Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage

Hdl Handle:
http://hdl.handle.net/10144/618867
Title:
Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage
Authors:
Merker, Matthias; Blin, Camille; Mona, Stefano; Duforet-Frebourg, Nicolas; Lecher, Sophie; Willery, Eve; Blum, Michael; Rüsch-Gerdes, Sabine; Mokrousov, Igor; Aleksic, Eman; Allix-Béguec, Caroline; Antierens, Annick; Augustynowicz-Kopeć, Ewa; Ballif, Marie; Barletta, Francesca; Beck, Hans Peter; Barry, Clifton E; Bonnet, Maryline; Borroni, Emanuele; Campos-Herrero, Isolina; Cirillo, Daniela; Cox, Helen; Crowe, Suzanne; Crudu, Valeriu; Diel, Roland; Drobniewski, Francis; Fauville-Dufaux, Maryse; Gagneux, Sébastien; Ghebremichael, Solomon; Hanekom, Madeleine; Hoffner, Sven; Jiao, Wei-Wei; Kalon, Stobdan; Kohl, Thomas A; Kontsevaya, Irina; Lillebæk, Troels; Maeda, Shinji; Nikolayevskyy, Vladyslav; Rasmussen, Michael; Rastogi, Nalin; Samper, Sofia; Sanchez-Padilla, Elisabeth; Savic, Branislava; Shamputa, Isdore Chola; Shen, Adong; Sng, Li-Hwei; Stakenas, Petras; Toit, Kadri; Varaine, Francis; Vukovic, Dragana; Wahl, Céline; Warren, Robin; Supply, Philip; Niemann, Stefan; Wirth, Thierry
Journal:
Nature Genetics
Abstract:
Mycobacterium tuberculosis strains of the Beijing lineage are globally distributed and are associated with the massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia. Here we reconstructed the biogeographical structure and evolutionary history of this lineage by genetic analysis of 4,987 isolates from 99 countries and whole-genome sequencing of 110 representative isolates. We show that this lineage initially originated in the Far East, from where it radiated worldwide in several waves. We detected successive increases in population size for this pathogen over the last 200 years, practically coinciding with the Industrial Revolution, the First World War and HIV epidemics. Two MDR clones of this lineage started to spread throughout central Asia and Russia concomitantly with the collapse of the public health system in the former Soviet Union. Mutations identified in genes putatively under positive selection and associated with virulence might have favored the expansion of the most successful branches of the lineage.
Publisher:
Nature Publishing Group - We regret that this article is behind a paywall.
Issue Date:
19-Jan-2015
URI:
http://hdl.handle.net/10144/618867
DOI:
10.1038/ng.3195
PubMed ID:
25599400
Language:
en
ISSN:
1546-1718
Appears in Collections:
TB

Full metadata record

DC FieldValue Language
dc.contributor.authorMerker, Matthiasen
dc.contributor.authorBlin, Camilleen
dc.contributor.authorMona, Stefanoen
dc.contributor.authorDuforet-Frebourg, Nicolasen
dc.contributor.authorLecher, Sophieen
dc.contributor.authorWillery, Eveen
dc.contributor.authorBlum, Michaelen
dc.contributor.authorRüsch-Gerdes, Sabineen
dc.contributor.authorMokrousov, Igoren
dc.contributor.authorAleksic, Emanen
dc.contributor.authorAllix-Béguec, Carolineen
dc.contributor.authorAntierens, Annicken
dc.contributor.authorAugustynowicz-Kopeć, Ewaen
dc.contributor.authorBallif, Marieen
dc.contributor.authorBarletta, Francescaen
dc.contributor.authorBeck, Hans Peteren
dc.contributor.authorBarry, Clifton Een
dc.contributor.authorBonnet, Marylineen
dc.contributor.authorBorroni, Emanueleen
dc.contributor.authorCampos-Herrero, Isolinaen
dc.contributor.authorCirillo, Danielaen
dc.contributor.authorCox, Helenen
dc.contributor.authorCrowe, Suzanneen
dc.contributor.authorCrudu, Valeriuen
dc.contributor.authorDiel, Rolanden
dc.contributor.authorDrobniewski, Francisen
dc.contributor.authorFauville-Dufaux, Maryseen
dc.contributor.authorGagneux, Sébastienen
dc.contributor.authorGhebremichael, Solomonen
dc.contributor.authorHanekom, Madeleineen
dc.contributor.authorHoffner, Svenen
dc.contributor.authorJiao, Wei-Weien
dc.contributor.authorKalon, Stobdanen
dc.contributor.authorKohl, Thomas Aen
dc.contributor.authorKontsevaya, Irinaen
dc.contributor.authorLillebæk, Troelsen
dc.contributor.authorMaeda, Shinjien
dc.contributor.authorNikolayevskyy, Vladyslaven
dc.contributor.authorRasmussen, Michaelen
dc.contributor.authorRastogi, Nalinen
dc.contributor.authorSamper, Sofiaen
dc.contributor.authorSanchez-Padilla, Elisabethen
dc.contributor.authorSavic, Branislavaen
dc.contributor.authorShamputa, Isdore Cholaen
dc.contributor.authorShen, Adongen
dc.contributor.authorSng, Li-Hweien
dc.contributor.authorStakenas, Petrasen
dc.contributor.authorToit, Kadrien
dc.contributor.authorVaraine, Francisen
dc.contributor.authorVukovic, Draganaen
dc.contributor.authorWahl, Célineen
dc.contributor.authorWarren, Robinen
dc.contributor.authorSupply, Philipen
dc.contributor.authorNiemann, Stefanen
dc.contributor.authorWirth, Thierryen
dc.date.accessioned2017-03-21T16:45:20Z-
dc.date.available2017-03-21T16:45:20Z-
dc.date.issued2015-01-19-
dc.identifier.citationEvolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage. 2015: Nat. Genet.en
dc.identifier.issn1546-1718-
dc.identifier.pmid25599400-
dc.identifier.doi10.1038/ng.3195-
dc.identifier.urihttp://hdl.handle.net/10144/618867-
dc.description.abstractMycobacterium tuberculosis strains of the Beijing lineage are globally distributed and are associated with the massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia. Here we reconstructed the biogeographical structure and evolutionary history of this lineage by genetic analysis of 4,987 isolates from 99 countries and whole-genome sequencing of 110 representative isolates. We show that this lineage initially originated in the Far East, from where it radiated worldwide in several waves. We detected successive increases in population size for this pathogen over the last 200 years, practically coinciding with the Industrial Revolution, the First World War and HIV epidemics. Two MDR clones of this lineage started to spread throughout central Asia and Russia concomitantly with the collapse of the public health system in the former Soviet Union. Mutations identified in genes putatively under positive selection and associated with virulence might have favored the expansion of the most successful branches of the lineage.en
dc.languageENG-
dc.language.isoenen
dc.publisherNature Publishing Group - We regret that this article is behind a paywall.en
dc.titleEvolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineageen
dc.identifier.journalNature Geneticsen

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