregnancy. One woman infected with Sudan virus in Gulu, Uganda in 2000 had a stillbirth and survived, and another woman with Bundibugyo virus had a livebirth with maternal and infant death in Isiro, the Democratic Republic of the Congo in 2012. Ebolavirus antigen was seen in the syncytiotrophoblast and placental maternal mononuclear cells by immunohistochemistry, and no antigen was seen in fetal placental stromal cells or fetal organs. In the Gulu case, ebolavirus antigen localized to malaria pigment-laden macrophages. These data suggest trophoblast infection may be a mechanism of transplacental ebolavirus transmission.en
dc.languageENGen
dc.language.isoenen
dc.publisherOxford University Press We regret that this article is behind a paywall.en
dc.titleEbola Virus Disease in Pregnancy: Clinical, Histopathologic and Immunohistochemical Findingsen
dc.identifier.journalJournal of Infectious Diseasesen

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