Adherence to Nucleos(t)ide Analogue Therapies for Chronic Hepatitis B Infection: A Systematic Review and Meta-Analysis

Hdl Handle:
http://hdl.handle.net/10144/619267
Title:
Adherence to Nucleos(t)ide Analogue Therapies for Chronic Hepatitis B Infection: A Systematic Review and Meta-Analysis
Authors:
Ford, N; Scourse, R; Lemoine, M; Hutin, Y; Bulterys, M; Shubber, Z; Donchuk, D; Wandeler, G
Journal:
Hepatology Communications
Abstract:
Successful treatment outcomes for chronic hepatitis B virus (HBV) infection requires high levels of adherence to treatment. We searched three databases and abstracts from two conferences up to January 2018 for studies reporting the proportion of patients who were adherent to HBV antiviral therapy and pooled data using random effects meta-analysis. We included 30 studies, providing data for 23,823 patients. Overall, adherence to treatment was 74.6% (95% confidence interval [CI] 67.1%-82.1%). Adherence was similar in high-income settings (75.1%; 95% CI, 65.4%-85.0%) and in low-income and middle-income settings (72.9%; 95% CI, 57.8%-88.0%). Reported barriers to adherence included forgetting, limited understanding of the importance of adherence, and change to routine. Conclusion : There is a need to reinforce assessment and reporting of adherence as a routine part of HBV care and to assess the extent to which evidence-based interventions to improve adherence to medication for human immunodeficiency virus [HIV] and other chronic diseases are effective for HBV infection.
Publisher:
Wiley Open Access
Issue Date:
25-Sep-2018
URI:
http://hdl.handle.net/10144/619267
DOI:
10.1002/hep4.1247
PubMed ID:
30288470
Submitted date:
2018-10-15
Language:
en
ISSN:
2471-254X
Appears in Collections:
Other Diseases

Full metadata record

DC FieldValue Language
dc.contributor.authorFord, Nen
dc.contributor.authorScourse, Ren
dc.contributor.authorLemoine, Men
dc.contributor.authorHutin, Yen
dc.contributor.authorBulterys, Men
dc.contributor.authorShubber, Zen
dc.contributor.authorDonchuk, Den
dc.contributor.authorWandeler, Gen
dc.date.accessioned2018-10-16T16:30:02Z-
dc.date.available2018-10-16T16:30:02Z-
dc.date.issued2018-09-25-
dc.date.submitted2018-10-15-
dc.identifier.citationAdherence to Nucleos(t)ide Analogue Therapies for Chronic Hepatitis B Infection: A Systematic Review and Meta-Analysis. 2018, 2 (10):1160-1167 Hepatol Communen
dc.identifier.issn2471-254X-
dc.identifier.pmid30288470-
dc.identifier.doi10.1002/hep4.1247-
dc.identifier.urihttp://hdl.handle.net/10144/619267-
dc.description.abstractSuccessful treatment outcomes for chronic hepatitis B virus (HBV) infection requires high levels of adherence to treatment. We searched three databases and abstracts from two conferences up to January 2018 for studies reporting the proportion of patients who were adherent to HBV antiviral therapy and pooled data using random effects meta-analysis. We included 30 studies, providing data for 23,823 patients. Overall, adherence to treatment was 74.6% (95% confidence interval [CI] 67.1%-82.1%). Adherence was similar in high-income settings (75.1%; 95% CI, 65.4%-85.0%) and in low-income and middle-income settings (72.9%; 95% CI, 57.8%-88.0%). Reported barriers to adherence included forgetting, limited understanding of the importance of adherence, and change to routine. Conclusion : There is a need to reinforce assessment and reporting of adherence as a routine part of HBV care and to assess the extent to which evidence-based interventions to improve adherence to medication for human immunodeficiency virus [HIV] and other chronic diseases are effective for HBV infection.en
dc.language.isoenen
dc.publisherWiley Open Accessen
dc.rightsArchived with thanks to Hepatology Communicationsen
dc.titleAdherence to Nucleos(t)ide Analogue Therapies for Chronic Hepatitis B Infection: A Systematic Review and Meta-Analysisen
dc.identifier.journalHepatology Communicationsen

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