Prevalence and risk factors of brucellosis among febrile patients attending a community hospital in south western Uganda

Hdl Handle:
http://hdl.handle.net/10144/619298
Title:
Prevalence and risk factors of brucellosis among febrile patients attending a community hospital in south western Uganda
Authors:
Migisha, R; Dan N; Boum, Y; Page, AL; Zúñiga-Ripa, A; Conde-Álvarez, R; Bagenda, F; Bonnet, M
Journal:
Scientific Reports
Abstract:
Human brucellosis, a chronic disease contracted through contact with animals and consuption of unpasteurized dairy products is underreported in limited-resource countries. This cross-sectional study aimed to determine the prevalence and risk factors of brucellosis among febrile patients attending a community hospital in South western Uganda. A questionnaire that captured socio-demographic, occupational and clinical data was administered. Blood samples were tested for Brucella antibodies using Rose Bengal Plate Test (RBPT) and blood culture with standard aerobic BACTEC bottle was done. Of 235 patients enrolled, prevalence of brucellosis (RBPT or culture confirmed) was 14.9% (95% CI 10.6-20.1) with a culture confrmation in 4.3% of the participants. The factors independently associated with brucellosis were consumption of raw milk (aOR 406.15, 95% CI 47.67-3461.69); history of brucellosis in the family (aOR 9.19, 95% CI 1.98-42.54); and selling hides and skins (aOR 162.56, 95% CI 2.86-9256.31). Hepatomegaly (p < 0.001), splenomegaly (p = 0.018) and low body mass index (p = 0.032) were more common in patients with brucellosis compared to others. Our findings reveal a high prevalence of brucellosis among febrile patients and highlight a need for implementing appropiate tests, public awareness activities and vaccination of animals to control and eliminate the disease.
Publisher:
Nature Research
Issue Date:
18-Oct-2018
URI:
http://hdl.handle.net/10144/619298
DOI:
10.1038/s41598-018-33915-9
PubMed ID:
30337685
Submitted date:
2018-11-01
Language:
en
ISSN:
2045-2322
Appears in Collections:
Other Diseases

Full metadata record

DC FieldValue Language
dc.contributor.authorMigisha, Ren
dc.contributor.authorDan Nen
dc.contributor.authorBoum, Yen
dc.contributor.authorPage, ALen
dc.contributor.authorZúñiga-Ripa, Aen
dc.contributor.authorConde-Álvarez, Ren
dc.contributor.authorBagenda, Fen
dc.contributor.authorBonnet, Men
dc.date.accessioned2018-11-01T18:43:08Z-
dc.date.available2018-11-01T18:43:08Z-
dc.date.issued2018-10-18-
dc.date.submitted2018-11-01-
dc.identifier.citationPrevalence and risk factors of brucellosis among febrile patients attending a community hospital in south western Uganda. 2018, 8 (1):15465 Sci Repen
dc.identifier.issn2045-2322-
dc.identifier.pmid30337685-
dc.identifier.doi10.1038/s41598-018-33915-9-
dc.identifier.urihttp://hdl.handle.net/10144/619298-
dc.description.abstractHuman brucellosis, a chronic disease contracted through contact with animals and consuption of unpasteurized dairy products is underreported in limited-resource countries. This cross-sectional study aimed to determine the prevalence and risk factors of brucellosis among febrile patients attending a community hospital in South western Uganda. A questionnaire that captured socio-demographic, occupational and clinical data was administered. Blood samples were tested for Brucella antibodies using Rose Bengal Plate Test (RBPT) and blood culture with standard aerobic BACTEC bottle was done. Of 235 patients enrolled, prevalence of brucellosis (RBPT or culture confirmed) was 14.9% (95% CI 10.6-20.1) with a culture confrmation in 4.3% of the participants. The factors independently associated with brucellosis were consumption of raw milk (aOR 406.15, 95% CI 47.67-3461.69); history of brucellosis in the family (aOR 9.19, 95% CI 1.98-42.54); and selling hides and skins (aOR 162.56, 95% CI 2.86-9256.31). Hepatomegaly (p < 0.001), splenomegaly (p = 0.018) and low body mass index (p = 0.032) were more common in patients with brucellosis compared to others. Our findings reveal a high prevalence of brucellosis among febrile patients and highlight a need for implementing appropiate tests, public awareness activities and vaccination of animals to control and eliminate the disease.en
dc.language.isoenen
dc.publisherNature Researchen
dc.rightsArchived with thanks to Scientific Reportsen
dc.titlePrevalence and risk factors of brucellosis among febrile patients attending a community hospital in south western Ugandaen
dc.identifier.journalScientific Reportsen
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