Development of dual-class antiretroviral drug resistance in a child coinfected with HIV and tuberculosis: a case report from KwaZulu-Natal, South Africa.

Hdl Handle:
http://hdl.handle.net/10144/71895
Title:
Development of dual-class antiretroviral drug resistance in a child coinfected with HIV and tuberculosis: a case report from KwaZulu-Natal, South Africa.
Authors:
Murphy, R A; France, H; Sunpath, H; Gordon, M L; Marconi, V; Kuritzkes, D R; McIntosh, K
Journal:
Journal of Tropical Pediatrics
Abstract:
The treatment of concurrent HIV and tuberculosis (TB) in children <3 years of age has not been well-studied and is complicated by potential drug-drug interactions. The recommended antiretroviral therapy (ART) in coinfected children in South Africa consists of full-strength ritonavir, lamivudine and stavudine. We report on a child initiated on this regimen, during concurrent TB treatment, who promptly developed an adverse reaction, virologic failure and dual-class antiretroviral drug resistance, compromising subsequent salvage ART.
Affiliation:
Massachusetts General Hospital, and Brigham and Women's Hospital, Boston, MA, USA. richard.murphy@newyork.msf.org
Publisher:
Published by Oxford University Press
Issue Date:
Feb-2009
URI:
http://hdl.handle.net/10144/71895
DOI:
10.1093/tropej/fmn074
PubMed ID:
18786985
Additional Links:
http://tropej.oxfordjournals.org/cgi/content/abstract/55/1/60
Language:
en
ISSN:
1465-3664
Appears in Collections:
HIV/AIDS

Full metadata record

DC FieldValue Language
dc.contributor.authorMurphy, R A-
dc.contributor.authorFrance, H-
dc.contributor.authorSunpath, H-
dc.contributor.authorGordon, M L-
dc.contributor.authorMarconi, V-
dc.contributor.authorKuritzkes, D R-
dc.contributor.authorMcIntosh, K-
dc.date.accessioned2009-06-30T09:28:37Z-
dc.date.available2009-06-30T09:28:37Z-
dc.date.issued2009-02-
dc.identifier.citationDevelopment of dual-class antiretroviral drug resistance in a child coinfected with HIV and tuberculosis: a case report from KwaZulu-Natal, South Africa. 2009, 55 (1):60-2 J. Trop. Pediatr.en
dc.identifier.issn1465-3664-
dc.identifier.pmid18786985-
dc.identifier.doi10.1093/tropej/fmn074-
dc.identifier.urihttp://hdl.handle.net/10144/71895-
dc.description.abstractThe treatment of concurrent HIV and tuberculosis (TB) in children <3 years of age has not been well-studied and is complicated by potential drug-drug interactions. The recommended antiretroviral therapy (ART) in coinfected children in South Africa consists of full-strength ritonavir, lamivudine and stavudine. We report on a child initiated on this regimen, during concurrent TB treatment, who promptly developed an adverse reaction, virologic failure and dual-class antiretroviral drug resistance, compromising subsequent salvage ART.en
dc.language.isoenen
dc.publisherPublished by Oxford University Pressen
dc.relation.urlhttp://tropej.oxfordjournals.org/cgi/content/abstract/55/1/60en
dc.rightsPublished by Oxford University Press Archived on this site with kind permission from Oxford University Pressen
dc.subject.meshAnti-HIV Agentsen
dc.subject.meshAntiretroviral Therapy, Highly Activeen
dc.subject.meshAntitubercular Agentsen
dc.subject.meshDrug Resistance, Viralen
dc.subject.meshDrug Therapy, Combinationen
dc.subject.meshHIV Infectionsen
dc.subject.meshHIV-1en
dc.subject.meshHumansen
dc.subject.meshInfanten
dc.subject.meshInfant, Newbornen
dc.subject.meshMaleen
dc.subject.meshRNA, Viralen
dc.subject.meshSouth Africaen
dc.subject.meshTreatment Outcomeen
dc.subject.meshTuberculosisen
dc.titleDevelopment of dual-class antiretroviral drug resistance in a child coinfected with HIV and tuberculosis: a case report from KwaZulu-Natal, South Africa.en
dc.contributor.departmentMassachusetts General Hospital, and Brigham and Women's Hospital, Boston, MA, USA. richard.murphy@newyork.msf.orgen
dc.identifier.journalJournal of Tropical Pediatricsen

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