Mycobacterium Tuberculosis Lineage 4 Comprises Globally Distributed and Geographically Restricted Sublineages

Hdl Handle:
http://hdl.handle.net/10144/618917
Title:
Mycobacterium Tuberculosis Lineage 4 Comprises Globally Distributed and Geographically Restricted Sublineages
Authors:
Stucki, D; Brites, D; Jeljeli, L; Coscolla, M; Liu, Q; Trauner, A; Fenner, L; Rutaihwa, L; Borrell, S; Luo, T; Gao, Q; Kato-Maeda, M; Ballif, M; Egger, M; Macedo, R; Mardassi, H; Moreno, M; Vilanova, GT; Fyfe, J; Globan, M; Thomas, J; Jamieson, F; Guthrie, JL; Asante-Poku, A; Yeboah-Manu, D; Wampande, E; Ssengooba, W; Joloba, M; Boom, WH; Basu, I; Bower, J; Saraiva, M; Vasconcellos, SEG; Suffys, P; Koch, A; Wilkinson, R; Gail-Bekker, L; Malla, B; Ley, SD; Beck, HP; de Jong, Bouke C; Toit, K; Sanchez-Padilla, E; Bonnet, M; Gil-Brusola, A; Frank, M; Penlap Beng, VN; Eisenach, K; Alani, I; Ndung'u, PW; Revathi, G; Gehre, F; Akter, S; Ntoumi, F; Stewart-Isherwood, L; Ntinginya, NE; Rachow, A; Hoelscher, M; Cirillo, DM; Skenders, G; Hoffner, S; Bakonyte, D; Stakenas, P; Diel, R; Crudu, V; Moldovan, O; Al-Hajoj, S; Otero, L; Barletta, F; Carter, EJ; Diero, L; Supply, P; Comas, I; Niemann, S; Gagneux, S
Journal:
Nature Genetics
Abstract:
Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration.
Publisher:
Nature Publishing Group
Issue Date:
1-Dec-2016
URI:
http://hdl.handle.net/10144/618917
DOI:
10.1038/ng.3704
PubMed ID:
27798628
Submitted date:
2017-05-24
Language:
en
ISSN:
1546-1718
Appears in Collections:
TB

Full metadata record

DC FieldValue Language
dc.contributor.authorStucki, Den
dc.contributor.authorBrites, Den
dc.contributor.authorJeljeli, Len
dc.contributor.authorCoscolla, Men
dc.contributor.authorLiu, Qen
dc.contributor.authorTrauner, Aen
dc.contributor.authorFenner, Len
dc.contributor.authorRutaihwa, Len
dc.contributor.authorBorrell, Sen
dc.contributor.authorLuo, Ten
dc.contributor.authorGao, Qen
dc.contributor.authorKato-Maeda, Men
dc.contributor.authorBallif, Men
dc.contributor.authorEgger, Men
dc.contributor.authorMacedo, Ren
dc.contributor.authorMardassi, Hen
dc.contributor.authorMoreno, Men
dc.contributor.authorVilanova, GTen
dc.contributor.authorFyfe, Jen
dc.contributor.authorGloban, Men
dc.contributor.authorThomas, Jen
dc.contributor.authorJamieson, Fen
dc.contributor.authorGuthrie, JLen
dc.contributor.authorAsante-Poku, Aen
dc.contributor.authorYeboah-Manu, Den
dc.contributor.authorWampande, Een
dc.contributor.authorSsengooba, Wen
dc.contributor.authorJoloba, Men
dc.contributor.authorBoom, WHen
dc.contributor.authorBasu, Ien
dc.contributor.authorBower, Jen
dc.contributor.authorSaraiva, Men
dc.contributor.authorVasconcellos, SEGen
dc.contributor.authorSuffys, Pen
dc.contributor.authorKoch, Aen
dc.contributor.authorWilkinson, Ren
dc.contributor.authorGail-Bekker, Len
dc.contributor.authorMalla, Ben
dc.contributor.authorLey, SDen
dc.contributor.authorBeck, HPen
dc.contributor.authorde Jong, Bouke Cen
dc.contributor.authorToit, Ken
dc.contributor.authorSanchez-Padilla, Een
dc.contributor.authorBonnet, Men
dc.contributor.authorGil-Brusola, Aen
dc.contributor.authorFrank, Men
dc.contributor.authorPenlap Beng, VNen
dc.contributor.authorEisenach, Ken
dc.contributor.authorAlani, Ien
dc.contributor.authorNdung'u, PWen
dc.contributor.authorRevathi, Gen
dc.contributor.authorGehre, Fen
dc.contributor.authorAkter, Sen
dc.contributor.authorNtoumi, Fen
dc.contributor.authorStewart-Isherwood, Len
dc.contributor.authorNtinginya, NEen
dc.contributor.authorRachow, Aen
dc.contributor.authorHoelscher, Men
dc.contributor.authorCirillo, DMen
dc.contributor.authorSkenders, Gen
dc.contributor.authorHoffner, Sen
dc.contributor.authorBakonyte, Den
dc.contributor.authorStakenas, Pen
dc.contributor.authorDiel, Ren
dc.contributor.authorCrudu, Ven
dc.contributor.authorMoldovan, Oen
dc.contributor.authorAl-Hajoj, Sen
dc.contributor.authorOtero, Len
dc.contributor.authorBarletta, Fen
dc.contributor.authorCarter, EJen
dc.contributor.authorDiero, Len
dc.contributor.authorSupply, Pen
dc.contributor.authorComas, Ien
dc.contributor.authorNiemann, Sen
dc.contributor.authorGagneux, Sen
dc.date.accessioned2017-05-29T14:04:14Z-
dc.date.available2017-05-29T14:04:14Z-
dc.date.issued2016-12-01-
dc.date.submitted2017-05-24-
dc.identifier.citationMycobacterium Tuberculosis Lineage 4 Comprises Globally Distributed and Geographically Restricted Sublineages. 2016, 48 (12):1535-1543 Nat. Genet.en
dc.identifier.issn1546-1718-
dc.identifier.pmid27798628-
dc.identifier.doi10.1038/ng.3704-
dc.identifier.urihttp://hdl.handle.net/10144/618917-
dc.description.abstractGeneralist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration.en
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.rightsArchived with thanks to Nature Geneticsen
dc.titleMycobacterium Tuberculosis Lineage 4 Comprises Globally Distributed and Geographically Restricted Sublineagesen
dc.identifier.journalNature Geneticsen

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