The incubation period of hepatitis E genotype 1: insights from pooled analyses of travellers

Hdl Handle:
http://hdl.handle.net/10144/619181
Title:
The incubation period of hepatitis E genotype 1: insights from pooled analyses of travellers
Authors:
Azman, AS; Ciglenecki, I; Oeser, C; Said, B; Tedder, RS; Ijaz, S
Journal:
Epidemiology and Infection
Abstract:
Hepatitis E virus genotype 1 (HEV G1) is an important cause of morbidity and mortality in Africa and Asia. HEV G1's natural history, including the incubation period, remains poorly understood, hindering surveillance efforts and effective control. Using individual-level data from 85 travel-related HEV G1 cases in England and Wales, we estimate the incubation period distribution using survival analysis methods, which allow for appropriate inference when only time ranges, rather than exact times are known for the exposure to HEV and symptom onset. We estimated a 29.8-day (95% confidence interval (CI) 24.1-36.0) median incubation period with 5% of people expected to develop symptoms within 14.3 days (95% CI 10.1-21.7) and 95% within 61.9 days (95% CI 47.4-74.4) of exposure. These estimates can help refine clinical case definitions and inform the design of disease burden and intervention studies.
Publisher:
Cambridge University Press
Issue Date:
24-May-2018
URI:
http://hdl.handle.net/10144/619181
DOI:
10.1017/S0950268818001097
PubMed ID:
29792586
Submitted date:
2018-06-04
Language:
en
Description:
We regret that this article is behind a paywall.
ISSN:
1469-4409
Appears in Collections:
Other Diseases

Full metadata record

DC FieldValue Language
dc.contributor.authorAzman, ASen
dc.contributor.authorCiglenecki, Ien
dc.contributor.authorOeser, Cen
dc.contributor.authorSaid, Ben
dc.contributor.authorTedder, RSen
dc.contributor.authorIjaz, Sen
dc.date.accessioned2018-06-20T17:06:11Z-
dc.date.available2018-06-20T17:06:11Z-
dc.date.issued2018-05-24-
dc.date.submitted2018-06-04-
dc.identifier.citationThe incubation period of hepatitis E genotype 1: insights from pooled analyses of travellers. 2018:1-4 Epidemiol. Infect.en
dc.identifier.issn1469-4409-
dc.identifier.pmid29792586-
dc.identifier.doi10.1017/S0950268818001097-
dc.identifier.urihttp://hdl.handle.net/10144/619181-
dc.descriptionWe regret that this article is behind a paywall.en
dc.description.abstractHepatitis E virus genotype 1 (HEV G1) is an important cause of morbidity and mortality in Africa and Asia. HEV G1's natural history, including the incubation period, remains poorly understood, hindering surveillance efforts and effective control. Using individual-level data from 85 travel-related HEV G1 cases in England and Wales, we estimate the incubation period distribution using survival analysis methods, which allow for appropriate inference when only time ranges, rather than exact times are known for the exposure to HEV and symptom onset. We estimated a 29.8-day (95% confidence interval (CI) 24.1-36.0) median incubation period with 5% of people expected to develop symptoms within 14.3 days (95% CI 10.1-21.7) and 95% within 61.9 days (95% CI 47.4-74.4) of exposure. These estimates can help refine clinical case definitions and inform the design of disease burden and intervention studies.en
dc.language.isoenen
dc.publisherCambridge University Pressen
dc.titleThe incubation period of hepatitis E genotype 1: insights from pooled analyses of travellersen
dc.identifier.journalEpidemiology and Infectionen

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