Using Simulation to Aid Trial Design: Ring-Vaccination Trials.

Hdl Handle:
http://hdl.handle.net/10144/618875
Title:
Using Simulation to Aid Trial Design: Ring-Vaccination Trials.
Authors:
Hitchings, MD; Grais, RF; Lipsitch, M
Journal:
PLoS Neglected Tropical Diseases
Abstract:
The 2014-6 West African Ebola epidemic highlights the need for rigorous, rapid clinical trial methods for vaccines. A challenge for trial design is making sample size calculations based on incidence within the trial, total vaccine effect, and intracluster correlation, when these parameters are uncertain in the presence of indirect effects of vaccination.
Publisher:
Public Library of Science
Issue Date:
22-Mar-2017
URI:
http://hdl.handle.net/10144/618875
DOI:
10.1371/journal.pntd.0005470
PubMed ID:
28328984
Submitted date:
2017-03-29
Language:
en
ISSN:
1935-2735
Appears in Collections:
Vaccination

Full metadata record

DC FieldValue Language
dc.contributor.authorHitchings, MDen
dc.contributor.authorGrais, RFen
dc.contributor.authorLipsitch, Men
dc.date.accessioned2017-03-30T13:32:21Z-
dc.date.available2017-03-30T13:32:21Z-
dc.date.issued2017-03-22-
dc.date.submitted2017-03-29-
dc.identifier.citationUsing Simulation to Aid Trial Design: Ring-Vaccination Trials. 2017, 11 (3):e0005470 PLoS Negl Trop Disen
dc.identifier.issn1935-2735-
dc.identifier.pmid28328984-
dc.identifier.doi10.1371/journal.pntd.0005470-
dc.identifier.urihttp://hdl.handle.net/10144/618875-
dc.description.abstractThe 2014-6 West African Ebola epidemic highlights the need for rigorous, rapid clinical trial methods for vaccines. A challenge for trial design is making sample size calculations based on incidence within the trial, total vaccine effect, and intracluster correlation, when these parameters are uncertain in the presence of indirect effects of vaccination.en
dc.language.isoenen
dc.publisherPublic Library of Scienceen
dc.rightsArchived with thanks to PLoS Neglected Tropical Diseasesen
dc.titleUsing Simulation to Aid Trial Design: Ring-Vaccination Trials.en
dc.identifier.journalPLoS Neglected Tropical Diseasesen

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