Progress and Challenges in Using Oral Cholera Vaccines to Control Outbreaks: The Médecins Sans Frontières Experience

Hdl Handle:
http://hdl.handle.net/10144/619281
Title:
Progress and Challenges in Using Oral Cholera Vaccines to Control Outbreaks: The Médecins Sans Frontières Experience
Authors:
Ciglenecki, I; Azman, AS; Jamet, C; Serafini, M; Luquero, FJ; Cabrol, JC
Journal:
The Journal of Infectious Diseases
Abstract:
The use of oral cholera vaccine (OCV) has increased since 2011, when Shanchol, the first OCV suitable for large-scale use, became available. Médecins Sans Frontières considers OCVs an essential cholera outbreak control tool and has contributed to generating new evidence on OCV use in outbreaks. We showed that large-scale mass campaigns are feasible during outbreaks, documented high short-term effectiveness and showed that vaccines are likely safe in pregnancy. We found that a single-dose regimen has high short-term effectiveness, making rapid delivery of vaccine during outbreaks easier, especially given the on-going global vaccine shortage. Despite progress, OCV has still not been used widely in some of the largest recent outbreaks and thousands of cholera deaths are reported every year. While working towards improving our tools to protect those most at-risk of cholera, we must strive to use all available effective interventions in efficient ways, including OCV, to prevent avoidable deaths today.
Publisher:
Oxford University Press
Issue Date:
14-Sep-2018
URI:
http://hdl.handle.net/10144/619281
DOI:
10.1093/infdis/jiy487
PubMed ID:
30239901
Submitted date:
2018-10-04
Language:
en
ISSN:
1537-6613
Appears in Collections:
Vaccination

Full metadata record

DC FieldValue Language
dc.contributor.authorCiglenecki, Ien
dc.contributor.authorAzman, ASen
dc.contributor.authorJamet, Cen
dc.contributor.authorSerafini, Men
dc.contributor.authorLuquero, FJen
dc.contributor.authorCabrol, JCen
dc.date.accessioned2018-10-16T16:46:35Z-
dc.date.available2018-10-16T16:46:35Z-
dc.date.issued2018-09-14-
dc.date.submitted2018-10-04-
dc.identifier.citationProgress and Challenges in Using Oral Cholera Vaccines to Control Outbreaks: The Médecins Sans Frontières Experience. 2018 J. Infect. Dis.en
dc.identifier.issn1537-6613-
dc.identifier.pmid30239901-
dc.identifier.doi10.1093/infdis/jiy487-
dc.identifier.urihttp://hdl.handle.net/10144/619281-
dc.description.abstractThe use of oral cholera vaccine (OCV) has increased since 2011, when Shanchol, the first OCV suitable for large-scale use, became available. Médecins Sans Frontières considers OCVs an essential cholera outbreak control tool and has contributed to generating new evidence on OCV use in outbreaks. We showed that large-scale mass campaigns are feasible during outbreaks, documented high short-term effectiveness and showed that vaccines are likely safe in pregnancy. We found that a single-dose regimen has high short-term effectiveness, making rapid delivery of vaccine during outbreaks easier, especially given the on-going global vaccine shortage. Despite progress, OCV has still not been used widely in some of the largest recent outbreaks and thousands of cholera deaths are reported every year. While working towards improving our tools to protect those most at-risk of cholera, we must strive to use all available effective interventions in efficient ways, including OCV, to prevent avoidable deaths today.en
dc.language.isoenen
dc.publisherOxford University Pressen
dc.rightsPublished by Infectious Diseases Society of America Archived on this site with permission and copyright 200X by the Infectious Diseases Society of America, [url] and Oxford University Pressen
dc.titleProgress and Challenges in Using Oral Cholera Vaccines to Control Outbreaks: The Médecins Sans Frontières Experienceen
dc.identifier.journalThe Journal of Infectious Diseasesen

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