Performance of FASTPlaqueTB and a modified protocol in a high HIV prevalence community in South Africa.

Hdl Handle:
http://hdl.handle.net/10144/75176
Title:
Performance of FASTPlaqueTB and a modified protocol in a high HIV prevalence community in South Africa.
Authors:
Trollip, A P; Albert, H; Mole, R; Marshall, T; van Cutsem, G; Coetzee, D
Journal:
The International Journal of Tuberculosis and Lung Disease : the official journal of the International Union against Tuberculosis and Lung Disease
Abstract:
Modifications in the FASTPlaqueTB test protocol have resulted in an increase in the analytical limits of detection. This study investigated whether the performance of a modified prototype was able to increase the detection of smear-negative, culture-positive sputum samples as compared to the first generation FASTPlaqueTB test. Modifications to the FASTPlaqueTB did result in increased detection of smear-negative samples, but this was associated with a decrease in the specificity of the test. Before the FASTPlaqueTB can be considered as a viable replacement for smear microscopy and culture for the identification of tuberculosis, further work is required to resolve the performance issues identified in this study.
Affiliation:
Biotec Laboratories South Africa Ltd, Cape Town, South Africa. andre.trollip@bioteclabs.co.za
Issue Date:
Jun-2009
URI:
http://hdl.handle.net/10144/75176
PubMed ID:
19460258
Language:
en
ISSN:
1027-3719
Appears in Collections:
TB; HIV/AIDS

Full metadata record

DC FieldValue Language
dc.contributor.authorTrollip, A P-
dc.contributor.authorAlbert, H-
dc.contributor.authorMole, R-
dc.contributor.authorMarshall, T-
dc.contributor.authorvan Cutsem, G-
dc.contributor.authorCoetzee, D-
dc.date.accessioned2009-07-23T10:31:21Z-
dc.date.available2009-07-23T10:31:21Z-
dc.date.issued2009-06-
dc.identifier.citationPerformance of FASTPlaqueTB and a modified protocol in a high HIV prevalence community in South Africa. 2009, 13 (6):791-3 Int. J. Tuberc. Lung Dis.en
dc.identifier.issn1027-3719-
dc.identifier.pmid19460258-
dc.identifier.urihttp://hdl.handle.net/10144/75176-
dc.description.abstractModifications in the FASTPlaqueTB test protocol have resulted in an increase in the analytical limits of detection. This study investigated whether the performance of a modified prototype was able to increase the detection of smear-negative, culture-positive sputum samples as compared to the first generation FASTPlaqueTB test. Modifications to the FASTPlaqueTB did result in increased detection of smear-negative samples, but this was associated with a decrease in the specificity of the test. Before the FASTPlaqueTB can be considered as a viable replacement for smear microscopy and culture for the identification of tuberculosis, further work is required to resolve the performance issues identified in this study.en
dc.language.isoenen
dc.rightsArchived with thanks to The International Journal of Tuberculosis and Lung Disease : the official journal of the International Union against Tuberculosis and Lung Diseaseen
dc.subject.meshComorbidityen
dc.subject.meshHIV Infectionsen
dc.subject.meshHumansen
dc.subject.meshMicrobial Sensitivity Testsen
dc.subject.meshPredictive Value of Testsen
dc.subject.meshSouth Africaen
dc.subject.meshSputumen
dc.subject.meshTuberculosis, Pulmonaryen
dc.titlePerformance of FASTPlaqueTB and a modified protocol in a high HIV prevalence community in South Africa.en
dc.contributor.departmentBiotec Laboratories South Africa Ltd, Cape Town, South Africa. andre.trollip@bioteclabs.co.zaen
dc.identifier.journalThe International Journal of Tuberculosis and Lung Disease : the official journal of the International Union against Tuberculosis and Lung Diseaseen

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