Reactive and pre-emptive vaccination strategies to control hepatitis E infection in emergency and refugee settings: A modelling study

Hdl Handle:
http://hdl.handle.net/10144/619278
Title:
Reactive and pre-emptive vaccination strategies to control hepatitis E infection in emergency and refugee settings: A modelling study
Authors:
Cooper, BS; White, LJ; Siddiqui, R
Journal:
PLoS Neglected Tropical Diseases
Abstract:
Hepatitis E Virus (HEV) is the leading cause of acute viral hepatitis globally. Symptomatic infection is associated with case fatality rates of ~20% in pregnant women and it is estimated to account for ~10,000 annual pregnancy-related deaths in southern Asia alone. Recently, large and well-documented outbreaks with high mortality have occurred in displaced population camps in Sudan, Uganda and South Sudan. However, the epidemiology of HEV is poorly defined, and the value of different immunisation strategies in outbreak settings uncertain. We aimed to estimate the critical epidemiological parameters for HEV and to evaluate the potential impact of both reactive vaccination (initiated in response to an epidemic) and pre-emptive vaccination.
Publisher:
Public Library of Science
Issue Date:
25-Sep-2018
URI:
http://hdl.handle.net/10144/619278
DOI:
10.1371/journal.pntd.0006807
PubMed ID:
30252843
Submitted date:
2018-10-04
Language:
en
ISSN:
1935-2735
Appears in Collections:
Vaccination

Full metadata record

DC FieldValue Language
dc.contributor.authorCooper, BSen
dc.contributor.authorWhite, LJen
dc.contributor.authorSiddiqui, Ren
dc.date.accessioned2018-10-16T16:41:52Z-
dc.date.available2018-10-16T16:41:52Z-
dc.date.issued2018-09-25-
dc.date.submitted2018-10-04-
dc.identifier.citationReactive and pre-emptive vaccination strategies to control hepatitis E infection in emergency and refugee settings: A modelling study. 2018, 12 (9):e0006807 PLoS Negl Trop Disen
dc.identifier.issn1935-2735-
dc.identifier.pmid30252843-
dc.identifier.doi10.1371/journal.pntd.0006807-
dc.identifier.urihttp://hdl.handle.net/10144/619278-
dc.description.abstractHepatitis E Virus (HEV) is the leading cause of acute viral hepatitis globally. Symptomatic infection is associated with case fatality rates of ~20% in pregnant women and it is estimated to account for ~10,000 annual pregnancy-related deaths in southern Asia alone. Recently, large and well-documented outbreaks with high mortality have occurred in displaced population camps in Sudan, Uganda and South Sudan. However, the epidemiology of HEV is poorly defined, and the value of different immunisation strategies in outbreak settings uncertain. We aimed to estimate the critical epidemiological parameters for HEV and to evaluate the potential impact of both reactive vaccination (initiated in response to an epidemic) and pre-emptive vaccination.en
dc.language.isoenen
dc.publisherPublic Library of Scienceen
dc.rightsArchived with thanks to PLoS Neglected Tropical Diseasesen
dc.titleReactive and pre-emptive vaccination strategies to control hepatitis E infection in emergency and refugee settings: A modelling studyen
dc.identifier.journalPLoS Neglected Tropical Diseasesen

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