Artemether-lumefantrine dosing for malaria treatment in young children and pregnant women: A pharmacokinetic-pharmacodynamic meta-analysis

Hdl Handle:
http://hdl.handle.net/10144/619189
Title:
Artemether-lumefantrine dosing for malaria treatment in young children and pregnant women: A pharmacokinetic-pharmacodynamic meta-analysis
Authors:
Kloprogge, F; Workman, L; Borrmann, S; Tékété, M; Lefèvre, G; Hamed, K; Piola, P; Ursing, J; Kofoed, PE; Mårtensson, A; Ngasala, B; Björkman, A; Ashton, M; Friberg Hietala, S; Aweeka, F; Parikh, S; Mwai, L; Davis, T; Karunajeewa, H; Salman, S; Checchi, F; Fogg, C; Newton, PN; Mayxay, M; Deloron, P; Faucher, JF; Nosten, F; Ashley, EA; McGready, R; van Vugt, M; Proux, S; Price, RN; Karbwang, J; Ezzet, F; Bakshi, R; Stepniewska, K; White, NJ; Guerin, PJ; Barnes, KI; Tarning, J
Journal:
PLoS Medicine
Abstract:
The fixed dose combination of artemether-lumefantrine (AL) is the most widely used treatment for uncomplicated Plasmodium falciparum malaria. Relatively lower cure rates and lumefantrine levels have been reported in young children and in pregnant women during their second and third trimester. The aim of this study was to investigate the pharmacokinetic and pharmacodynamic properties of lumefantrine and the pharmacokinetic properties of its metabolite, desbutyl-lumefantrine, in order to inform optimal dosing regimens in all patient populations.
Publisher:
Public Library of Science
Issue Date:
Jun-2018
URI:
http://hdl.handle.net/10144/619189
DOI:
10.1371/journal.pmed.1002579
PubMed ID:
29894518
Submitted date:
2018-06-26
Language:
en
ISSN:
1549-1676
Appears in Collections:
Malaria

Full metadata record

DC FieldValue Language
dc.contributor.authorKloprogge, Fen
dc.contributor.authorWorkman, Len
dc.contributor.authorBorrmann, Sen
dc.contributor.authorTékété, Men
dc.contributor.authorLefèvre, Gen
dc.contributor.authorHamed, Ken
dc.contributor.authorPiola, Pen
dc.contributor.authorUrsing, Jen
dc.contributor.authorKofoed, PEen
dc.contributor.authorMårtensson, Aen
dc.contributor.authorNgasala, Ben
dc.contributor.authorBjörkman, Aen
dc.contributor.authorAshton, Men
dc.contributor.authorFriberg Hietala, Sen
dc.contributor.authorAweeka, Fen
dc.contributor.authorParikh, Sen
dc.contributor.authorMwai, Len
dc.contributor.authorDavis, Ten
dc.contributor.authorKarunajeewa, Hen
dc.contributor.authorSalman, Sen
dc.contributor.authorChecchi, Fen
dc.contributor.authorFogg, Cen
dc.contributor.authorNewton, PNen
dc.contributor.authorMayxay, Men
dc.contributor.authorDeloron, Pen
dc.contributor.authorFaucher, JFen
dc.contributor.authorNosten, Fen
dc.contributor.authorAshley, EAen
dc.contributor.authorMcGready, Ren
dc.contributor.authorvan Vugt, Men
dc.contributor.authorProux, Sen
dc.contributor.authorPrice, RNen
dc.contributor.authorKarbwang, Jen
dc.contributor.authorEzzet, Fen
dc.contributor.authorBakshi, Ren
dc.contributor.authorStepniewska, Ken
dc.contributor.authorWhite, NJen
dc.contributor.authorGuerin, PJen
dc.contributor.authorBarnes, KIen
dc.contributor.authorTarning, Jen
dc.date.accessioned2018-06-27T12:04:52Z-
dc.date.available2018-06-27T12:04:52Z-
dc.date.issued2018-06-
dc.date.submitted2018-06-26-
dc.identifier.citationArtemether-lumefantrine dosing for malaria treatment in young children and pregnant women: A pharmacokinetic-pharmacodynamic meta-analysis. 2018, 15 (6):e1002579 PLoS Med.en
dc.identifier.issn1549-1676-
dc.identifier.pmid29894518-
dc.identifier.doi10.1371/journal.pmed.1002579-
dc.identifier.urihttp://hdl.handle.net/10144/619189-
dc.description.abstractThe fixed dose combination of artemether-lumefantrine (AL) is the most widely used treatment for uncomplicated Plasmodium falciparum malaria. Relatively lower cure rates and lumefantrine levels have been reported in young children and in pregnant women during their second and third trimester. The aim of this study was to investigate the pharmacokinetic and pharmacodynamic properties of lumefantrine and the pharmacokinetic properties of its metabolite, desbutyl-lumefantrine, in order to inform optimal dosing regimens in all patient populations.en
dc.language.isoenen
dc.publisherPublic Library of Scienceen
dc.rightsPublished by Public Library of Science, [url]http://medicine.plosjournals.org/[/url] Archived on this site by Open Access permissionen
dc.titleArtemether-lumefantrine dosing for malaria treatment in young children and pregnant women: A pharmacokinetic-pharmacodynamic meta-analysisen
dc.identifier.journalPLoS Medicineen

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