Genomic History of the seventh Pandemic of Cholera in Africa

Hdl Handle:
http://hdl.handle.net/10144/619052
Title:
Genomic History of the seventh Pandemic of Cholera in Africa
Authors:
Weill, FX; Domman, D; Njamkepo, E; Tarr, C; Rauzier, J; Fawal, N; Keddy, KH; Salje, H; Moore, S; Mukhopadhyay, AK; Bercion, R; Luquero, FJ; Ngandjio, A; Dosso, M; Monakhova, E; Garin, B; Bouchier, C; Pazzani, C; Mutreja, A; Grunow, R; Sidikou, F; Bonte, L; Breurec, S; Damian, M; Njanpop-Lafourcade, BM; Sapriel, G; Page, AL; Hamze, M; Henkens, M; Chowdhury, G; Mengel, M; Koeck, JL; Fournier, JM; Dougan, G; Grimont, PAD; Parkhill, J; Holt, KE; Piarroux, R; Ramamurthy, T; Quilici, ML; Thomson, NR
Journal:
Science (New York, N.Y.)
Abstract:
The seventh cholera pandemic has heavily affected Africa, although the origin and continental spread of the disease remain undefined. We used genomic data from 1070 Vibrio cholerae O1 isolates, across 45 African countries and over a 49-year period, to show that past epidemics were attributable to a single expanded lineage. This lineage was introduced at least 11 times since 1970, into two main regions, West Africa and East/Southern Africa, causing epidemics that lasted up to 28 years. The last five introductions into Africa, all from Asia, involved multidrug-resistant sublineages that replaced antibiotic-susceptible sublineages after 2000. This phylogenetic framework describes the periodicity of lineage introduction and the stable routes of cholera spread, which should inform the rational design of control measures for cholera in Africa.
Publisher:
American Association for the Advancement of Science
Issue Date:
10-Nov-2017
URI:
http://hdl.handle.net/10144/619052
DOI:
10.1126/science.aad5901
PubMed ID:
29123067
Submitted date:
2017-12-13
Language:
en
ISSN:
1095-9203
Appears in Collections:
Other Diseases

Full metadata record

DC FieldValue Language
dc.contributor.authorWeill, FXen
dc.contributor.authorDomman, Den
dc.contributor.authorNjamkepo, Een
dc.contributor.authorTarr, Cen
dc.contributor.authorRauzier, Jen
dc.contributor.authorFawal, Nen
dc.contributor.authorKeddy, KHen
dc.contributor.authorSalje, Hen
dc.contributor.authorMoore, Sen
dc.contributor.authorMukhopadhyay, AKen
dc.contributor.authorBercion, Ren
dc.contributor.authorLuquero, FJen
dc.contributor.authorNgandjio, Aen
dc.contributor.authorDosso, Men
dc.contributor.authorMonakhova, Een
dc.contributor.authorGarin, Ben
dc.contributor.authorBouchier, Cen
dc.contributor.authorPazzani, Cen
dc.contributor.authorMutreja, Aen
dc.contributor.authorGrunow, Ren
dc.contributor.authorSidikou, Fen
dc.contributor.authorBonte, Len
dc.contributor.authorBreurec, Sen
dc.contributor.authorDamian, Men
dc.contributor.authorNjanpop-Lafourcade, BMen
dc.contributor.authorSapriel, Gen
dc.contributor.authorPage, ALen
dc.contributor.authorHamze, Men
dc.contributor.authorHenkens, Men
dc.contributor.authorChowdhury, Gen
dc.contributor.authorMengel, Men
dc.contributor.authorKoeck, JLen
dc.contributor.authorFournier, JMen
dc.contributor.authorDougan, Gen
dc.contributor.authorGrimont, PADen
dc.contributor.authorParkhill, Jen
dc.contributor.authorHolt, KEen
dc.contributor.authorPiarroux, Ren
dc.contributor.authorRamamurthy, Ten
dc.contributor.authorQuilici, MLen
dc.contributor.authorThomson, NRen
dc.date.accessioned2017-12-20T23:58:08Z-
dc.date.available2017-12-20T23:58:08Z-
dc.date.issued2017-11-10-
dc.date.submitted2017-12-13-
dc.identifier.citationGenomic History of the seventh Pandemic of Cholera in Africa. 2017, 358 (6364):785-789 Scienceen
dc.identifier.issn1095-9203-
dc.identifier.pmid29123067-
dc.identifier.doi10.1126/science.aad5901-
dc.identifier.urihttp://hdl.handle.net/10144/619052-
dc.description.abstractThe seventh cholera pandemic has heavily affected Africa, although the origin and continental spread of the disease remain undefined. We used genomic data from 1070 Vibrio cholerae O1 isolates, across 45 African countries and over a 49-year period, to show that past epidemics were attributable to a single expanded lineage. This lineage was introduced at least 11 times since 1970, into two main regions, West Africa and East/Southern Africa, causing epidemics that lasted up to 28 years. The last five introductions into Africa, all from Asia, involved multidrug-resistant sublineages that replaced antibiotic-susceptible sublineages after 2000. This phylogenetic framework describes the periodicity of lineage introduction and the stable routes of cholera spread, which should inform the rational design of control measures for cholera in Africa.en
dc.language.isoenen
dc.publisherAmerican Association for the Advancement of Scienceen
dc.rightsArchived with thanks to Science (New York, N.Y.)en
dc.titleGenomic History of the seventh Pandemic of Cholera in Africaen
dc.identifier.journalScience (New York, N.Y.)en

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