Natural history of a visceral leishmaniasis outbreak in highland Ethiopia

Hdl Handle:
http://hdl.handle.net/10144/83413
Title:
Natural history of a visceral leishmaniasis outbreak in highland Ethiopia
Authors:
Herrero, M; Orfanos, G; Argaw, D; Mulugeta, A; Aparicio, P; Parreño, F; Bernal, O; Rubens, D; Pedraza, J; Lima, M A; Flevaud, L; Palma, P P; Bashaye, S; Alvar, J; Bern, C
Journal:
American Journal of Tropical Medicine and Hygiene
Abstract:
In May 2005, visceral leishmaniasis (VL) was recognized for the first time in Libo Kemken, Ethiopia, a highland region where only few cases had been reported before. We analyzed records of VL patients treated from May 25, 2005 to December 13, 2007 by the only VL treatment center in the area, maintained by Médecins Sans Frontières-Ethiopia, Operational Center Barcelona-Athens. The median age was 18 years; 77.6% were male. The overall case fatality rate was 4%, but adults 45 years or older were five times as likely to die as 5-29 year olds. Other factors associated with increased mortality included HIV infection, edema, severe malnutrition, pneumonia, tuberculosis, and vomiting. The VL epidemic expanded rapidly over a several-year period, culminating in an epidemic peak in the last third of 2005, spread over two districts, and transformed into a sustained endemic situation by 2007.
Affiliation:
Disease Prevention and Control Programmes, World Health Organization, Addis Ababa, Ethiopia; Médecins Sans Frontières-Ethiopia, Operational Centre Barcelona-Athens, Addis Zemen, Ethiopia; Department for the Control of Neglected Tropical Diseases, Leishmaniasis Control Program, World Health Organization, Geneva, Switzerland; National Centre of Tropical Medicine, Instituto de Salud Carlos III, Madrid, Spain; Médecins Sans Frontières, Medical Department, Operational Centre Barcelona-Athens (OCBA), Barcelona, Spain; Malaria and Other Vector Borne Diseases, Prevention and Control Program, Ministry of Health, Addis Ababa, Ethiopia; Division of Parasitic Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia
Publisher:
American Society of Tropical Medicine and Hygiene
Issue Date:
1-Sep-2009
URI:
http://hdl.handle.net/10144/83413
PubMed ID:
19706898
Additional Links:
http://www.ajtmh.org/cgi/content/abstract/81/3/373
Submitted date:
2009-08-27
Type:
Article
Language:
en
ISSN:
1476-1645
Appears in Collections:
Leishmaniasis/Kala Azar

Full metadata record

DC FieldValue Language
dc.contributor.authorHerrero, M-
dc.contributor.authorOrfanos, G-
dc.contributor.authorArgaw, D-
dc.contributor.authorMulugeta, A-
dc.contributor.authorAparicio, P-
dc.contributor.authorParreño, F-
dc.contributor.authorBernal, O-
dc.contributor.authorRubens, D-
dc.contributor.authorPedraza, J-
dc.contributor.authorLima, M A-
dc.contributor.authorFlevaud, L-
dc.contributor.authorPalma, P P-
dc.contributor.authorBashaye, S-
dc.contributor.authorAlvar, J-
dc.contributor.authorBern, C-
dc.date.accessioned2009-10-04T14:27:06Z-
dc.date.available2009-10-04T14:27:06Z-
dc.date.issued2009-09-01-
dc.date.submitted2009-08-27-
dc.identifier.citationAm J Trop Med Hyg 2009;81(3):373-7en
dc.identifier.issn1476-1645-
dc.identifier.pmid19706898-
dc.identifier.urihttp://hdl.handle.net/10144/83413-
dc.description.abstractIn May 2005, visceral leishmaniasis (VL) was recognized for the first time in Libo Kemken, Ethiopia, a highland region where only few cases had been reported before. We analyzed records of VL patients treated from May 25, 2005 to December 13, 2007 by the only VL treatment center in the area, maintained by Médecins Sans Frontières-Ethiopia, Operational Center Barcelona-Athens. The median age was 18 years; 77.6% were male. The overall case fatality rate was 4%, but adults 45 years or older were five times as likely to die as 5-29 year olds. Other factors associated with increased mortality included HIV infection, edema, severe malnutrition, pneumonia, tuberculosis, and vomiting. The VL epidemic expanded rapidly over a several-year period, culminating in an epidemic peak in the last third of 2005, spread over two districts, and transformed into a sustained endemic situation by 2007.en
dc.language.isoenen
dc.publisherAmerican Society of Tropical Medicine and Hygieneen
dc.relation.urlhttp://www.ajtmh.org/cgi/content/abstract/81/3/373en
dc.rightsArchived with thanks to the American Journal of Tropical Medicine and Hygieneen
dc.subject.meshVisceral Leishmaniasisen
dc.subject.meshKala Azaren
dc.subject.meshDisease Outbreaken
dc.subject.meshEpidemicen
dc.subject.meshEthiopiaen
dc.titleNatural history of a visceral leishmaniasis outbreak in highland Ethiopiaen
dc.typeArticleen
dc.contributor.departmentDisease Prevention and Control Programmes, World Health Organization, Addis Ababa, Ethiopia; Médecins Sans Frontières-Ethiopia, Operational Centre Barcelona-Athens, Addis Zemen, Ethiopia; Department for the Control of Neglected Tropical Diseases, Leishmaniasis Control Program, World Health Organization, Geneva, Switzerland; National Centre of Tropical Medicine, Instituto de Salud Carlos III, Madrid, Spain; Médecins Sans Frontières, Medical Department, Operational Centre Barcelona-Athens (OCBA), Barcelona, Spain; Malaria and Other Vector Borne Diseases, Prevention and Control Program, Ministry of Health, Addis Ababa, Ethiopia; Division of Parasitic Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgiaen
dc.identifier.journalAmerican Journal of Tropical Medicine and Hygieneen

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