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Title: Outcomes of a remote, decentralized health center-based HIV/AIDS antiretroviral program in Zambia, 2003 to 2007
Authors: Elema, Riekje
Mills, Clair
Yun, Oliver
Lokuge, Kamalini
Ssonko, Charles
Nyirongo, Nashiola
Mtonga, Velepi
Zulu, Henry
Tu, David
Verputten, Meggy
O'Brien, Daniel P
Affiliation: Médecins Sans Frontières-Holland, Lusaka/Nchelenge, Zambia; Médecins Sans Frontières-Holland, Amsterdam, Netherlands; Médecins Sans Frontières-USA, New York; Ministry of Health, Lusaka/Nchelenge, Zambia; Médecins Sans Frontières-Holland, Vancouver, Canada
Citation: J Int Assoc Physicians AIDS Care (Chic Ill) 2009;8(1):60-7
Journal: Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)
Issue Date: 11-Feb-2009
DOI: 10.1177/1545109709331472
PubMed ID: 19211930
Additional Links:
Abstract: A cross-sectional study of patients living with HIV/ AIDS treated during 2003 to 2007 in decentralized, rural health centers in Zambia was performed to measure virological outcomes after 12 months of antiretroviral therapy and identify factors associated with virological failure. Data from 228 patients who started antiretroviral therapy >12 months prior were analyzed. In all, 93% received stavudine + lamivudine + nevirapine regimens, and median antiretroviral therapy duration was 23.5 months (interquartile range 20-28). Of the 205 patients tested for viral load, 177 (86%) had viral load <1000 copies/mL. Probability of developing virological failure (viral load >1000 copies/mL) was 8.9% at 24 months and 19.6% at 32 months. Predictors for virological failure were <100% adherence, body mass index <18.5 kg/m(2), and women <40 years old. Of those with virological failure who underwent 3 to 6 months of intensive adherence counseling, 45% obtained virological success. In a remote, resource-limited setting in decentralized health centers, virological and immunological assessments of patients on antiretroviral therapy >12 months showed that positive health outcomes are achievable.
Type: Article
Language: en
Keywords: antiretroviral therapy
rural health centers
sub-Saharan Africa
viral load
ISSN: 1545-1097
Rights: Archived with thanks to Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)
Appears in topics: HIV/AIDS

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