Factors Associated with Marburg Hemorrhagic Fever:

Hdl Handle:
http://hdl.handle.net/10144/99154
Title:
Factors Associated with Marburg Hemorrhagic Fever:
Authors:
Roddy, Paul; Sara L Thomas; Benjamin Jeffs; Pascoal Nascimento Folo; Pedro Pablo Palma; Bengi Moco Henrique; Luis Villa; Fernando Paixao Damiao Machado; Oscar Bernal; Steven M. Jones; James E. Strong; Heinz Feldmann; Matthias Borchert
Journal:
The Journal of Infectious Diseases
Abstract:
Background. Reliable on-site polymerase chain reaction (PCR) testing for Marburg hemorrhagic fever (MHF) is not always available. Therefore, clinicians triage patients on the basis of presenting symptoms and contact history. Using patient data collected in Uige, Angola, in 2005, we assessed the sensitivity and specificity of these factors to evaluate the validity of World Health Organization (WHO)–recommended case definitions for MHF. Methods. Multivariable logistic regression was used to identify independent predictors of PCR confirmation of MHF. A data-derived algorithm was developed to obtain new MHF case definitions with improved sensitivity and specificity. Results. A MHF case definition comprising (1) an epidemiological link or (2) the combination of myalgia or arthralgia and any hemorrhage could potentially serve as an alternative to current case definitions. Our dataderived case definitions maintained the sensitivity and improved the specificity of current WHO-recommended case definitions. Conclusions. Continued efforts to improve clinical documentation during filovirus outbreaks would aid in the refinement of case definitions and facilitate outbreak control.
Affiliation:
Medecins Sans Frontieres–Spain and others
Publisher:
Infectious Disease Society of America
Issue Date:
15-Jun-2010
URI:
http://hdl.handle.net/10144/99154
DOI:
10.1086/652748
Submitted date:
2009-06-15
Type:
Article
Language:
en
ISSN:
00221899; 15376613
Appears in Collections:
Other Diseases

Full metadata record

DC FieldValue Language
dc.contributor.authorRoddy, Paulen
dc.contributor.authorSara L Thomasen
dc.contributor.authorBenjamin Jeffsen
dc.contributor.authorPascoal Nascimento Foloen
dc.contributor.authorPedro Pablo Palmaen
dc.contributor.authorBengi Moco Henriqueen
dc.contributor.authorLuis Villaen
dc.contributor.authorFernando Paixao Damiao Machadoen
dc.contributor.authorOscar Bernalen
dc.contributor.authorSteven M. Jonesen
dc.contributor.authorJames E. Strongen
dc.contributor.authorHeinz Feldmannen
dc.contributor.authorMatthias Borcherten
dc.date.accessioned2010-05-18T15:26:34Z-
dc.date.available2010-05-18T15:26:34Z-
dc.date.issued2010-06-15-
dc.date.submitted2009-06-15-
dc.identifier.citationRoddy P, Thomas SL, Jeffs B, et al. Factors associated with Marburg hemorrhagic fever: analysis of patient data from Uige, Angola. Journal of Infectious Diseases. 2010;201(12)1909-1918en
dc.identifier.issn00221899-
dc.identifier.issn15376613-
dc.identifier.doi10.1086/652748-
dc.identifier.urihttp://hdl.handle.net/10144/99154-
dc.description.abstractBackground. Reliable on-site polymerase chain reaction (PCR) testing for Marburg hemorrhagic fever (MHF) is not always available. Therefore, clinicians triage patients on the basis of presenting symptoms and contact history. Using patient data collected in Uige, Angola, in 2005, we assessed the sensitivity and specificity of these factors to evaluate the validity of World Health Organization (WHO)–recommended case definitions for MHF. Methods. Multivariable logistic regression was used to identify independent predictors of PCR confirmation of MHF. A data-derived algorithm was developed to obtain new MHF case definitions with improved sensitivity and specificity. Results. A MHF case definition comprising (1) an epidemiological link or (2) the combination of myalgia or arthralgia and any hemorrhage could potentially serve as an alternative to current case definitions. Our dataderived case definitions maintained the sensitivity and improved the specificity of current WHO-recommended case definitions. Conclusions. Continued efforts to improve clinical documentation during filovirus outbreaks would aid in the refinement of case definitions and facilitate outbreak control.en
dc.language.isoenen
dc.publisherInfectious Disease Society of Americaen
dc.rightsPublished by Infectious Diseases Society of America Archived on this site with permission and copyright 2010 by the Infectious Diseases Society of America, [url]http://www.journals.uchicago.edu/toc/jid[/url]en
dc.subjectfilovirusen
dc.subjectcase definitionen
dc.titleFactors Associated with Marburg Hemorrhagic Fever:en
dc.typeArticleen
dc.contributor.departmentMedecins Sans Frontieres–Spain and othersen
dc.identifier.journalThe Journal of Infectious Diseasesen
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