Prevalence study of yaws in the Democratic Republic of Congo using the lot quality assurance sampling method.

Hdl Handle:
http://hdl.handle.net/10144/77273
Title:
Prevalence study of yaws in the Democratic Republic of Congo using the lot quality assurance sampling method.
Authors:
Gerstl, S; Kiwila, G; Dhorda, M; Lonlas, S; Myatt, M; Ilunga, B K; Lemasson, D; Szumilin, E; Guerin, P J; Ferradini, L
Journal:
PloS One
Abstract:
BACKGROUND: Until the 1970s the prevalence of non-venereal trepanomatosis, including yaws, was greatly reduced after worldwide mass treatment. In 2005, cases were again reported in the Democratic Republic of the Congo. We carried out a survey to estimate the village-level prevalence of yaws in the region of Equator in the north of the country in order to define appropriate strategies to effectively treat the affected population. METHODOLOGY/PRINCIPAL FINDINGS: We designed a community-based survey using the Lot Quality Assurance Sampling method to classify the prevalence of active yaws in 14 groups of villages (lots). The classification into high, moderate, or low yaws prevalence corresponded to World Health Organization prevalence thresholds for identifying appropriate operational treatment strategies. Active yaws cases were defined by suggestive clinical signs and positive rapid plasma reagin and Treponema pallidum hemagglutination serological tests. The overall prevalence in the study area was 4.7% (95% confidence interval: 3.4-6.0). Two of 14 lots had high prevalence (>10%), three moderate prevalence (5-10%) and nine low prevalence (<5%.). CONCLUSIONS/SIGNIFICANCE: Although yaws is no longer a World Health Organization priority disease, the presence of yaws in a region where it was supposed to be eradicated demonstrates the importance of continued surveillance and control efforts. Yaws should remain a public health priority in countries where previously it was known to be endemic. The integration of sensitive surveillance systems together with free access to effective treatment is recommended. As a consequence of our study results, more than 16,000 people received free treatment against yaws.
Affiliation:
Epicentre, Paris, France. sgerstl@aol.com
Issue Date:
22-Jul-2009
URI:
http://hdl.handle.net/10144/77273
DOI:
10.1371/journal.pone.0006338
PubMed ID:
19623266
Language:
en
ISSN:
1932-6203
Appears in Collections:
Other Diseases

Full metadata record

DC FieldValue Language
dc.contributor.authorGerstl, S-
dc.contributor.authorKiwila, G-
dc.contributor.authorDhorda, M-
dc.contributor.authorLonlas, S-
dc.contributor.authorMyatt, M-
dc.contributor.authorIlunga, B K-
dc.contributor.authorLemasson, D-
dc.contributor.authorSzumilin, E-
dc.contributor.authorGuerin, P J-
dc.contributor.authorFerradini, L-
dc.date.accessioned2009-08-13T13:50:06Z-
dc.date.available2009-08-13T13:50:06Z-
dc.date.issued2009-07-22-
dc.identifier.citationPrevalence study of yaws in the Democratic Republic of Congo using the lot quality assurance sampling method. 2009, 4 (7):e6338 PLoS ONEen
dc.identifier.issn1932-6203-
dc.identifier.pmid19623266-
dc.identifier.doi10.1371/journal.pone.0006338-
dc.identifier.urihttp://hdl.handle.net/10144/77273-
dc.description.abstractBACKGROUND: Until the 1970s the prevalence of non-venereal trepanomatosis, including yaws, was greatly reduced after worldwide mass treatment. In 2005, cases were again reported in the Democratic Republic of the Congo. We carried out a survey to estimate the village-level prevalence of yaws in the region of Equator in the north of the country in order to define appropriate strategies to effectively treat the affected population. METHODOLOGY/PRINCIPAL FINDINGS: We designed a community-based survey using the Lot Quality Assurance Sampling method to classify the prevalence of active yaws in 14 groups of villages (lots). The classification into high, moderate, or low yaws prevalence corresponded to World Health Organization prevalence thresholds for identifying appropriate operational treatment strategies. Active yaws cases were defined by suggestive clinical signs and positive rapid plasma reagin and Treponema pallidum hemagglutination serological tests. The overall prevalence in the study area was 4.7% (95% confidence interval: 3.4-6.0). Two of 14 lots had high prevalence (>10%), three moderate prevalence (5-10%) and nine low prevalence (<5%.). CONCLUSIONS/SIGNIFICANCE: Although yaws is no longer a World Health Organization priority disease, the presence of yaws in a region where it was supposed to be eradicated demonstrates the importance of continued surveillance and control efforts. Yaws should remain a public health priority in countries where previously it was known to be endemic. The integration of sensitive surveillance systems together with free access to effective treatment is recommended. As a consequence of our study results, more than 16,000 people received free treatment against yaws.en
dc.language.isoenen
dc.rightsPublished by Public Library of Science, [url]http://www.plosone.org/[/url] Archived on this site by Open Access permissionen
dc.titlePrevalence study of yaws in the Democratic Republic of Congo using the lot quality assurance sampling method.en
dc.contributor.departmentEpicentre, Paris, France. sgerstl@aol.comen
dc.identifier.journalPloS Oneen

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