A Novel Electronic Algorithm using Host Biomarker Point-of-Care tests for the Management of Febrile Illnesses in Tanzanian children (e-POCT): A randomized, controlled non-inferiority trial

Hdl Handle:
http://hdl.handle.net/10144/619040
Title:
A Novel Electronic Algorithm using Host Biomarker Point-of-Care tests for the Management of Febrile Illnesses in Tanzanian children (e-POCT): A randomized, controlled non-inferiority trial
Authors:
Keitel, K; Kagoro, F; Samaka, J; Masimba, J; Said, Z; Temba, H; Mlaganile, T; Sangu, W; Rambaud-Althaus, C; Gervaix, A; Genton, B; D'Acremont, V
Journal:
PLoS Medicine
Abstract:
The management of childhood infections remains inadequate in resource-limited countries, resulting in high mortality and irrational use of antimicrobials. Current disease management tools, such as the Integrated Management of Childhood Illness (IMCI) algorithm, rely solely on clinical signs and have not made use of available point-of-care tests (POCTs) that can help to identify children with severe infections and children in need of antibiotic treatment. e-POCT is a novel electronic algorithm based on current evidence; it guides clinicians through the entire consultation and recommends treatment based on a few clinical signs and POCT results, some performed in all patients (malaria rapid diagnostic test, hemoglobin, oximeter) and others in selected subgroups only (C-reactive protein, procalcitonin, glucometer). The objective of this trial was to determine whether the clinical outcome of febrile children managed by the e-POCT tool was non-inferior to that of febrile children managed by a validated electronic algorithm derived from IMCI (ALMANACH), while reducing the proportion with antibiotic prescription.
Publisher:
Public Library of Science
Issue Date:
23-Oct-2017
URI:
http://hdl.handle.net/10144/619040
DOI:
10.1371/journal.pmed.1002411
PubMed ID:
29059253
Submitted date:
2017-11-06
Language:
en
ISSN:
1549-1676
Appears in Collections:
Paediatrics

Full metadata record

DC FieldValue Language
dc.contributor.authorKeitel, Ken
dc.contributor.authorKagoro, Fen
dc.contributor.authorSamaka, Jen
dc.contributor.authorMasimba, Jen
dc.contributor.authorSaid, Zen
dc.contributor.authorTemba, Hen
dc.contributor.authorMlaganile, Ten
dc.contributor.authorSangu, Wen
dc.contributor.authorRambaud-Althaus, Cen
dc.contributor.authorGervaix, Aen
dc.contributor.authorGenton, Ben
dc.contributor.authorD'Acremont, Ven
dc.date.accessioned2017-11-13T05:19:59Z-
dc.date.available2017-11-13T05:19:59Z-
dc.date.issued2017-10-23-
dc.date.submitted2017-11-06-
dc.identifier.citationA Novel Electronic Algorithm using Host Biomarker Point-of-Care tests for the Management of Febrile Illnesses in Tanzanian children (e-POCT): A randomized, controlled non-inferiority trial. 2017, 14 (10):e1002411 PLoS Med.en
dc.identifier.issn1549-1676-
dc.identifier.pmid29059253-
dc.identifier.doi10.1371/journal.pmed.1002411-
dc.identifier.urihttp://hdl.handle.net/10144/619040-
dc.description.abstractThe management of childhood infections remains inadequate in resource-limited countries, resulting in high mortality and irrational use of antimicrobials. Current disease management tools, such as the Integrated Management of Childhood Illness (IMCI) algorithm, rely solely on clinical signs and have not made use of available point-of-care tests (POCTs) that can help to identify children with severe infections and children in need of antibiotic treatment. e-POCT is a novel electronic algorithm based on current evidence; it guides clinicians through the entire consultation and recommends treatment based on a few clinical signs and POCT results, some performed in all patients (malaria rapid diagnostic test, hemoglobin, oximeter) and others in selected subgroups only (C-reactive protein, procalcitonin, glucometer). The objective of this trial was to determine whether the clinical outcome of febrile children managed by the e-POCT tool was non-inferior to that of febrile children managed by a validated electronic algorithm derived from IMCI (ALMANACH), while reducing the proportion with antibiotic prescription.en
dc.language.isoenen
dc.publisherPublic Library of Scienceen
dc.rightsPublished by Public Library of Science, [url]http://medicine.plosjournals.org/[/url] Archived on this site by Open Access permissionen
dc.subject.meshAge of Onseten
dc.subject.meshAlgorithmsen
dc.subject.meshAnti-Bacterial Agentsen
dc.subject.meshBiomarkersen
dc.subject.meshChild, Preschoolen
dc.subject.meshClinical Decision-Makingen
dc.subject.meshCommunicable Diseasesen
dc.subject.meshDecision Support Techniquesen
dc.subject.meshDiagnosis, Computer-Assisteden
dc.subject.meshDiagnosis, Differentialen
dc.subject.meshFemaleen
dc.subject.meshFeveren
dc.subject.meshHeart Rateen
dc.subject.meshHumansen
dc.subject.meshInfanten
dc.subject.meshMaleen
dc.subject.meshMobile Applicationsen
dc.subject.meshNutritional Statusen
dc.subject.meshPatient Readmissionen
dc.subject.meshPatient Selectionen
dc.subject.meshPoint-of-Care Systemsen
dc.subject.meshPoint-of-Care Testingen
dc.subject.meshPredictive Value of Testsen
dc.subject.meshReproducibility of Resultsen
dc.subject.meshRespirationen
dc.subject.meshRisk Factorsen
dc.subject.meshSeverity of Illness Indexen
dc.subject.meshSmartphoneen
dc.subject.meshTanzaniaen
dc.titleA Novel Electronic Algorithm using Host Biomarker Point-of-Care tests for the Management of Febrile Illnesses in Tanzanian children (e-POCT): A randomized, controlled non-inferiority trialen
dc.identifier.journalPLoS Medicineen

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