Deuterium Dilution Technique for Body Composition Assessment: Resolving Methodological Issues in Children with Moderate Acute Malnutrition

Hdl Handle:
http://hdl.handle.net/10144/619013
Title:
Deuterium Dilution Technique for Body Composition Assessment: Resolving Methodological Issues in Children with Moderate Acute Malnutrition
Authors:
Fabiansen, C; Yaméogo, CW; Devi, S; Friis, H; Kurpad, A; Wells, JC
Journal:
Isotopes in Environmental and Health Studies
Abstract:
Childhood malnutrition is highly prevalent and associated with high mortality risk. In observational and interventional studies among malnourished children, body composition is increasingly recognised as a key outcome. The deuterium dilution technique has generated high-quality data on body composition in studies of infants and young children in several settings, but its feasibility and accuracy in children suffering from moderate acute malnutrition requires further study. Prior to a large nutritional intervention trial among children with moderate acute malnutrition, we conducted pilot work to develop and adapt the deuterium dilution technique. We refined procedures for administration of isotope doses and collection of saliva. Furthermore, we established that equilibration time in local context is 3 h. These findings and the resulting standard operating procedures are important to improve data quality when using the deuterium dilution technique in malnutrition studies in field conditions, and may encourage a wider use of isotope techniques.
Publisher:
Taylor and Francis
Issue Date:
3-Mar-2017
URI:
http://hdl.handle.net/10144/619013
DOI:
10.1080/10256016.2017.1295043
PubMed ID:
28276731
Additional Links:
http://www.tandfonline.com/doi/abs/10.1080/10256016.2017.1295043
Submitted date:
2017-03-15
Language:
en
Description:
Abstract available only. Full article is not Open Access. We regret that this article is behind a paywall.
ISSN:
1477-2639
Appears in Collections:
Paediatrics

Full metadata record

DC FieldValue Language
dc.contributor.authorFabiansen, Cen
dc.contributor.authorYaméogo, CWen
dc.contributor.authorDevi, Sen
dc.contributor.authorFriis, Hen
dc.contributor.authorKurpad, Aen
dc.contributor.authorWells, JCen
dc.date.accessioned2017-09-07T13:52:46Z-
dc.date.available2017-09-07T13:52:46Z-
dc.date.issued2017-03-03-
dc.date.submitted2017-03-15-
dc.identifier.citationDeuterium Dilution Technique for Body Composition Assessment: Resolving Methodological Issues in Children with Moderate Acute Malnutrition. 2017:1-12 Isotopes Environ Health Studen
dc.identifier.issn1477-2639-
dc.identifier.pmid28276731-
dc.identifier.doi10.1080/10256016.2017.1295043-
dc.identifier.urihttp://hdl.handle.net/10144/619013-
dc.descriptionAbstract available only. Full article is not Open Access. We regret that this article is behind a paywall.en
dc.description.abstractChildhood malnutrition is highly prevalent and associated with high mortality risk. In observational and interventional studies among malnourished children, body composition is increasingly recognised as a key outcome. The deuterium dilution technique has generated high-quality data on body composition in studies of infants and young children in several settings, but its feasibility and accuracy in children suffering from moderate acute malnutrition requires further study. Prior to a large nutritional intervention trial among children with moderate acute malnutrition, we conducted pilot work to develop and adapt the deuterium dilution technique. We refined procedures for administration of isotope doses and collection of saliva. Furthermore, we established that equilibration time in local context is 3 h. These findings and the resulting standard operating procedures are important to improve data quality when using the deuterium dilution technique in malnutrition studies in field conditions, and may encourage a wider use of isotope techniques.en
dc.language.isoenen
dc.publisherTaylor and Francisen
dc.relation.urlhttp://www.tandfonline.com/doi/abs/10.1080/10256016.2017.1295043en
dc.titleDeuterium Dilution Technique for Body Composition Assessment: Resolving Methodological Issues in Children with Moderate Acute Malnutritionen
dc.identifier.journalIsotopes in Environmental and Health Studiesen

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