Estimates of measles case fatality ratios: a comprehensive review of community-based studies.

Hdl Handle:
http://hdl.handle.net/10144/99349
Title:
Estimates of measles case fatality ratios: a comprehensive review of community-based studies.
Authors:
Wolfson, Lara J; Grais, Rebecca F; Luquero, Francisco J; Birmingham, Maureen E; Strebel, Peter M
Journal:
International Journal of Epidemiology
Abstract:
BACKGROUND: Global deaths from measles have decreased notably in past decades, due to both increases in immunization rates and decreases in measles case fatality ratios (CFRs). While some aspects of the reduction in measles mortality can be monitored through increases in immunization coverage, estimating the level of measles deaths (in absolute terms) is problematic, particularly since incidence-based methods of estimation rely on accurate measures of measles CFRs. These ratios vary widely by geographic and epidemiologic context and even within the same community from year-to-year. METHODS: To understand better the variations in CFRs, we reviewed community-based studies published between 1980 and 2008 reporting age-specific measles CFRs. RESULTS: The results of the search consistently document that measles CFRs are highest in unvaccinated children under age 5 years; in outbreaks; the lowest CFRs occur in vaccinated children regardless of setting. The broad range of case and death definitions, study populations and geography highlight the complexities in extrapolating results for global public health planning. CONCLUSIONS: Values for measles CFRs remain imprecise, resulting in continued uncertainty about the actual toll measles exacts.
Affiliation:
Health Security and Environment, World Health Organization, Geneva 27, Switzerland. wolfsonl@who.int
Issue Date:
Feb-2009
URI:
http://hdl.handle.net/10144/99349
DOI:
10.1093/ije/dyn224
PubMed ID:
19188207
Language:
en
ISSN:
1464-3685
Appears in Collections:
Other Diseases

Full metadata record

DC FieldValue Language
dc.contributor.authorWolfson, Lara Jen
dc.contributor.authorGrais, Rebecca Fen
dc.contributor.authorLuquero, Francisco Jen
dc.contributor.authorBirmingham, Maureen Een
dc.contributor.authorStrebel, Peter Men
dc.date.accessioned2010-05-19T18:43:41Z-
dc.date.available2010-05-19T18:43:41Z-
dc.date.issued2009-02-
dc.identifier.citationEstimates of measles case fatality ratios: a comprehensive review of community-based studies. 2009, 38 (1):192-205 Int J Epidemiolen
dc.identifier.issn1464-3685-
dc.identifier.pmid19188207-
dc.identifier.doi10.1093/ije/dyn224-
dc.identifier.urihttp://hdl.handle.net/10144/99349-
dc.description.abstractBACKGROUND: Global deaths from measles have decreased notably in past decades, due to both increases in immunization rates and decreases in measles case fatality ratios (CFRs). While some aspects of the reduction in measles mortality can be monitored through increases in immunization coverage, estimating the level of measles deaths (in absolute terms) is problematic, particularly since incidence-based methods of estimation rely on accurate measures of measles CFRs. These ratios vary widely by geographic and epidemiologic context and even within the same community from year-to-year. METHODS: To understand better the variations in CFRs, we reviewed community-based studies published between 1980 and 2008 reporting age-specific measles CFRs. RESULTS: The results of the search consistently document that measles CFRs are highest in unvaccinated children under age 5 years; in outbreaks; the lowest CFRs occur in vaccinated children regardless of setting. The broad range of case and death definitions, study populations and geography highlight the complexities in extrapolating results for global public health planning. CONCLUSIONS: Values for measles CFRs remain imprecise, resulting in continued uncertainty about the actual toll measles exacts.en
dc.language.isoenen
dc.rightsPublished by Oxford University Press Archived on this site with kind permission from Oxford University Press and the International Epidemiological Associationen
dc.subject.meshAge Factorsen
dc.subject.meshChilden
dc.subject.meshChild, Preschoolen
dc.subject.meshDeveloping Countriesen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshImmunizationen
dc.subject.meshInfanten
dc.subject.meshInfant, Newbornen
dc.subject.meshMaleen
dc.subject.meshMalnutritionen
dc.subject.meshMeaslesen
dc.subject.meshMeasles Vaccineen
dc.subject.meshRisk Factorsen
dc.subject.meshVitamin A Deficiencyen
dc.titleEstimates of measles case fatality ratios: a comprehensive review of community-based studies.en
dc.contributor.departmentHealth Security and Environment, World Health Organization, Geneva 27, Switzerland. wolfsonl@who.inten
dc.identifier.journalInternational Journal of Epidemiologyen

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