Prevalence and vaccination coverage of Hepatitis B among healthcare workers in Cameroon: A national seroprevalence survey

Hdl Handle:
http://hdl.handle.net/10144/619260
Title:
Prevalence and vaccination coverage of Hepatitis B among healthcare workers in Cameroon: A national seroprevalence survey
Authors:
Bilounga Ndongo, C; Eteki, L; Siedner, M; Mbaye, R; Chen, J; Ntone, R; Donfack, O; Bongwong, B; Essaka, RE; Zeh, F; Njouom, R; Nguefack-Tsague, Georges; Etoundi, GAM; Biwole Sida, M; Boum, Y
Journal:
Journal of Viral Hepatitis
Abstract:
Hepatitis B virus (HBV) infection is hyperendemic in Cameroon, and health care workers (HCWs) are at high-risk of infection. We aimed to assess prevalence, risk factors and vaccine coverage of HBV infection among HCWs in Cameroon. We conducted a cross-sectional study in 16 hospitals across all regions of Cameroon. HCWs were tested for HBV using rapid diagnostic tests (RDT). We collected data on socio-demographics and HBV vaccination status. We estimated prevalence of HBV and used Poisson regression models with robust standard errors to model the prevalence ratios of HBV positivity between covariates. We enrolled 1,824 of 1,836 eligible HCWs (97.5%). The mean age was 34 (SD: 10) years, 65.3% (n=1787) were women, and 11.4% (n=1747) had three or more doses of the HBV vaccine. Overall, we found a HBV prevalence of 8.7% (95% CI: 5.2 - 14.3%). Patient transporters had the highest crude prevalence (14.3%; 95%CI: 5.4-32.9%), whereas medical doctors had the lowest (3.2%; 95%CI: 0.8%-12.1%). The Far North Region had the highest prevalence of HBV (24.0%; 95%CI: 18.3%-30.8%). HBV prevalence decreased with increasing doses of the HBV vaccine (10.3% for no doses vs 3.5% for three or more doses; P<0.001). In conclusion, approximately 1 in 12 HCWs in Cameroon have evidence of HBV infection, yet fewer than 1 in 6 have been fully vaccinated. Our results illustrate the urgent need to scale up systematic HBV screening and targeted vaccination of HCWs in the region. This article is protected by copyright. All rights reserved.
Publisher:
Wiley-Blackwell
Issue Date:
26-Jul-2018
URI:
http://hdl.handle.net/10144/619260
DOI:
10.1111/jvh.12974
PubMed ID:
30047565
Submitted date:
2018-08-07
Language:
en
ISSN:
1365-2893
Appears in Collections:
Other Diseases

Full metadata record

DC FieldValue Language
dc.contributor.authorBilounga Ndongo, Cen
dc.contributor.authorEteki, Len
dc.contributor.authorSiedner, Men
dc.contributor.authorMbaye, Ren
dc.contributor.authorChen, Jen
dc.contributor.authorNtone, Ren
dc.contributor.authorDonfack, Oen
dc.contributor.authorBongwong, Ben
dc.contributor.authorEssaka, REen
dc.contributor.authorZeh, Fen
dc.contributor.authorNjouom, Ren
dc.contributor.authorNguefack-Tsague, Georgesen
dc.contributor.authorEtoundi, GAMen
dc.contributor.authorBiwole Sida, Men
dc.contributor.authorBoum, Yen
dc.date.accessioned2018-08-19T14:20:28Z-
dc.date.available2018-08-19T14:20:28Z-
dc.date.issued2018-07-26-
dc.date.submitted2018-08-07-
dc.identifier.citationPrevalence and vaccination coverage of Hepatitis B among healthcare workers in Cameroon: A national seroprevalence survey. 2018 J. Viral Hepat.en
dc.identifier.issn1365-2893-
dc.identifier.pmid30047565-
dc.identifier.doi10.1111/jvh.12974-
dc.identifier.urihttp://hdl.handle.net/10144/619260-
dc.description.abstractHepatitis B virus (HBV) infection is hyperendemic in Cameroon, and health care workers (HCWs) are at high-risk of infection. We aimed to assess prevalence, risk factors and vaccine coverage of HBV infection among HCWs in Cameroon. We conducted a cross-sectional study in 16 hospitals across all regions of Cameroon. HCWs were tested for HBV using rapid diagnostic tests (RDT). We collected data on socio-demographics and HBV vaccination status. We estimated prevalence of HBV and used Poisson regression models with robust standard errors to model the prevalence ratios of HBV positivity between covariates. We enrolled 1,824 of 1,836 eligible HCWs (97.5%). The mean age was 34 (SD: 10) years, 65.3% (n=1787) were women, and 11.4% (n=1747) had three or more doses of the HBV vaccine. Overall, we found a HBV prevalence of 8.7% (95% CI: 5.2 - 14.3%). Patient transporters had the highest crude prevalence (14.3%; 95%CI: 5.4-32.9%), whereas medical doctors had the lowest (3.2%; 95%CI: 0.8%-12.1%). The Far North Region had the highest prevalence of HBV (24.0%; 95%CI: 18.3%-30.8%). HBV prevalence decreased with increasing doses of the HBV vaccine (10.3% for no doses vs 3.5% for three or more doses; P<0.001). In conclusion, approximately 1 in 12 HCWs in Cameroon have evidence of HBV infection, yet fewer than 1 in 6 have been fully vaccinated. Our results illustrate the urgent need to scale up systematic HBV screening and targeted vaccination of HCWs in the region. This article is protected by copyright. All rights reserved.en
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.rightsArchived with thanks to Journal of Viral Hepatitisen
dc.titlePrevalence and vaccination coverage of Hepatitis B among healthcare workers in Cameroon: A national seroprevalence surveyen
dc.identifier.journalJournal of Viral Hepatitisen

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