Molecular markers of resistance to amodiaquine plus sulfadoxine-pyrimethamine in an area with seasonal malaria chemoprevention in south central Niger

Hdl Handle:
http://hdl.handle.net/10144/619099
Title:
Molecular markers of resistance to amodiaquine plus sulfadoxine-pyrimethamine in an area with seasonal malaria chemoprevention in south central Niger
Authors:
Grais, RF; Laminou, IM; Woi-Messe, L; Makarimi, R; Bouriema, SH; Langendorf, C; Amambua-Ngwa, A; D'Alessandro, U; Guérin, PJ; Fandeur, T; Sibley, CH
Journal:
Malaria Journal
Abstract:
In Niger, malaria transmission is markedly seasonal with most of the disease burden occurring in children during the rainy season. Seasonal malaria chemoprevention (SMC) with amodiaquine plus sulfadoxine-pyrimethamine (AQ + SP) is recommended in the country to be administered monthly just before and during the rainy season. Moreover, clinical decisions on use of SP for intermittent preventive treatment in pregnancy (IPTp) now depend upon the validated molecular markers for SP resistance in Plasmodium falciparum observed in the local parasite population. However, little is known about molecular markers of resistance for either SP or AQ in the south of Niger. To address this question, clinical samples which met clinical and biological criteria, were collected in Gabi, Madarounfa district, Maradi region, Niger in 2011-2012 (before SMC implementation). Molecular markers of resistance to pyrimethamine (pfdhfr), sulfadoxine (pfdhps) and amodiaquine (pfmdr1) were assessed by DNA sequencing.
Publisher:
BioMed Central
Issue Date:
27-Feb-2018
URI:
http://hdl.handle.net/10144/619099
DOI:
10.1186/s12936-018-2242-4
PubMed ID:
29486766
Submitted date:
2018-04-17
Language:
en
ISSN:
1475-2875
Appears in Collections:
Malaria

Full metadata record

DC FieldValue Language
dc.contributor.authorGrais, RFen
dc.contributor.authorLaminou, IMen
dc.contributor.authorWoi-Messe, Len
dc.contributor.authorMakarimi, Ren
dc.contributor.authorBouriema, SHen
dc.contributor.authorLangendorf, Cen
dc.contributor.authorAmambua-Ngwa, Aen
dc.contributor.authorD'Alessandro, Uen
dc.contributor.authorGuérin, PJen
dc.contributor.authorFandeur, Ten
dc.contributor.authorSibley, CHen
dc.date.accessioned2018-04-23T12:31:25Z-
dc.date.available2018-04-23T12:31:25Z-
dc.date.issued2018-02-27-
dc.date.submitted2018-04-17-
dc.identifier.citationMolecular markers of resistance to amodiaquine plus sulfadoxine-pyrimethamine in an area with seasonal malaria chemoprevention in south central Niger. 2018, 17 (1):98 Malar. J.en
dc.identifier.issn1475-2875-
dc.identifier.pmid29486766-
dc.identifier.doi10.1186/s12936-018-2242-4-
dc.identifier.urihttp://hdl.handle.net/10144/619099-
dc.description.abstractIn Niger, malaria transmission is markedly seasonal with most of the disease burden occurring in children during the rainy season. Seasonal malaria chemoprevention (SMC) with amodiaquine plus sulfadoxine-pyrimethamine (AQ + SP) is recommended in the country to be administered monthly just before and during the rainy season. Moreover, clinical decisions on use of SP for intermittent preventive treatment in pregnancy (IPTp) now depend upon the validated molecular markers for SP resistance in Plasmodium falciparum observed in the local parasite population. However, little is known about molecular markers of resistance for either SP or AQ in the south of Niger. To address this question, clinical samples which met clinical and biological criteria, were collected in Gabi, Madarounfa district, Maradi region, Niger in 2011-2012 (before SMC implementation). Molecular markers of resistance to pyrimethamine (pfdhfr), sulfadoxine (pfdhps) and amodiaquine (pfmdr1) were assessed by DNA sequencing.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.rightsPublished by BioMed Central, [url]http://www.malariajournal.com/[/url] Archived on this site by Open Access permissionen
dc.titleMolecular markers of resistance to amodiaquine plus sulfadoxine-pyrimethamine in an area with seasonal malaria chemoprevention in south central Nigeren
dc.identifier.journalMalaria Journalen

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