IPT during HIV treatment in Myanmar: high rates of coverage, completion and drug adherence

Hdl Handle:
http://hdl.handle.net/10144/619087
Title:
IPT during HIV treatment in Myanmar: high rates of coverage, completion and drug adherence
Authors:
Ousley, J; Soe, KP; Kyaw, NTT; Anicete, R; Mon, PE; Lwin, H; Win, T; Cristofani, S; Telnov, A; Fernandez, M; Ciglenecki, I
Journal:
Public Health Action
Abstract:
Setting: A southern Myanmar district providing isoniazid preventive therapy (IPT) in one of the last countries to formally recommend it as part of human immunodeficiency virus (HIV) care.Objective:To assess coverage and adherence and the feasibility of IPT scale-up in a routine care setting in Myanmar.Design:A retrospective analysis of people living with HIV (PLHIV) screened for tuberculosis (TB) and enrolled in IPT over a 3-year period (July 2011-June 2014) using clinical databases.Results:Among 3377 patients under HIV care and screened for TB, 2740 (81.1%) initiated IPT, with 2651 (96.8%) completing a 6- or 9-month course of IPT; 83 (3.1%) interrupted treatment for different reasons, including loss to follow-up (n= 41), side effects (n= 15) or drug adherence issues (n= 9); 6 (0.2%) died. Among the IPT patients, 33 (1.2%) were diagnosed with TB, including 9 (0.3%) while on IPT and 24 (0.9%) within 1 year of completion of therapy. Among the PLHIV who completed IPT, one case of isoniazid resistance was detected.Conclusion:Scaling up IPT in Myanmar HIV settings is feasible with high rates of drug adherence and completion, and a low rate of discontinuation due to side effects. IPT scale-up should be prioritised in HIV clinical settings in Myanmar.
Publisher:
International Union Against Tuberculosis and Lung Disease
Issue Date:
21-Mar-2018
URI:
http://hdl.handle.net/10144/619087
DOI:
10.5588/pha.17.0087
PubMed ID:
29581939
Submitted date:
2018-04-06
Language:
en
ISSN:
2220-8372
Appears in Collections:
HIV/AIDS

Full metadata record

DC FieldValue Language
dc.contributor.authorOusley, Jen
dc.contributor.authorSoe, KPen
dc.contributor.authorKyaw, NTTen
dc.contributor.authorAnicete, Ren
dc.contributor.authorMon, PEen
dc.contributor.authorLwin, Hen
dc.contributor.authorWin, Ten
dc.contributor.authorCristofani, Sen
dc.contributor.authorTelnov, Aen
dc.contributor.authorFernandez, Men
dc.contributor.authorCiglenecki, Ien
dc.date.accessioned2018-04-06T21:05:00Z-
dc.date.available2018-04-06T21:05:00Z-
dc.date.issued2018-03-21-
dc.date.submitted2018-04-06-
dc.identifier.citationIPT during HIV treatment in Myanmar: high rates of coverage, completion and drug adherence. 2018, 8 (1):20-24 Public Health Actionen
dc.identifier.issn2220-8372-
dc.identifier.pmid29581939-
dc.identifier.doi10.5588/pha.17.0087-
dc.identifier.urihttp://hdl.handle.net/10144/619087-
dc.description.abstractSetting: A southern Myanmar district providing isoniazid preventive therapy (IPT) in one of the last countries to formally recommend it as part of human immunodeficiency virus (HIV) care.Objective:To assess coverage and adherence and the feasibility of IPT scale-up in a routine care setting in Myanmar.Design:A retrospective analysis of people living with HIV (PLHIV) screened for tuberculosis (TB) and enrolled in IPT over a 3-year period (July 2011-June 2014) using clinical databases.Results:Among 3377 patients under HIV care and screened for TB, 2740 (81.1%) initiated IPT, with 2651 (96.8%) completing a 6- or 9-month course of IPT; 83 (3.1%) interrupted treatment for different reasons, including loss to follow-up (n= 41), side effects (n= 15) or drug adherence issues (n= 9); 6 (0.2%) died. Among the IPT patients, 33 (1.2%) were diagnosed with TB, including 9 (0.3%) while on IPT and 24 (0.9%) within 1 year of completion of therapy. Among the PLHIV who completed IPT, one case of isoniazid resistance was detected.Conclusion:Scaling up IPT in Myanmar HIV settings is feasible with high rates of drug adherence and completion, and a low rate of discontinuation due to side effects. IPT scale-up should be prioritised in HIV clinical settings in Myanmar.en
dc.language.isoenen
dc.publisherInternational Union Against Tuberculosis and Lung Diseaseen
dc.rightsArchived with thanks to Public Health Actionen
dc.titleIPT during HIV treatment in Myanmar: high rates of coverage, completion and drug adherenceen
dc.identifier.journalPublic Health Actionen

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