Field evaluation of the performance of HCV Serological Rapid Diagnostic Tests among HCV/HIV co-infected patients

Hdl Handle:
http://hdl.handle.net/10144/619216
Title:
Field evaluation of the performance of HCV Serological Rapid Diagnostic Tests among HCV/HIV co-infected patients
Authors:
Gupta, Ekta; Carnimeo, Valentina; Samukcham, Inao; Loarec, Anne; Mahajan, Supriya; Choudhary, Manish; Bastard, Mathieu; Maman, David; Page, Anne Laure
Abstract:
P R O T O C O L S U M M A R Y  Title: Field evaluation of the performance of HCV Serological Rapid Diagnostic Tests among HCV/HIV co-infected patients.  Aim: To evaluate the performance of serological HCV Rapid Diagnostic Tests (RDTs) to identify tests adapted to resource-limited settings, reliable for HIV-infected patients.  Study design: Prospective evaluation of the performance of serological RDTs for HCV screening.  Primary objective: o To evaluate the performance of serological HCV RDTs under field conditions using as reference standard a combination of enzyme immunoassay (EIA) and recombinant immunoblot assay (RIBA) for the detection of antibodies anti-HCV in HIV infected patients.  Secondary objectives: o To describe the accuracy (sensitivity, specificity) of the RDTs as screening tests o To describe the performance of the RDTs according to the HCV genotype and HCV VL o To describe the performance of the RDTs according to the CD4 counts and HIV VL o To describe the performance of the RDTs in presence of HBV co-infection (presence of antigen anti-HBs (HBsAg)) o To describe the operational characteristics of the tests including ease of use, technical complexity and inter-reader variability. o To evaluate predictive values of each HCV RDT based on the prevalence of the testing center.
Affiliation:
MSF-OCA
Issue Date:
Jul-2018
URI:
http://hdl.handle.net/10144/619216
Type:
Other
Language:
en
Description:
Research Protocol
Appears in Collections:
MSF Research Protocols

Full metadata record

DC FieldValue Language
dc.contributor.authorGupta, Ektaen
dc.contributor.authorCarnimeo, Valentinaen
dc.contributor.authorSamukcham, Inaoen
dc.contributor.authorLoarec, Anneen
dc.contributor.authorMahajan, Supriyaen
dc.contributor.authorChoudhary, Manishen
dc.contributor.authorBastard, Mathieuen
dc.contributor.authorMaman, Daviden
dc.contributor.authorPage, Anne Laureen
dc.date.accessioned2018-07-27T10:57:28Z-
dc.date.available2018-07-27T10:57:28Z-
dc.date.issued2018-07-
dc.identifier.urihttp://hdl.handle.net/10144/619216-
dc.descriptionResearch Protocolen
dc.description.abstractP R O T O C O L S U M M A R Y  Title: Field evaluation of the performance of HCV Serological Rapid Diagnostic Tests among HCV/HIV co-infected patients.  Aim: To evaluate the performance of serological HCV Rapid Diagnostic Tests (RDTs) to identify tests adapted to resource-limited settings, reliable for HIV-infected patients.  Study design: Prospective evaluation of the performance of serological RDTs for HCV screening.  Primary objective: o To evaluate the performance of serological HCV RDTs under field conditions using as reference standard a combination of enzyme immunoassay (EIA) and recombinant immunoblot assay (RIBA) for the detection of antibodies anti-HCV in HIV infected patients.  Secondary objectives: o To describe the accuracy (sensitivity, specificity) of the RDTs as screening tests o To describe the performance of the RDTs according to the HCV genotype and HCV VL o To describe the performance of the RDTs according to the CD4 counts and HIV VL o To describe the performance of the RDTs in presence of HBV co-infection (presence of antigen anti-HBs (HBsAg)) o To describe the operational characteristics of the tests including ease of use, technical complexity and inter-reader variability. o To evaluate predictive values of each HCV RDT based on the prevalence of the testing center.en
dc.language.isoenen
dc.rightsThese materials can be used, adapted and copied as long as citation of the source is given including the direct URL to the material. This work is licensed under a Creative Commons Attribution 4.0 International License: http://creativecommons.org/licenses/by/4.0/ https://i.creativecommons.org/l/by/4.0/88x31.pngen
dc.subjectfield evaluationen
dc.subjectHCV Serologicalen
dc.subjectHCV/HIVen
dc.subjectRapid Diagnostic Testsen
dc.titleField evaluation of the performance of HCV Serological Rapid Diagnostic Tests among HCV/HIV co-infected patientsen
dc.typeOtheren
dc.contributor.departmentMSF-OCAen
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